Prosopis Cineraria Leaf Tannins: Their Inhibitory Effect Upon Ruminal Cellulase and the Recovery of Inhibition By Polyethylene Glycol — 4000

1992 ◽  
pp. 699-704 ◽  
Author(s):  
Ravindra Kumar
Keyword(s):  
Polyethylene Glycol ◽  
Inhibitory Effect ◽  
Polyethylene Glycol 4000 ◽  
Prosopis Cineraria

scholarly journals Artemisinin is highly soluble in polyethylene Glycol 4000 and such solution has multiple biological effects

2020 ◽  
Author(s):  
Fangyin Dai ◽  
Yu Bao ◽  
Zhi Li ◽  
Si-Hao Chen ◽  
Li-Zhi Gao ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Water Solubility ◽  
Biological Effects ◽  
Inflammatory Cells ◽  
Selective Inhibition ◽  
Inhibitory Effect ◽  
Human Hepatoma Cells ◽  
Polyethylene Glycol 4000 ◽  
Nitric Oxide Release ◽  
Anti Inflammatory

Artemisinin has a significant role in treatment of malaria, as well as effective anti-inflammatory and anti-cancer activities. However, such problems as poor water solubility and easy recrystallization limit its application. In this study, polyethylene glycol, a solvent which is widely used in pharmaceutics, was introduced to prepare an artemisinin dissolution. Under the action of hydrogen bonding in 12% polyethylene glycol 4000 solvent, the maximum solubility of artemisinin could reach up to 1 mg/mL. Meanwhile, biological functions of such artemisinin solution were evaluated. The obtained artemisinin solution had a significant inhibitory effect on Gram-positive bacteria, Gram-negative bacteria and fungi. As for the anti-inflammatory property, 0.031 mg/mL artemisinin solution had an obvious inhibitory effect on nitric oxide release in inflammatory cells, and the survival rate of cells was greater than 50%. Low concentration of the obtained artemisinin solution (0.031 mg/mL) had no significant cytotoxicity, while it displayed selective inhibition in cancer cells. IC50 for human hepatoma cells BEL-7404, SMMC7721 and Hep G2 is 0.0016 mg/mL, 0.0084 mg/mL and 0.0541 mg/mL, respectively. In conclusion, the 12% PEG4000-assisted artemisinin solution has a good biological effect and it can be further applied in pharmaceutics, biomaterials and medicine.

scholarly journals EFFECT OF SELECTED POLYMERS ON DISSOLUTION AND STABILIZATION OF AMORPHOUS FORM OF MELOXICAM

2017 ◽  
Vol 9 (9) ◽  
pp. 33
Author(s):  
Rana Obaidat ◽  
Bashar Al-taani ◽  
Hanan Al-quraan
Keyword(s):  
Polyethylene Glycol ◽  
Solid Dispersions ◽  
Dissolution Profile ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Polyethylene Glycol 4000 ◽  
Amorphous Form ◽  
Molecular Weights ◽  
Low Solubility ◽  
Reproducible Manner

Objective: Meloxicam is classified as class II corresponding to its high permeability and low solubility (12μg/ml). This study aims to compare the effect of selected polymers on stabilization of amorphous form, and dissolution of meloxicam by preparation of different solid dispersions using selected polymers (chitosan oligomers, polyvinylpyrrolidone K30, and polyethylene glycols).Methods: These solid dispersions were prepared using two different methods; solvent evaporation method for the two molecular weights chitosan carriers (16 and 11KDa) and polyvinylpyrrolidone-K30 and melting method for the two different molecular weights polyethylene glycol (4000 and 6000). The physicochemical properties of solid dispersions were analyzed using differential scanning calorimetry, Fourier transform infra-red analysis, Powder X-ray diffraction, and scanning electron microscopy. Selected dispersions were then compared to two selected marketed drugs (Mobic® and Moven®).Results: Best dissolution rates were obtained for both polyvinylpyrrolidone-K30 and polyethylene glycol 6000, followed by chitosan 16 kDa, chitosan 11 kDa, and polyethylene glycol 4000. Increasing polymeric ratio increased dissolution rate except for chitosan. Precipitation of the drug as amorphous form occurred in chitosan and polyvinylpyrrolidone-K30 dispersions, while no change in crystallinity obtained for polyethylene glycol dispersions. Failure of polyvinylpyrrolidone-K30 in the maintenance of stability during storage time was observed while re-crystallization occurred in chitosan-based dispersions, which ends with preferences to polyethylene glycol dispersions. After comparing the release of selected dispersions with the two selected polymers; all dispersions got a higher release than that of the two marketed drugs release.Conclusion: The dissolution profile of meloxicam has been increased successfully in a reproducible manner.

A Dose Determination Study of Polyethylene Glycol 4000 in Constipated Children: Factors Influencing the Maintenance Dose

2006 ◽  
Vol 42 (2) ◽  
pp. 178-185 ◽  
Author(s):  
Christophe Dupont ◽  
Bernard Leluyer ◽  
Fatme Amar ◽  
Nicolas Kalach ◽  
Pierre-Henri Benhamou ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Maintenance Dose ◽  
Polyethylene Glycol 4000 ◽  
Dose Determination ◽  
Factors Influencing

Efficacy of Two Regimens for Colon Cleansing Using Polyethylene Glycol 4000: A Randomized Open Label Trial

2021 ◽  
Vol 58 (12) ◽  
pp. 1119-1123
Author(s):  
Phan Thi Hien ◽  
Vu Huu Thoi ◽  
Nguyen Thu Ha ◽  
Nicolas Kalach
Keyword(s):  
Polyethylene Glycol ◽  
Open Label ◽  
Polyethylene Glycol 4000 ◽  
Colon Cleansing ◽  
Open Label Trial
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