Long-Term Effects of AF64A on Learning and Memory Processes in the Rat

1986 ◽  
pp. 1127-1136
Author(s):  
T. J. Walsh ◽  
D. L. DeHaven ◽  
A. Russell ◽  
I. Hanin
Keyword(s):  
Learning And Memory ◽  
Long Term Effects ◽  
Memory Processes

Long-term effects of selective neonatal temporal lobe lesions on learning and memory in monkeys.

1995 ◽  
Vol 109 (2) ◽  
pp. 212-226 ◽  
Author(s):  
Ludiše Málková ◽  
Mortimer Mishkin ◽  
Jocelyne Bachevalier
Keyword(s):  
Learning And Memory ◽  
Temporal Lobe ◽  
Long Term Effects ◽  
Temporal Lobe Lesions

scholarly journals Multiple Kainic Acid Seizures in the Immature and Adult Brain: Ictal Manifestations and Long-Term Effects on Learning and Memory

Epilepsia ◽  
1997 ◽  
Vol 38 (11) ◽  
pp. 1157-1166 ◽  
Author(s):  
Matthew R. Sarkisian ◽  
Pushpa Tandon ◽  
Zhao Liu ◽  
Yili Yang ◽  
Ariyuki Hori ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Kainic Acid ◽  
Adult Brain ◽  
Long Term Effects

Effects of long-term voluntary exercise on learning and memory processes: dependency of the task and level of exercise

2009 ◽  
Vol 202 (2) ◽  
pp. 162-170 ◽  
Author(s):  
Sílvia García-Capdevila ◽  
Isabel Portell-Cortés ◽  
Meritxell Torras-Garcia ◽  
Margalida Coll-Andreu ◽  
David Costa-Miserachs
Keyword(s):  
Learning And Memory ◽  
Voluntary Exercise ◽  
Memory Processes

scholarly journals Learning and Memory Effects of Neonatal Methamphetamine Exposure in Sprague-Dawley Rats: Test of the Role of Dopamine Receptors D1 in Mediating the Long-Term Effects

2019 ◽  
Vol 41 (1-2) ◽  
pp. 44-55 ◽  
Author(s):  
Sarah A. Jablonski ◽  
Michael T. Williams ◽  
Charles V. Vorhees
Keyword(s):  
Learning And Memory ◽  
Water Maze ◽  
High Dose ◽  
Sprague Dawley ◽  
Long Term Effects ◽  
Learning Deficits ◽  
Sprague Dawley Rats ◽  
Cincinnati Water Maze ◽  
Locomotor Deficits

Methamphetamine (MA) abuse is a worldwide issue that produces health and cognitive effects in the user. MA is abused by some women who then become pregnant and expose their developing child to the drug. Preclinical rodent models demonstrate cognitive deficits following developmental MA exposure, an effect observed in children exposed to MA in utero. To determine if the dopamine receptor D1 (DRD1) is involved in the learning and memory deficits following MA exposure, male Sprague-Dawley rats were treated 4 times daily at 2 h intervals with 0 (saline) or 10 mg/kg of MA from postnatal day (P)6–15, 30 min after 0.5, 1.0, or 2.0 mg/kg SCH23390. Cincinnati water maze testing began on P30, and the high dose of SCH23390 blocked the learning deficits induced by MA with no effect from the lower doses. Morris water maze (MWM) learning deficits following MA were not protected by SCH23390, although there was a non-dose dependent effect in the acquisition phase. Locomotor deficits induced by MA were reversed by all doses of SCH23390. There were no effects of MA on criterion to trial passive avoidance. Taken together, these data show that behaviors that are dependent on the striatum are better protected with the DRD1 antagonist during MA treatment than the hippocampally mediated spatial learning in the MWM. This suggests that multiple mechanisms exist for the deficits induced by neonatal MA administration.

scholarly journals Prenatal Caffeine Damaged Learning and Memory in Rat Offspring Mediated by ARs/PKA/CREB/BDNF Pathway

2018 ◽  
pp. 975-983 ◽  
Author(s):  
Y. LI ◽  
W. ZHANG ◽  
R. SHI ◽  
M. SUN ◽  
L. ZHANG ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Maze Learning ◽  
Adult Offspring ◽  
Sprague Dawley ◽  
Long Term Effects ◽  
Developmental Problems ◽  
A2a Receptors ◽  
Rat Offspring ◽  
Sprague Dawley Rats

Prenatal exposure to caffeine can cause developmental problems. This study determined chronic influence of prenatal caffeine at relatively higher doses on cognitive functions in the rat offspring. Pregnant Sprague-Dawley rats (4-month-old) were exposed to caffeine (20 mg/kg, twice a day) for whole pregnancy from gestational day 4. Fetal and offspring body and brain weight was measured. Learning and memory were tested in adult offspring with Morris water maze. Learning and memory-related receptors were measured. The exposure to prenatal caffeine not only caused fetal growth restriction, but also showed long-term effects on learning and memory in the offspring. The caffeine offspring exhibited longer escape latency and path length in navigation testing. The number of passing the target was significantly reduced in those offspring. The expression of adenosine A1 and A2A receptors, nuclear PKA Cα, Cβ subunits, and pCREB were significantly increased in the fetal and neonatal brain, and suppressed in the hippocampus of the adult offspring. The expression of BDNF and TrkB were reduced regardless of various ages. The results suggest that intrauterine programming dysfunction of adenosine receptors and the down-stream of cAMP/PKA/pCREB system may play an important role in prenatal caffeine induced cognition disorders in the adult offspring.

Neural long-term effects of emotion regulation on episodic memory processes

2010 ◽  
Vol 48 (4) ◽  
pp. 989-996 ◽  
Author(s):  
Susanne Erk ◽  
Alexander von Kalckreuth ◽  
Henrik Walter
Keyword(s):  
Emotion Regulation ◽  
Episodic Memory ◽  
Long Term Effects ◽  
Memory Processes

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

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