Background: Approximately 25% of patients with colorectal cancer present
synchronous metastases, most frequently located in the liver. Aims: The
assessment of optimal therapeutic strategies for the primary tumor in such
patients. Methods: We analyzed the outcomes of 209 patients who underwent
simultaneous or delayed resection of the primary tumor and liver metastases,
the survival rates of patients with initially unresectable liver metastases
that were rendered resectable, and the prognostic factors related to the
primary tumor. Results: The outcomes of simultaneous resections were similar
to those of delayed resection. In patients with initially unresectable liver
metastases that were rendered resectable, the survival rates were similar to
those of patients with initially resectable metastases. The survival rate of
N2 patients was significantly lower than those of N1 and N0 patients.
Conclusions: Simultaneous resection provides a safety profile and survival
rate similar to that of delayed resection. The N category allows for
prognostic estimation in metastatic colorectal patients.
Outcome and prognostic factors after resection of liver metastases in patients with colorectal cancer