Future Perspectives and Clinical Applications

2019 ◽  
pp. 153-160
Author(s):  
Claudio Maurizio Pacella ◽  
Giovanni Mauri ◽  
Luca Breschi ◽  
Tian’an Jiang
Keyword(s):  
Clinical Applications ◽  
Future Perspectives

Recent Advances in Computational Methods for Identifying Anticancer Peptides

2019 ◽  
Vol 20 (5) ◽  
pp. 481-487 ◽  
Author(s):  
Pengmian Feng ◽  
Zhenyi Wang
Keyword(s):  
Computational Methods ◽  
Clinical Applications ◽  
Future Perspectives ◽  
Small Peptides ◽  
Accurate Identification ◽  
Normal Cells ◽  
Anticancer Peptide ◽  
Anticancer Peptides ◽  
Computational Identification ◽  
Reliable Methods

Anticancer peptide (ACP) is a kind of small peptides that can kill cancer cells without damaging normal cells. In recent years, ACP has been pre-clinically used for cancer treatment. Therefore, accurate identification of ACPs will promote their clinical applications. In contrast to labor-intensive experimental techniques, a series of computational methods have been proposed for identifying ACPs. In this review, we briefly summarized the current progress in computational identification of ACPs. The challenges and future perspectives in developing reliable methods for identification of ACPs were also discussed. We anticipate that this review could provide novel insights into future researches on anticancer peptides.

scholarly journals Current Perspectives Regarding Stem Cell-Based Therapy for Liver Cirrhosis

2018 ◽  
Vol 2018 ◽  
pp. 1-19 ◽  
Author(s):  
Kyeong-Ah Kwak ◽  
Hyun-Jae Cho ◽  
Jin-Young Yang ◽  
Young-Seok Park
Keyword(s):  
Liver Cirrhosis ◽  
Stem Cell ◽  
Mechanisms Of Action ◽  
Clinical Applications ◽  
Hepatic Regeneration ◽  
Future Perspectives ◽  
Cell Type ◽  
Cell Based Therapy ◽  
Preclinical And Clinical Studies ◽  
Different Origins

Liver cirrhosis is a major cause of mortality and a common end of various progressive liver diseases. Since the effective treatment is currently limited to liver transplantation, stem cell-based therapy as an alternative has attracted interest due to promising results from preclinical and clinical studies. However, there is still much to be understood regarding the precise mechanisms of action. A number of stem cells from different origins have been employed for hepatic regeneration with different degrees of success. The present review presents a synopsis of stem cell research for the treatment of patients with liver cirrhosis according to the stem cell type. Clinical trials to date are summarized briefly. Finally, issues to be resolved and future perspectives are discussed with regard to clinical applications.

scholarly journals Infantile Brain Tumors: A Review of Literature and Future Perspectives

Diagnostics ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 670
Author(s):  
Valeria Simone ◽  
Daniela Rizzo ◽  
Alessandro Cocciolo ◽  
Anna Maria Caroleo ◽  
Andrea Carai ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Therapeutic Strategies ◽  
Clinical Applications ◽  
Review Of Literature ◽  
Future Perspectives ◽  
Older Children ◽  
Nervous System Tumors ◽  
Molecular Landscape ◽  
Specific Symptoms

Brain tumors in infants including those diagnosed in fetal age, newborns and under a year old represent less than 10% of pediatric nervous system tumors and present differently when compared with older children in terms of clinical traits, location and histology. The most frequent clinical finding is a macrocephaly but non-specific symptoms can also be associated. The prognosis is usually poor and depends on several factors. Surgery continues to be the main option in terms of therapeutic strategies whereas the role of chemotherapy is not yet well defined and radiotherapy is exceptionally undertaken. In view of this situation, a molecular characterization could assist in providing therapeutic options for these tumors. This review highlights the recent advances in the diagnosis and treatment of brain tumors in infants with a particular focus on the molecular landscape and future clinical applications.

A Review of Light Sources and Enhanced Targeting for Photodynamic Therapy.

2021 ◽  
Vol 28 ◽  
Author(s):  
Menghua Xiang ◽  
Quanming Zhou ◽  
Zihan Shi ◽  
Xuan Wang ◽  
Mengchu Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Applications ◽  
Light Sources ◽  
Oxygen Species ◽  
Future Perspectives ◽  
Local Irradiation ◽  
Advantages And Disadvantages ◽  
The Past ◽  
In Situ Generation

: Photodynamic Therapy (PDT), as a clinically approved modality for the treatment of various disordered diseases including cancer, has received great advances in recent years. By preferentially accumulating non-toxic Photosensitizers (PSs) in the pathological area, and in situ generation of cytotoxic reactive oxygen species (ROS) under local irradiation by a light source with appropriate wavelength, PDT works in a dual-selective manner. Over the past decades, numerous studies and reviews on PDT mainly focused on activable PSs and the newly emerging PSs in PDT. However, to the best of our knowledge, there are few articles on the systematic introduction of light sources and limited reports about targeted strategies in PDT. This review comprehensively summarizes various light sources applied in PDT together with typical enhanced targeting strategies, and outlines their advantages and disadvantages, respectively. The clinical applications and future perspectives in light sources are also partly presented and discussed.

scholarly journals Regenerative medicine: Clinical applications and future perspectives

2017 ◽  
Vol 5 (1) ◽  
pp. 1 ◽  
Author(s):  
Antonello Forgione ◽  
Federica Colombo ◽  
Gianluca Sampogna ◽  
Giovanni Cocozza ◽  
SalmanYousuf Guraya
Keyword(s):  
Regenerative Medicine ◽  
Clinical Applications ◽  
Future Perspectives
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