<b>Objective: </b>Type 1 (T1D) and type 2
diabetes (T2D) increase risks of cardiovascular and renal disease (CVRD)
compared to diabetes-free populations. Direct comparisons between T1D and T2D
are scarce. We examined this by pooling full-population cohorts in Sweden and
Norway.
<p><b>Research Design and Methods: </b>59,331
T1D and 484,241 T2D patients, aged 18-84 years, were followed over a mean period
of 2.6 years from December 31, 2013. Patients were identified in nationwide prescribed
drug and hospital registries in Norway and Sweden<b>. </b>Prevalence and event rates
of myocardial infarction (MI), heart failure (HF), stroke, chronic kidney
disease (CKD), all-cause death and cardiovascular death were assessed following
age stratification in 5-year intervals. Cox regression analyses were used to estimate
risk.</p>
<p><b>Results: </b>The prevalence of cardiovascular
disease was similar in T1D and T2D across age strata, whereas CKD was more
common in T1D. Age-adjusted event-rates comparing T1D versus T2D showed that HF
risk was increased between the ages 65-79 years, MI between 55-79 years and
stroke between 40-54 years, 1.3-1.4-fold, 1.3-1.8-fold and 1.4-1.7 fold respectively.
CKD risk was 1.4-3.0-fold higher in T1D at all ages. The all-cause death risk was
1.2-1.5-fold higher in T1D above 50 years, with a similar trend for CV death.</p>
<p><b>Conclusions: </b>Adult T1D compared to T2D patients
had an overall greater risk of cardiorenal disease (heart failure and CKD) across ages, of MI and
all-cause death at middle-older ages and of stroke at younger ages. The total age-adjusted
CVRD burden and risks were greater among T1D patients compared to T2D, highlighting
their need for improved prevention strategies.</p>
A Differential Diagnosis Model For Diabetic Nephropathy And Non-Diabetic Renal Disease In Patients With Type 2 Diabetes Complicated With Chronic Kidney Disease