Effect of Albumin or Serum on the Uptake and Degradation of Pyrene Cerebroside Sulfate by Lymphoblasts and Skin Fibroblasts

1988 ◽  
pp. 583-588
Author(s):  
P. Viani ◽  
S. Marchesini ◽  
S. Gatt
Keyword(s):  
Skin Fibroblasts ◽  
Cerebroside Sulfate

Electron Microscopy of Fibroblasts from Myotonic Muscular Dystrophy Patients

1981 ◽  
Vol 39 ◽  
pp. 498-499
Author(s):  
S. E. Miller ◽  
G. B. Hartwig ◽  
R. A. Nielsen ◽  
A. P. Frost ◽  
A. D. Roses
Keyword(s):  
Electron Microscopy ◽  
Muscular Dystrophy ◽  
Genetic Diseases ◽  
Skin Fibroblasts ◽  
Inborn Errors ◽  
Cytoplasmic Inclusions ◽  
Cultured Skin ◽  
Myotonic Muscular Dystrophy ◽  
Glycosaminoglycan Metabolism

Many genetic diseases can be demonstrated in skin cells cultured in vitro from patients with inborn errors of metabolism. Since myotonic muscular dystrophy (MMD) affects many organs other than muscle, it seems likely that this defect also might be expressed in fibroblasts. Detection of an alteration in cultured skin fibroblasts from patients would provide a valuable tool in the study of the disease as it would present a readily accessible and controllable system for examination. Furthermore, fibroblast expression would allow diagnosis of fetal and presumptomatic cases. An unusual staining pattern of MMD cultured skin fibroblasts as seen by light microscopy, namely, an increase in alcianophilia and metachromasia, has been reported; both these techniques suggest an altered glycosaminoglycan metabolism An altered growth pattern has also been described. One reference on cultured skin fibroblasts from a different dystrophy (Duchenne Muscular Dystrophy) reports increased cytoplasmic inclusions seen by electron microscopy. Also, ultrastructural alterations have been reported in muscle and thalamus biopsies from MMD patients, but no electron microscopical data is available on MMD cultured skin fibroblasts.

Benzyladenine and kinetin influence on skin fibroblasts proliferation and morphology

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
A Jabłońska-Trypuć ◽  
R Czerpak
Keyword(s):  
Skin Fibroblasts

Inhibition of androgen receptor binding by drugs in cultured human genital skin fibroblasts

1986 ◽  
Vol 113 (1_Suppl) ◽  
pp. S152
Author(s):  
M. BREINER ◽  
G. ROMALO ◽  
H.U. SCHWEIKERT
Keyword(s):  
Androgen Receptor ◽  
Receptor Binding ◽  
Skin Fibroblasts

117-LB: Nonviral Direct Reprogramming of Human Skin Fibroblasts into Hormone-Expressing ß-Like Cell Clusters

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 117-LB
Author(s):  
LUKE R. LEMMERMAN ◽  
MARIA ANGELICA RINCON-BENAVIDES ◽  
SARAH A. TERSEY ◽  
BRITANI N. BLACKSTONE ◽  
HEATHER M. POWELL ◽  
...  
Keyword(s):  
Human Skin ◽  
Skin Fibroblasts ◽  
Direct Reprogramming ◽  
Human Skin Fibroblasts ◽  
Cell Clusters
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