Three-dimensional structure of the DNA-binding domain of the fructose repressor from Escherichia coli by 1H and 15N NMR

1997 ◽  
Vol 270 (3) ◽  
pp. 496-510 ◽  
Author(s):  
François Penin ◽  
Christophe Geourjon ◽  
Roland Montserret ◽  
Anja Böckmann ◽  
Anne Lesage ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Dna Binding ◽  
Three Dimensional ◽  
Binding Domain ◽  
Dimensional Structure ◽  
15N Nmr ◽  
Dna Binding Domain ◽  
Three Dimensional Structure

1H,15N Resonance Assignment and Three-dimensional Structure of CYP1 (HAP1) DNA-binding Domain

1996 ◽  
Vol 259 (4) ◽  
pp. 792-804 ◽  
Author(s):  
Johanna Timmerman ◽  
Anne-Lise Vuidepot ◽  
Francois Bontems ◽  
Jean-Yves Lallemand ◽  
Michel Gervais ◽  
...  
Keyword(s):  
Dna Binding ◽  
Resonance Assignment ◽  
Three Dimensional ◽  
Binding Domain ◽  
Dimensional Structure ◽  
Dna Binding Domain ◽  
Three Dimensional Structure

scholarly journals The Three-dimensional Structure of the C-terminal DNA-binding Domain of Human Ku70

2001 ◽  
Vol 276 (41) ◽  
pp. 38231-38236 ◽  
Author(s):  
Ziming Zhang ◽  
Lingyang Zhu ◽  
Donghai Lin ◽  
Fanqing Chen ◽  
David J. Chen ◽  
...  
Keyword(s):  
Dna Binding ◽  
Three Dimensional ◽  
Binding Domain ◽  
Dimensional Structure ◽  
Dna Binding Domain ◽  
Three Dimensional Structure

The lacI Gene as a Target for Mutation in Transgenic Rodents and Escherichia coli

Genetics ◽  
1998 ◽  
Vol 148 (4) ◽  
pp. 1441-1451
Author(s):  
Johan G de Boer ◽  
Barry W Glickman
Keyword(s):  
Escherichia Coli ◽  
Dna Repair ◽  
Dna Binding ◽  
Transgenic Animals ◽  
Single Copy ◽  
Binding Domain ◽  
Dna Binding Domain ◽  
Large Database ◽  
Deletion Mutations ◽  
Laci Gene

Abstract The lacI gene has been used extensively for the recovery and analysis of mutations in bacteria with various DNA repair backgrounds and after exposure to a wide variety of mutagens. This has resulted in a large database of information on mutational mechanisms and specificity of many mutagens, as well as the effect of DNA repair background on mutagenicity. Most importantly, knowledge about the mutational sensitivity of the lacI gene is now available, yielding information about mutable nucleotides. This popularity and available knowledge resulted in the use of the lacI gene in transgenic rodents for the study of mutagenesis in mammals, where it resides in ~40 repeated copies. As the number of sequenced mutations recovered from these animals increases, we are able to analyze the sites at which mutations have been recovered in great detail and to compare the recovered sites between bacteria and transgenic animals. The nucleotides that code for the DNA-binding domain are nearly saturated with base substitutions. Even after determining the sequences of ~10,000 mutations recovered from the animals, however, new sites and new changes are still being recovered. In addition, we compare the nature of deletion mutations between bacteria and animals. Based on the nature of deletions in the animals, we conclude that each deletion occurs in a single copy of the gene.

Sequence-specific1H n.m.r. assignments and determination of the three-dimensional structure of reduced escherichia coli glutaredoxin

1991 ◽  
Vol 221 (4) ◽  
pp. 1311-1324 ◽  
Author(s):  
Patrick Sodano ◽  
Tai-he Xia ◽  
John H. Bushweller ◽  
Olof Björnberg ◽  
Arne Holmgren ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Three Dimensional Structure

Three-Dimensional Structure of Escherichia coli Dihydrodipicolinate Reductase

Biochemistry ◽  
1995 ◽  
Vol 34 (11) ◽  
pp. 3502-3512 ◽  
Author(s):  
Giovanna Scapin ◽  
John S. Blanchard ◽  
James C. Sacchettini
Keyword(s):  
Escherichia Coli ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Three Dimensional Structure
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