The outbreak of the COVID-19 epidemic has had a great impact on economic and social development, the task of poverty alleviation has become more difficult, and the strategy of rural revitalization is facing greater challenges. Higher vocational colleges undertake the important mission of training and conveying advanced skilled talents needed for the country's economic and social development, and are bound to assume their own responsibilities in the strategy of rural revitalization. The innovation and entrepreneurship education for college students promoted by higher vocational colleges in recent years provides a feasible implementation path for higher vocational colleges to participate in the country's rural revitalization strategy. Based on the background of the national rural revitalization strategy, this paper points out the great significance of the integration of innovation and entrepreneurship education in higher vocational colleges into the rural revitalization strategy, and puts forward specific measures to realize the integration of innovation and entrepreneurship education into the rural revitalization strategy.