MyD88, Myeloid Differentiation Primary Response Gene 88

2012 ◽  
pp. 1149-1159
Author(s):  
Andreas Gewies ◽  
Jürgen Ruland ◽  
Alexey Kotlyarov ◽  
Matthias Gaestel ◽  
Shiri Procaccia ◽  
...  
Keyword(s):  
Primary Response ◽  
Myeloid Differentiation ◽  
Response Gene ◽  
Primary Response Gene

Myeloid differentiation primary response gene 88 (MyD88) deficiency in a large kindred

2010 ◽  
Vol 126 (1) ◽  
pp. 172-175 ◽  
Author(s):  
Daniel H. Conway ◽  
Jasmeen Dara ◽  
Asen Bagashev ◽  
Kathleen E. Sullivan
Keyword(s):  
Primary Response ◽  
Myeloid Differentiation ◽  
Response Gene ◽  
Primary Response Gene

scholarly journals Sequence of MyD116 cDNA: a novel myeloid differentiation primary response gene induced by IL6

1990 ◽  
Vol 18 (9) ◽  
pp. 2823-2823 ◽  
Author(s):  
Kenneth A. Lord ◽  
Barbara Hoffman-Liebermann ◽  
Dan A. Liebermann
Keyword(s):  
Primary Response ◽  
Myeloid Differentiation ◽  
Response Gene ◽  
Primary Response Gene

Dispensable role of myeloid differentiation primary response gene 88 (MyD88) and MyD88-dependent toll-like receptors (TLRs) in a murine model of osteoarthritis

2014 ◽  
Vol 81 (4) ◽  
pp. 320-324 ◽  
Author(s):  
Sonia Nasi ◽  
Hang-Korng Ea ◽  
Véronique Chobaz ◽  
Peter van Lent ◽  
Frédéric Lioté ◽  
...  
Keyword(s):  
Murine Model ◽  
Primary Response ◽  
Myeloid Differentiation ◽  
Toll Like Receptors ◽  
Response Gene ◽  
Primary Response Gene

scholarly journals Kaposi's Sarcoma-Associated Herpesvirus Reduces Cellular Myeloid Differentiation Primary-Response Gene 88 (MyD88) Expression via Modulation of Its RNA

2015 ◽  
Vol 90 (1) ◽  
pp. 180-188 ◽  
Author(s):  
Amy Lingel ◽  
Erica Ehlers ◽  
Qianli Wang ◽  
Mingxia Cao ◽  
Charles Wood ◽  
...  
Keyword(s):  
Kaposi's Sarcoma ◽  
Rna Synthesis ◽  
Kaposi’S Sarcoma ◽  
Primary Response ◽  
Lytic Replication ◽  
Myeloid Differentiation ◽  
Toll Like Receptor ◽  
Transcription Activator ◽  
Response Gene ◽  
Primary Response Gene

ABSTRACTKaposi's sarcoma (KS)-associated herpesvirus (KSHV) is a human gammaherpesvirus associated with several human malignancies. The replication and transcription activator (RTA) is necessary and sufficient for the switch from KSHV latency to lytic replication. Interleukin 1 (IL-1) is a major mediator for inflammation and plays an important role in both innate and adaptive immunity. Myeloid differentiation primary response gene 88 (MyD88) is an essential adaptor molecule for IL-1 as well as most Toll-like receptor signaling. In this study, we identified a novel mechanism by which KSHV interferes with host inflammation and immunity. KSHV RTA specifically reduces the steady-state protein levels of MyD88, and physiological levels of MyD88 are downregulated during KSHV lytic replication when RTA is expressed. The N-terminal region of RTA is required for the reduction of MyD88. Additional studies demonstrated that RTA targets MyD88 expression at the RNA level, inhibits RNA synthesis of MyD88, and may bind MyD88 RNA. Finally, RTA inhibits IL-1-mediated activation of NF-κB. Because IL-1 is abundant in the KS microenvironment and inhibits KSHV replication, this work may expand our understanding of how KSHV evades host inflammation and immunity for its survivalin vivo.IMPORTANCEMyD88 is an important molecule for IL-1-mediated inflammation and Toll-like receptor (TLR) signaling. This work shows that KSHV inhibits MyD88 expression through a novel mechanism. KSHV RTA may bind to MyD88 RNA, suppresses RNA synthesis of MyD88, and inhibits IL-1-mediated signaling. This work may expand our understanding of how KSHV evades host inflammation and immunity.

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