Polymerization‐Induced Helicity Inversion Driven by Stacking Modes and Self‐Assembly Pathway Differentiation

Small ◽  
2021 ◽  
pp. 2103177
Author(s):  
Xiaoxiao Cheng ◽  
Tengfei Miao ◽  
Haotian Ma ◽  
Jiandong Zhang ◽  
Zhengbiao Zhang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Assembly Pathway

Self-assembly pathway of nonsarcomeric myosin II

1991 ◽  
Vol 1991 (Supplement 14) ◽  
pp. 17-21 ◽  
Author(s):  
R. A. CROSS ◽  
T. P. HODGE ◽  
J. KENDRICK-JONES
Keyword(s):  
Self Assembly ◽  
Myosin Ii ◽  
Assembly Pathway

scholarly journals Revisiting the conformational state of albumin conjugated to gold nanoclusters: A self-assembly pathway to giant superstructures unraveled

PLoS ONE ◽  
2019 ◽  
Vol 14 (6) ◽  
pp. e0218975 ◽  
Author(s):  
Michał Kluz ◽  
Hanna Nieznańska ◽  
Robert Dec ◽  
Igor Dzięcielewski ◽  
Bartosz Niżyński ◽  
...  
Keyword(s):  
Self Assembly ◽  
Gold Nanoclusters ◽  
Conformational State ◽  
Assembly Pathway

The Effect of Solvent and Coordination Environment of Metal Source on the Self-Assembly Pathway of a Pd(II)-Mediated Coordination Capsule

2017 ◽  
Vol 56 (20) ◽  
pp. 12652-12663 ◽  
Author(s):  
Shumpei Kai ◽  
Yui Sakuma ◽  
Takako Mashiko ◽  
Tatsuo Kojima ◽  
Masanori Tachikawa ◽  
...  
Keyword(s):  
Self Assembly ◽  
The Self ◽  
Coordination Environment ◽  
Metal Source ◽  
Effect Of Solvent ◽  
Assembly Pathway

Identification of a major intermediate along the self-assembly pathway of an icosahedral viral capsid by using an analytical model of a spherical patch

Soft Matter ◽  
2016 ◽  
Vol 12 (32) ◽  
pp. 6728-6736 ◽  
Author(s):  
Didier Law-Hine ◽  
Mehdi Zeghal ◽  
Stéphane Bressanelli ◽  
Doru Constantin ◽  
Guillaume Tresset
Keyword(s):  
Analytical Model ◽  
Self Assembly ◽  
The Self ◽  
Viral Capsid ◽  
Assembly Pathway

Copillar[5]arene-based supramolecular polymer gel: controlling stimuli–response properties through a novel strategy with surfactant

RSC Advances ◽  
2015 ◽  
Vol 5 (74) ◽  
pp. 60273-60278 ◽  
Author(s):  
Taibao Wei ◽  
Hui Li ◽  
Yuanrong Zhu ◽  
Taotao Lu ◽  
Bingbing Shi ◽  
...  
Keyword(s):  
Self Assembly ◽  
Supramolecular Polymer ◽  
Polymer Gel ◽  
Response Properties ◽  
Assembly Pathway ◽  
Stimuli Response ◽  
Novel Strategy

Cartoon representation of self-assembly pathway of gelator DCP5-16 with G in CD3CN.

Genetic Exchange Leading to Self-Assembling RNA Species upon Encapsulation in Artificial Protocells

2007 ◽  
Vol 13 (3) ◽  
pp. 279-289 ◽  
Author(s):  
Sergio-Francis M. Zenisek ◽  
Eric J. Hayden ◽  
Niles Lehman
Keyword(s):  
Self Assembly ◽  
Divalent Cations ◽  
Direct Interaction ◽  
Living Systems ◽  
Oil Emulsion ◽  
Rna Molecules ◽  
Self Assembling ◽  
Assembly Pathway ◽  
Water In Oil Emulsion ◽  
Recombination Reactions

The encapsulation of information-bearing macromolecules inside protocells is a critical step in scenarios for the origins of life on the Earth as well as for the construction of artificial living systems. For these protocells to emulate life, they must be able to transmit genetic information to other cells. We have used a water-in-oil emulsion system to simulate the compartmentalization of catalytic RNA molecules. By exploiting RNA-directed recombination reactions previously developed in our laboratory, including a ribozyme self-assembly pathway, we demonstrate that it is possible for information to be exchanged among protocells. This can happen either indirectly by the passage of divalent cations through the inter-protocellular medium (oil), or by the direct interaction of two or more protocells that allows RNA molecules to be exchanged. The degree of agitation affects the ability of such exchange. The consequences of these results include the implications that prototypical living systems can transmit information among compartments, and that the environment can regulate the extent of this crosstalk.

scholarly journals A self-assembly pathway to aligned monodomain gels

2010 ◽  
Vol 9 (7) ◽  
pp. 594-601 ◽  
Author(s):  
Shuming Zhang ◽  
Megan A. Greenfield ◽  
Alvaro Mata ◽  
Liam C. Palmer ◽  
Ronit Bitton ◽  
...  
Keyword(s):  
Self Assembly ◽  
Assembly Pathway

scholarly journals Selectivity of Protein Interactions along the Aggregation Pathway of α-Synuclein

2021 ◽  
Author(s):  
André D. G. Leitão ◽  
Paulina Rudolffi Soto ◽  
Alexandre Chappard ◽  
Akshay Bhumkar ◽  
Dominic J. B. Hunter ◽  
...  
Keyword(s):  
Single Molecule ◽  
Protein Interactions ◽  
Self Assembly ◽  
Amyloid Fibrils ◽  
Lewy Bodies ◽  
Coincidence Detection ◽  
Protein Protein Interactions ◽  
Assembly Pathway ◽  
Protein Partners ◽  
Molecular Complexity

AbstractThe aggregation of α-SYN follows a cascade of oligomeric, prefibrillar and fibrillar forms, culminating in the formation of Lewy Bodies (LB), the pathological hallmarks of Parkinson’s Disease in neurons. Whilst α-synuclein is a major contributor to LB, these dense accumulations of protein aggregates and tangles of fibrils contain over 70 different proteins. However, the potential for interactions between these proteins and the different aggregated species of α-SYN is largely unknown. We hypothesized that the proteins present in the Lewy Bodies are trapped or pulled into the aggregates in a hierarchical manner, by binding at specific stages of the aggregation of α-SYN.In this study we uncover a map of interactions of a total of 65 proteins, against different species formed by α-SYN. We measured binding to monomeric α-SYN using AlphaScreen, a sensitive nano-bead assay for detection of protein-protein interactions. To access different oligomeric species, we made use of the pathological mutants of α-SYN (A30P, G51D and A53T), which form oligomeric species with distinct properties. Finally, we used bacterially expressed recombinant α-SYN to generate amyloid fibrils and measure interactions with a pool of GFP-tagged potential partners. Binding to oligomers and fibrils was measured by two-color coincidence detection (TCCD) on a single molecule spectroscopy setup. Overall, we demonstrate that LB components are selectively recruited to specific steps in the formation of the LB, explaining their presence in the inclusions. Only a few proteins were found to interact with α-SYN monomers at detectable levels, and only a subset recognizes the oligomeric α-SYN including autophagosomal proteins. We therefore propose a new model for the formation of Lewy Bodies, where selectivity of protein partners at different steps drives the arrangement of these structures, uncovering new ways to modulate aggregation.Significance StatementThe molecular complexity of the Lewy Bodies has been a major hindrance to a bottom-up reconstruction of these inclusions, protein by protein. This work presents an extensive dataset of protein-protein interactions, showing that despite its small size and absence of structure, α-SYN binds to specific partners in the LB, and that there is a clear selectivity of interactions between the different α-SYN species along the self-assembly pathway. We use single-molecule methods to deconvolute number and size of the co-aggregates, to gain detailed information about the mechanisms of interaction. These observations constitute the basis for the elaboration of a global interactome of α-SYN.

scholarly journals Porphyrin-based metal coordination polymers with self-assembly pathway-dependent properties for photodynamic and photothermal therapy

2020 ◽  
Author(s):  
Yuyang Miao ◽  
Shibo Lv ◽  
Daoyuan Zheng ◽  
Yuhan Liu ◽  
Dapeng Liu ◽  
...  
Keyword(s):  
Coordination Polymers ◽  
Self Assembly ◽  
Photothermal Therapy ◽  
The Self ◽  
Metal Coordination ◽  
Great Promise ◽  
Assembly Process ◽  
Assembly Pathway ◽  
Metal Organic ◽  
Metal Coordination Polymers

Abstract Porphyrin-based metal coordination polymers (MCPs) have attracted numerous attention due to their great promise application in phototherapy including photodynamic therapy (PDT) and photothermal therapy (PTT). However, the detailed self-assembly process of porphyrin-based MCPs still remains poorly understood. This work provides a detailed study of the self-assembly process of MCPs constructed by Mn2+ and TCPP (TCPP: 4,4′,4′′,4′′′-(Porphine-5,10,15,20-tetrayl)tetrakis(benzoic acid)) in aqueous solution. Unlike traditional nucleation and growth mechanism, we discover that there is a metastable metal-organic intermediate which is kinetically favored in the self-assembly process. And the metastable metal-organic intermediate nanotape structures could convert into thermodynamically favored nanosheets through disassembling into monomers followed by reassembling process. Moreover, the two structurally different assemblies exhibit distinct photophysical performances. The intermediate Mn-TCPP aggregates show good light-induced singlet oxygen 1O2 generation for PDT while the thermodynamic favored stable Mn-TCPP aggregates exhibit good photothermal conversion ability as photothermal agents (PTAs). This study could facilitate controlling self-assembly pathway to fabricate complex MCPs with desirable applications.

Sign in / Sign up

Export Citation Format

Share Document