Isolation of an Adenosine Binding Protein Which Has Properties Expected of the A1 Adenosine Receptor

1990 ◽  
pp. 78-81
Author(s):  
K. Ravid ◽  
J. M. Lowenstein
Keyword(s):  
Adenosine Receptor ◽  
Binding Protein ◽  
A1 Adenosine Receptor ◽  
Adenosine Binding Protein

Pharmacology and Therapeutic Applications of A1 Adenosine Receptor Ligands

2003 ◽  
Vol 3 (4) ◽  
pp. 369-385 ◽  
Author(s):  
Arvinder Dhalla ◽  
John Shryock ◽  
Revati Shreeniwas ◽  
Luiz Belardinelli
Keyword(s):  
Adenosine Receptor ◽  
Receptor Ligands ◽  
A1 Adenosine Receptor ◽  
Therapeutic Applications ◽  
Adenosine Receptor Ligands

CPX, a selective A1-adenosine-receptor antagonist, regulates intracellular pH in cystic fibrosis cells

1995 ◽  
Vol 269 (1) ◽  
pp. C226-C233 ◽  
Author(s):  
V. Casavola ◽  
R. J. Turner ◽  
C. Guay-Broder ◽  
K. A. Jacobson ◽  
O. Eidelman ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Receptor Antagonist ◽  
Intracellular Ph ◽  
Adenosine Receptor ◽  
Ph Regulation ◽  
Cystic Fibrosis Transmembrane Regulator ◽  
Wild Type ◽  
A1 Adenosine Receptor ◽  
Adenosine Receptor Antagonist ◽  
Cystic Fibrosis Transmembrane

The selective A1-adenosine-receptor antagonist, 8-cyclopentyl-1,3-dipropylxanthine (CPX), has been reported to activate Cl- efflux from cystic fibrosis cells, such as pancreatic CFPAC-1 and lung IB3 cells bearing the cystic fibrosis transmembrane regulator(delta F508) mutation, but has little effect on the same process in cells repaired by transfection with wild-type cystic fibrosis transmembrane regulator (O. Eidelman, C. Guay-Broder, P. J. M. van Galen, K. A. Jacobson, C. Fox, R. J. Turner, Z. I. Cabantchik, and H. B. Pollard. Proc. Natl. Acad. Sci. USA 89: 5562-5566, 1992). We report here that CPX downregulates Na+/H+ exchange activity in CFPAC-1 cells but has a much smaller effect on cells repaired with the wild-type gene. CPX also mildly decreases resting intracellular pH. In CFPAC-1 cells, this downregulation is dependent on the presence of adenosine, since pretreatment of the cells with adenosine deaminase blocks the CPX effect. We also show that, by contrast, CPX action on these cells does not lead to alterations in intracellular free Ca2+ concentration. We conclude that CPX affects pH regulation in CFPAC-1 cells, probably by antagonizing the tonic action of endogenous adenosine.

Regulation of pharmacology by hetero-oligomerization between A1 adenosine receptor and P2Y2 receptor

2006 ◽  
Vol 351 (2) ◽  
pp. 559-565 ◽  
Author(s):  
Tokiko Suzuki ◽  
Kazunori Namba ◽  
Hirofumi Tsuga ◽  
Hiroyasu Nakata
Keyword(s):  
Adenosine Receptor ◽  
P2y2 Receptor ◽  
A1 Adenosine Receptor
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