Oral Tolerance and Prognosis in Food Allergy

2020 ◽  
pp. 213-223
Author(s):  
David R. Stukus
Keyword(s):  
Food Allergy ◽  
Oral Tolerance

scholarly journals Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways

Cell Reports ◽  
2016 ◽  
Vol 15 (12) ◽  
pp. 2809-2824 ◽  
Author(s):  
Jian Tan ◽  
Craig McKenzie ◽  
Peter J. Vuillermin ◽  
Gera Goverse ◽  
Carola G. Vinuesa ◽  
...  
Keyword(s):  
Food Allergy ◽  
Dietary Fiber ◽  
Oral Tolerance ◽  
Cellular Pathways

scholarly journals Oral Tolerance Induced by Transfer of Food Antigens via Breast Milk of Allergic Mothers Prevents Offspring from Developing Allergic Symptoms in a Mouse Food Allergy Model

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Takeshi Yamamoto ◽  
Yuma Tsubota ◽  
Toshihisa Kodama ◽  
Natsuko Kageyama-Yahara ◽  
Makoto Kadowaki
Keyword(s):  
Food Allergy ◽  
Breast Milk ◽  
Oral Tolerance ◽  
Maternal Exposure ◽  
Oral Intubation ◽  
Female Mice ◽  
Allergic Symptoms ◽  
Dietary Antigens ◽  
Food Antigens

We examined whether maternal exposure to food antigens during lactation and maternal allergic status would affect the development of food allergy in offspring. OVA-sensitized or OVA-nonsensitized BALB/c female mice were exposed or unexposed to OVA during lactation. After weaning, their offspring were systemically sensitized twice with OVA and repeatedly given OVA by oral intubation. While 97.1% of the mice breastfed by OVA-nonsensitized and OVA-unexposed mothers developed allergic diarrhea, 59.7% of the mice breastfed by OVA-exposed nonallergic mothers during lactation and 24.6% of the mice breastfed by OVA-exposed allergic mothers during lactation developed food allergy. Furthermore, OVA was detected in breast-milk from OVA-exposed nonallergic mothers during lactation (4.6±0.5 μg/mL). In addition, OVA-specific IgG1 titers were markedly increased in breast milk from allergic mothers (OVA-sensitized and OVA-unexposed mother:11.0±0.5, OVA-sensitized and OVA-exposed mother:12.3±0.3). Our results suggest that oral tolerance induced by breast milk-mediated transfer of dietary antigens along with their specific immunoglobulins to offspring leads to antigen-specific protection from food allergy.

Food allergy: oral tolerance or immunotherapy?

2007 ◽  
Vol 35 (5) ◽  
pp. 165-168 ◽  
Author(s):  
F. Muñoz-López
Keyword(s):  
Food Allergy ◽  
Oral Tolerance

scholarly journals Tight joints and zonulin in the formation of oral tolerance and food allergy

2019 ◽  
pp. 5-9
Author(s):  
N. G. Prikhodchenko ◽  
T. A. Shumatova ◽  
L. A. Grigoryan ◽  
A. V. Gordeets
Keyword(s):  
Food Allergy ◽  
Intestinal Permeability ◽  
Oral Tolerance ◽  
Intestinal Barrier ◽  
Molecular Entity ◽  
Intestinal Epithelial ◽  
Intestinal Epithelial Barrier ◽  
Pathological Conditions ◽  
Diagnostic Criterion

Summary: The study represents a review of publications covering molecular entity of intestinal permeability and changes causing its disorders. The current concepts on intestinal barrier, tight joints (TJ) and intestinal permeability under normal and pathological conditions are covered. Special attention has been given to molecular unions of tight joints; a role of dysregulation of the components of the TJ complex in the formation of oral tolerance and food allergy is disclosed. It is shown that the assessment of the intestinal epithelial barrier condition can be a significant diagnostic criterion to control the disease and to assess the effectiveness of treatment.

scholarly journals Antigen-Presenting Cells in Food Tolerance and Allergy

2021 ◽  
Vol 11 ◽  
Author(s):  
Elise G. Liu ◽  
Xiangyun Yin ◽  
Anush Swaminathan ◽  
Stephanie C. Eisenbarth
Keyword(s):  
Food Allergy ◽  
T Cell ◽  
Oral Tolerance ◽  
Immunoglobulin E ◽  
Antigen Presenting Cells ◽  
Western World ◽  
Dominant Form ◽  
Food Antigens ◽  
Different Types ◽  
Antigen Presenting

Food allergy now affects 6%–8% of children in the Western world; despite this, we understand little about why certain people become sensitized to food allergens. The dominant form of food allergy is mediated by food-specific immunoglobulin E (IgE) antibodies, which can cause a variety of symptoms, including life-threatening anaphylaxis. A central step in this immune response to food antigens that differentiates tolerance from allergy is the initial priming of T cells by antigen-presenting cells (APCs), primarily different types of dendritic cells (DCs). DCs, along with monocyte and macrophage populations, dictate oral tolerance versus allergy by shaping the T cell and subsequent B cell antibody response. A growing body of literature has shed light on the conditions under which antigen presentation occurs and how different types of T cell responses are induced by different APCs. We will review APC subsets in the gut and discuss mechanisms of APC-induced oral tolerance versus allergy to food identified using mouse models and patient samples.

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