Quantitation of P53 Tumor Suppressor Gene Copy Number in Tumor Dna Samples by Competitive PCR in an Elisa-Format

Author(s):  
Meinhard Hahn ◽  
Volker Dörsam ◽  
Alfred Pingoud
2021 ◽  
Vol 11 ◽  
Author(s):  
Xiaoxi Dong ◽  
Tiantian Zheng ◽  
Minhua Zhang ◽  
Chao Dai ◽  
Lili Wang ◽  
...  

Current liquid biopsy assays lack sufficient sensitivity to detect copy number loss, which limits the interrogation of critical tumor suppressor gene deletions during cancer progression and treatment. Here we describe a liquid biopsy assay with improved sensitivity for detection of copy number loss in blood samples with low levels of circulating tumor DNA, and demonstrate its utility by profiling PTEN, RB1, and TP53 genetic loss in metastatic prostate cancer patients.


1993 ◽  
Vol 169 (3) ◽  
pp. 690-694 ◽  
Author(s):  
Matthew F. Kohler ◽  
Hiroshi Nishii ◽  
Peter A. Humphrey ◽  
Hiroshi Saski ◽  
Jeffrey Marks ◽  
...  

Cancer ◽  
2000 ◽  
Vol 88 (7) ◽  
pp. 1565-1573 ◽  
Author(s):  
Sanjay Katiyar ◽  
Bipin C. Dash ◽  
Varsha Thakur ◽  
Raj C. Guptan ◽  
Shiv K. Sarin ◽  
...  

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