scholarly journals OP04.02: First-trimester screening: do weight corrected free beta-HCG and PAPP-A values result in a significant higher detection rate of trisomy 21?

2010 ◽  
Vol 36 (S1) ◽  
pp. 61-62
Author(s):  
E. Merz ◽  
C. Thode ◽  
B. Eiben ◽  
S. Wellek
Keyword(s):  
Trisomy 21 ◽  
Detection Rate ◽  
First Trimester ◽  
First Trimester Screening ◽  
Beta Hcg ◽  
Trimester Screening

scholarly journals Performance of First-Trimester Screening between Gestational Weeks 7 and 13

2009 ◽  
Vol 55 (8) ◽  
pp. 1564-1567 ◽  
Author(s):  
Niels Tørring
Keyword(s):  
Blood Sample ◽  
Trisomy 21 ◽  
Detection Rate ◽  
First Trimester ◽  
Trisomy 13 ◽  
First Trimester Screening ◽  
Blood Samples ◽  
Before And After ◽  
Trimester Screening ◽  
Gestational Week

Abstract Background: Screening for fetal chromosome abnormalities in the first trimester includes analysis of the serological markers pregnancy-associated plasma protein A (PAPP-A) and free β human choriogonadotropin (free β hCG). The blood sample is traditionally taken around week 12 of gestation, but the performance of earlier blood sampling is not well documented. Methods: We studied 44 537 singleton pregnancies. Complete first-trimester screening took place between November 2003 and March 2009, and blood samples were taken between 7 weeks + 5 days and 13 weeks + 6 days. Results: Of 120 cases of trisomy 21, 108 were diagnosed in the first-trimester screening (detection rate 90%). When the blood sample was taken before gestational week 10, the detection rate of trisomy 21 was 97% (70 of 72), whereas 80% were detected (38 of 48) after week 10 (χ2 = 0.0035). For trisomy 18, trisomy 13, and triploidy, 65% (13 of 20) were detected before gestational week 10, and 73% (11 of 15) after (not significant). All 6 cases of triploidy before and after gestational week 10 were detected. The screen positive rate and the maternal age were similar before and after week 10 of gestation. Conclusions: Screening for fetal aneuploidy can be performed with good results with the blood sample taken as early as week 7 of gestation. Blood samples taken before gestational week 10 showed a high detection rate of fetal trisomy 21, with no difference in the detection of fetal trisomy 18, trisomy 13, or triploidy.

scholarly journals Two-stage first-trimester screening for trisomy 21 by ultrasound assessment and biochemical testing

2010 ◽  
Vol 36 (5) ◽  
pp. 542-547 ◽  
Author(s):  
K. O. Kagan ◽  
I. Staboulidou ◽  
J. Cruz ◽  
D. Wright ◽  
K. H. Nicolaides
Keyword(s):  
Trisomy 21 ◽  
First Trimester ◽  
First Trimester Screening ◽  
Two Stage ◽  
Trimester Screening ◽  
Ultrasound Assessment ◽  
Biochemical Testing

Sequential Pathways of Testing After First-Trimester Screening for Trisomy 21

2004 ◽  
Vol 104 (4) ◽  
pp. 661-666 ◽  
Author(s):  
Lawrence D. Platt ◽  
Naomi Greene ◽  
Anthony Johnson ◽  
Julia Zachary ◽  
Elizabeth Thom ◽  
...  
Keyword(s):  
Trisomy 21 ◽  
First Trimester ◽  
First Trimester Screening ◽  
Trimester Screening

Combined first trimester screening for trisomy 21: lack of agreement between risk calculation methods

2006 ◽  
Vol 34 (2) ◽  
Author(s):  
Peter N.A.C.M. Van Heesch ◽  
Peter C.J.I. Schielen ◽  
Mark F. Wildhagen ◽  
Karin den Hollander ◽  
Eric A.P. Steegers ◽  
...  
Keyword(s):  
Trisomy 21 ◽  
First Trimester ◽  
First Trimester Screening ◽  
Calculation Methods ◽  
Risk Calculation ◽  
Trimester Screening

First-Trimester Screening for Trisomy 21 Using Alpha-Fetoprotein

2011 ◽  
Vol 30 (3) ◽  
pp. 215-218 ◽  
Author(s):  
Foteini E. Bredaki ◽  
David Wright ◽  
Pedro Matos ◽  
Argyro Syngelaki ◽  
Kypros H. Nicolaides
Keyword(s):  
Trisomy 21 ◽  
First Trimester ◽  
Alpha Fetoprotein ◽  
First Trimester Screening ◽  
Trimester Screening

First-trimester screening for trisomy-21 using a simplified method to assess the presence or absence of the fetal nasal bone

2005 ◽  
Vol 192 (4) ◽  
pp. 1107-1111 ◽  
Author(s):  
Francesco Orlandi ◽  
Cinzia Rossi ◽  
Emanuela Orlandi ◽  
Maria Cristina Jakil ◽  
Terrence W. Hallahan ◽  
...  
Keyword(s):  
Trisomy 21 ◽  
Nasal Bone ◽  
First Trimester ◽  
First Trimester Screening ◽  
Fetal Nasal Bone ◽  
Simplified Method ◽  
Trimester Screening
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