Investigations on the Functional Role of Angiotensin Converting Enzyme (ACE) in Human Seminal Plasma

1986 ◽  
pp. 477-485 ◽  
Author(s):  
Franz Krassnigg ◽  
Harald Niederhauser ◽  
Rainer Placzek ◽  
Julian Frick ◽  
Wolf-Bernhard Schill
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Seminal Plasma ◽  
Functional Role ◽  
Converting Enzyme ◽  
Human Seminal Plasma

Urinary ACE2 in healthy adults and patients with uncomplicated type 1 diabetes

2014 ◽  
Vol 92 (8) ◽  
pp. 703-706 ◽  
Author(s):  
David Z.I. Cherney ◽  
Fengxia Xiao ◽  
Joseph Zimpelmann ◽  
Ronnie L.H. Har ◽  
Vesta Lai ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Enzyme Activity ◽  
Angiotensin Converting Enzyme ◽  
Functional Role ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme 2 ◽  
Protein Levels ◽  
Clinical Complications

Angiotensin-converting enzyme 2 (ACE2) is expressed in the kidney and may be renoprotective. We determined whether urinary ACE2 enzyme activity and protein levels (ELISA), as well as angiotensinogen and ACE, are elevated during clamped euglycemia (4–6 mmol·L–1) in patients with uncomplicated type 1 diabetes (T1D, n = 58) compared with normoglycemic controls (n = 21). We also measured the effect of clamped hyperglycemia (9–11 mmol·L–1) on each urinary factor in T1D patients. Urinary ACE2 activity and protein levels were higher during clamped euglycemia in T1D compared with the controls (p < 0.0001). In contrast, urinary angiotensinogen levels (p = 0.27) and ACE excretion (p = 0.68) did not differ. In response to clamped hyperglycemia in T1D, urinary ACE2 protein decreased (p < 0.0001), whereas urinary ACE2 activity as well as angiotensinogen and ACE levels remained unchanged. Urinary ACE2 activity and protein expression are increased in T1D patients prior to the onset of clinical complications. Further work is required to determine the functional role of urinary ACE2 in early T1D.

Study of Peptides Inhibiting the Angiotensin-Converting Enzyme of Human Seminal Plasma

Enzyme ◽  
1979 ◽  
Vol 24 (6) ◽  
pp. 362-365 ◽  
Author(s):  
D. Depierre ◽  
J.-P. Bargetzi ◽  
M. Roth
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Seminal Plasma ◽  
Converting Enzyme ◽  
Human Seminal Plasma
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