Recurrent Basal Cell Carcinoma of the Lower Limb with Tibial Invasion

2006 ◽  
Vol 10 (1) ◽  
pp. 36-40
Author(s):  
Teresa Pérez de la Fuente ◽  
Isabel González González
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Lower Limb ◽  
Local Treatment ◽  
Muscle Flap ◽  
Lower Limbs ◽  
Tibial Osteotomy ◽  
Skin Malignancy ◽  
Local Bone

Background: Basal cell carcinoma (BCC) is the most common skin malignancy and is most prevalent on the head and neck region, although BCC can occur in other sites, including the lower limbs. Objective: We report the case of an 85-year-old female patient who experienced recurrent BCCs in the lower limb with tibial invasion. Methods: Treatment consisted of wide skin excision, tibial osteotomy, intraoperative cryotherapy, and coverage with an internal gastrocnemius muscle flap. Results: The computed tomographic scan showed local bone control of the BCC, with no recurrence, so we avoided limb amputation. Conclusion: The reported case is uncommon because of the site, the extent of bone infiltration, and local treatment with cryotherapy.

BOWENOID BASAL CELL CARCINOMA OF THE THUMB: A CASE REPORT AND REVIEW OF THE LITERATURE

Hand Surgery ◽  
2002 ◽  
Vol 07 (02) ◽  
pp. 295-298 ◽  
Author(s):  
M. Galeano ◽  
M. Colonna ◽  
M. Lentini ◽  
F. Stagno D'Alcontres
Keyword(s):  
Case Report ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Basal Layer ◽  
Rare Entity ◽  
Review Of The Literature ◽  
Skin Malignancy ◽  
Root Sheath ◽  
Common Skin

Basal cell carcinoma (BCC) is the most common skin malignancy arising from cells of the basal layer of the epithelium or from the external root sheath of the hair follicle. BCC of the digit is a rare entity. The article presents one such case of bowenoid BCC of the thumb which required amputation at the MP joint.

scholarly journals Basal Cell Carcinoma: From Pathophysiology to Novel Therapeutic Approaches

Biomedicines ◽  
2020 ◽  
Vol 8 (11) ◽  
pp. 449
Author(s):  
Luca Fania ◽  
Dario Didona ◽  
Roberto Morese ◽  
Irene Campana ◽  
Valeria Coco ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Hedgehog Signaling ◽  
Human Cancer ◽  
Local Treatment ◽  
Prevention Measures ◽  
Therapeutic Approaches ◽  
Genetic Characteristics ◽  
Novel Therapeutic

Basal cell carcinoma (BCC) is the most common human cancer worldwide, and is a subtype of nonmelanoma skin cancer, characterized by a constantly increasing incidence due to an aging population and widespread sun exposure. Although the mortality from BCC is negligible, this tumor can be associated with significant morbidity and cost. This review presents a literature overview of BCC from pathophysiology to novel therapeutic approaches. Several histopathological BCC subtypes with different prognostic values have been described. Dermoscopy and, more recently, reflectance confocal microscopy have largely improved BCC diagnosis. Although surgery is the first-line treatment for localized BCC, other nonsurgical local treatment options are available. BCC pathogenesis depends on the interaction between environmental and genetic characteristics of the patient. Specifically, an aberrant activation of Hedgehog signaling pathway is implicated in its pathogenesis. Notably, Hedgehog signaling inhibitors, such as vismodegib and sonidegib, are successfully used as targeted treatment for advanced or metastatic BCC. Furthermore, the implementation of prevention measures has demonstrated to be useful in the patient management.

Giant basal cell carcinoma of the face: surgical management and challenges for reconstruction

2015 ◽  
Vol 130 (2) ◽  
pp. 176-182 ◽  
Author(s):  
A Maimaiti ◽  
A Mijiti ◽  
A Yarbag ◽  
A Moming
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Basal Cell ◽  
Neck Region ◽  
Surgical Excision ◽  
Advancement Flap ◽  
Single Stage ◽  
Skin Malignancy ◽  
Giant Basal Cell Carcinoma

AbstractBackground:Giant basal cell carcinoma, in which the tumour measures 5 cm or greater in diameter, is a very rare skin malignancy that accounts for less than 1 per cent of all basal cell tumours. Very few studies have reported on the incidence, resection and reconstruction of this lesion worldwide.Methods:In total, 17 patients with giant basal cell carcinoma of the head and neck region underwent surgical excision and reconstruction at our hospital. Medical charts were retrospectively reviewed and analysed.Results:The lesion was usually in the forehead, eyelid, lips or nasal-cheek region. The greatest diameter ranged from 5 to 11 cm, with 5–6 cm being the most common size at the time of presentation. All patients had their tumour resected and reconstructed in a single-stage procedure, mostly with a local advancement flap, and with no post-operative flap failure.Conclusion:Giant basal cell carcinoma of the head and neck can be successfully treated with a local flap in a single-stage approach.

Rhabdomyosarcoma and rhabdomyoma associated with nevoid basal cell carcinoma syndrome: Local treatment strategy

2018 ◽  
Vol 35 (4) ◽  
pp. e245-e247 ◽  
Author(s):  
Adeline Kerbrat ◽  
Aurelie Beaufrere ◽  
Cecilia Neiva-Vaz ◽  
Louis Galmiche ◽  
Kahina Belhous ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Treatment Strategy ◽  
Local Treatment

Dermoscopic Features of Basal Cell Carcinoma on the Lower Limbs: A Chameleon!

Dermatology ◽  
2017 ◽  
Vol 233 (6) ◽  
pp. 482-488 ◽  
Author(s):  
Mara Lombardi ◽  
Riccardo Pampena ◽  
Stefania Borsari ◽  
Caterina Bombonato ◽  
Elisa Benati ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Lower Limbs

scholarly journals Advanced basal cell carcinomas of the face: A Moroccan series

2021 ◽  
Vol 12 (2) ◽  
pp. 135-139
Author(s):  
Sara Elloudi ◽  
Aida Oulehri ◽  
Hanane Baybay ◽  
Zakia Douhi ◽  
Fatima Zahra Mernissi
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Rural Areas ◽  
University Hospital ◽  
Temporal Region ◽  
Dermatology Department ◽  
Skin Malignancy ◽  
The Face ◽  
The University

Background: Basal cell carcinoma (BCC) is the most common cutaneous skin malignancy. 85% of BCCs affect the face, a region particularly rich in noble organs. Although BCC progresses slowly, considerable local destruction and mutilation may be observed. Material and Methods: We performed a retrospective review of the database stored by our institution. All patients with histologically confirmed mutilating basal cell carcinoma of the face hospitalized at the dermatology department of the university hospital in Fez, Morocco, from 2015 through 2020 were evaluated. Results: Nine patients were included, with the tumors located in the lips, temporal region, orbital region, and cheeks, with sizes varying from 5 to 11 cm. Conclusion: In the series, we were able to highlight the high-risk character of the subpopulation living in rural areas and the role of smoking as a major risk factor.

scholarly journals Modified Rhomboid Flap for Reconstruction of Defect of Cheek after Excision of Basal Cell Carcinoma

2016 ◽  
Vol 6 (2) ◽  
pp. 154-156
Author(s):  
Sunil Sidana ◽  
Adil Gandevivala ◽  
Dinesh H Shah ◽  
Akram Khan
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Laser Surgery ◽  
Human Face ◽  
Skin Malignancy ◽  
Basal Cell Carcinomas ◽  
Common Skin ◽  
Rhomboid Flap ◽  
Topical Medications

ABSTRACT The cheek is a very important part of the human face because it is the largest part and is essential in terms of both esthetics and functionality. Basal cell carcinomas (BCCs) are most common skin malignancy found in Caucasians and rarely in Asians. Treatment can range from topical medications, curettage, Mohs micrography, cryosurgery, laser surgery and excision. Defect left after excision can be cosmetically disfiguring. Options for reconstruction after excision of the lesion are skin graft and local flaps. We present a case of BCC of the cheek which was reconstructed with modified rhomboid flap. How to cite this article Gandevivala A, Shah DH, Sidana S, Khan A. Modified Rhomboid Flap for Reconstruction of Defect of Cheek after Excision of Basal Cell Carcinoma. J Contemp Dent 2016;6(2):154-156.

scholarly journals Screening mammogram microcalcification due to basal cell carcinoma of the skin

2012 ◽  
Vol 94 (2) ◽  
pp. e90-e91
Author(s):  
RS Cooper ◽  
E Eade ◽  
AP Nisbet ◽  
JT Allardice
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Breast Tissue ◽  
Screening Mammography ◽  
Screening Mammogram ◽  
Breast Malignancy ◽  
Skin Malignancy ◽  
Common Skin

Basal cell carcinoma is the most common skin malignancy worldwide, typically presenting as a pearly or translucent papule. Histologically, approximately 21% contain areas of microcalcification. We report a case of a woman presenting with microcalcification on screening mammography that was suspicious. Repeated core biopsies did not obtain microcalcification, and a diagnostic excision of breast tissue and overlying skin revealed an intradermal basal cell carcinoma containing the microcalcification. No breast malignancy was present. We believe this is the second such reported case in the literature and the first to be reported in Europe.

P1589Thiazides and skin cancer risk: should we be worried?

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
J P Sousa ◽  
L Puga ◽  
J Lopes ◽  
C Saleiro ◽  
C Lourenco ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Malignant Melanoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Thiazide Diuretic ◽  
Skin Malignancy ◽  
Carcinoma Squamous Cell

Abstract Introduction Diuretic thiazides represent a first-line therapeutic option for arterial hypertension. However, this drug class is regarded as having photosensitizing properties, and, as such, may act as a carcinogen, by triggering phototoxic reactions. Whether or not its long-term use increases skin malignancy risk remains unclear. Purpose To examine a possible association between thiazide usage and the risk of skin cancer, namely basal cell carcinoma, squamous cell carcinoma and malignant melanoma. Methods MEDLINE, EMBASE, Cochrane Library and Google Scholar databases were comprehensively searched, from inception to the first of February of 2019, for observational studies mentioning thiazide diuretic usage and incidence or prevalence of cutaneous basal cell carcinoma, squamous cell carcinoma and malignant melanoma. Literature review, study selection and appraisal, including methodological quality assessment, and data extraction were independently led by two investigators. Meta-analysis was conducted using generic inverse variance outcome and, due to heterogeneity of the original studies, a random effects model. Confounder-adjusted summary relative risk (RR), with 95% confidence interval (CI), was pooled. Results Ten studies met eligibility criteria. Of these, six had a case-control design and the remaining were cohort studies. Overall, 7,079,530 patients were included; 125,946 were diagnosed with basal cell carcinoma, 21,775 with squamous cell carcinoma and 31,191 with malignant melanoma. One study encompassed only squamous cell carcinoma of the lip. In five articles, individual thiazides employed were not addressed, whereas three embraced solely hydrochlorothiazide and other two exclusively bendroflumethiazide. Thiazides were found to be associated with increased risk of basal cell carcinoma (six studies, RR=1.05, 95% CI=1.01–1.10, p=0.02, i2=62%), squamous cell carcinoma (seven studies, RR=1.35, 95% CI=1.05–1.74, p=0.02, i2=92%) and malignant melanoma (six studies, RR=1.17, 95% CI 1.11–1.23, p<0.ehz748.03491, i2=0%). Conclusion Risk of all three major forms of skin malignancy is heightened in thiazide diuretic users. Increased awareness and education, especially for those who are at high risk and under the form of intense solar irradiation avoidance, are warranted for both patients and healthcare providers.

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