Application of Solid Carbon Electrodes in Voltammetric (Bio)analysis of Selected Cytostatic Drugs

2022 ◽  
pp. 1-22
Author(s):  
Mariola Brycht ◽  
Andrzej Leniart ◽  
Sławomira Skrzypek
Keyword(s):  
Carbon Electrodes ◽  
Solid Carbon ◽  
Cytostatic Drugs

Comparative Electrochemical Study of Some Phenothiazines with Carbon Paste, Solid Carbon Paste and Glass-Like Carbon Electrodes

2000 ◽  
Vol 65 (6) ◽  
pp. 1014-1028 ◽  
Author(s):  
Robert V. Sandulescu ◽  
Simona M. Mirel ◽  
Radu N. Oprean ◽  
Simion Lotrean
Keyword(s):  
Modified Electrodes ◽  
Linear Sweep Voltammetry ◽  
Pharmaceutical Formulations ◽  
Oxidation Potential ◽  
Electrochemical Study ◽  
Carbon Electrodes ◽  
Potential Range ◽  
Solid Carbon ◽  
Carbon Paste ◽  
Linear Sweep

In order to obtain modified electrodes with phenothiazines and to develop electrochemical methods for their determination in pharmaceutical formulations, promazine maleate, promethazine maleate and levomepromazine, were studied by linear sweep voltammetry using different types of working electrodes: carbon paste, solid carbon paste and glass-like carbon electrodes. A comparative electrochemical study of the above mentioned pheno- thiazines was performed in aqueous-alcoholic solutions, investigating the influence of pH, ionic strength and concentration on the current-potential curves. Linear sweep voltammetry in potential range from -0.1 to +1.3 V revealed that the oxidation potential and the current, strongly depend on the type of electrode and pH, the best results being obtained in acid buffer (pH 1.0). The current intensity depending linearly on the concentration in the range of 2.5·10-5-5·10-4 M promazine maleate, 2.5·10-5-2.5·10-4 M promethazine maleate and 6.2·10-5-1.2·10-3 M levomepromazine permits the development of electroanalytical methods to determine these phenothiazines in pharmaceuticals. The electrochemical determination yielded results comparable with spectrophotometric methods. Linear sweep voltammetry of carbon paste electrodes modified by incorporation of phenothiazines opens the possibility to use them as mediators in the design of some enzyme selective electrodes.

SPECTRAL CHARACTERIZATION OF REDOX-ACTIVE PRUSSIAN BLUE ON METALLATED PLASMA POLYMER SURFACE MODIFIED CARBON ELECTRODES USING PHOTOTHERMAL DETECTION

1983 ◽  
Vol 44 (C6) ◽  
pp. C6-285-C6-290 ◽  
Author(s):  
J. W. Childers ◽  
A. L. Crumbliss ◽  
P. S. Lugg ◽  
R. A. Palmer ◽  
N. Morosoff ◽  
...  
Keyword(s):  
Prussian Blue ◽  
Polymer Surface ◽  
Spectral Characterization ◽  
Plasma Polymer ◽  
Carbon Electrodes ◽  
Redox Active ◽  
Surface Modified

A Novel Approach of Plasma Nitrocarburizing Using a Solid Carbon Active Screen – a Proof of Concept

2017 ◽  
Vol 72 (5) ◽  
pp. 254-259 ◽  
Author(s):  
I. Burlacov ◽  
S. Hamann ◽  
H.-J. Spies ◽  
A. Dalke ◽  
J. Röpcke ◽  
...  
Keyword(s):  
Solid Carbon ◽  
Proof Of Concept ◽  
Novel Approach ◽  
Plasma Nitrocarburizing ◽  
Active Screen

Protective influence of coded amino acids on the development of liver tissue culture in the presence of cytostatic

2020 ◽  
pp. 48-53
Author(s):  
N. I. Chalisova ◽  
V. K. Kozlov ◽  
A. B. Mulik ◽  
E. P. Zatsepin ◽  
T. A. Kostrova
Keyword(s):  
Amino Acids ◽  
Tissue Culture ◽  
Side Effects ◽  
Liver Tissue ◽  
Organotypic Culture ◽  
Growth Zone ◽  
Inhibitory Effect ◽  
Cytostatic Drugs ◽  
Urgent Problem ◽  
Combined Exposure

An urgent problem is the search for substances that can provide a protective effect in cases of DNA synthesis and repair disorders that arise as a result of side effects of cytostatic drugs used in the treatment of cancer. The aim of this work was to study the effect of 20 encoded amino acids in the presence of Cyclophosphane on the development of organotypic culture of rat liver tissue. The results obtained indicate that Cyclophosphane; which simulates the action of such cytostatic substances; inhibits cell proliferation in the liver tissue. It was also found that the encoded amino acids: asparagine; arginine; and glutamic acid; eliminate the inhibitory effect of Cyclophosphane in liver tissue culture. The growth zone of explants after combined exposure to Cyclophosphane (whose isolated action suppressed the growth zone) and these amino acids increased significantly and reached control values. Thus; the experimental data create the basis for the development of methods for the therapeutic use of the three studied amino acids for the removal of side effects in the treatment with cytostatic drugs.

ABATEMENT OF ANTICANCER DRUGS VIA ELECTROCHEMICAL OXIDATION PROCESS: A REVIEW

2020 ◽  
pp. 1-4
Author(s):  
CHARULATA SIVODIA ◽  
ALOK SINHA
Keyword(s):  
Anticancer Drugs ◽  
Cell Function ◽  
Electrochemical Techniques ◽  
Aquatic Organisms ◽  
Pharmaceutical Drugs ◽  
Cytostatic Drugs ◽  
Cancerous Cell ◽  
Pharmaceutical Removal ◽  
Mutagenic Effects ◽  
Made In

The advancement made in biomedical industry upsurges the consumption rate of pharmaceutical drugs. The lack of proper monitoring and regulation methods leads to the unregulated discharge of pharmaceuticals in wastewater, where it can affect the aquatic organisms. Anticancer drugs are also known as cytostatic drugs mainly used for the treatment of cancer by disrupting the cell function and prevent multiplication of cancerous cell. Therefore, anticancer drugs are suspected to pose potential risk on environment by influencing mutagenic effects on the cells of aquatic organisms. An extensive research has been already made in the field of pharmaceutical removal, however their application on the removal of anticancer drugs is limited. This review paper elucidates about different electrochemical techniques for the mitigation of cytostatic drugs.

Prostate Cancer, miRNAs, Metallothioneins and Resistance to Cytostatic Drugs

2013 ◽  
Vol 20 (4) ◽  
pp. 534-544 ◽  
Author(s):  
V. Pekarik ◽  
J. Gumulec ◽  
M. Masarik ◽  
R. Kizek ◽  
V. Adam
Keyword(s):  
Prostate Cancer ◽  
Cytostatic Drugs

Carbon electrodes for the electroreduction of air oxygen

1971 ◽  
Vol 36 (2) ◽  
pp. 638-650 ◽  
Author(s):  
J. Mrha ◽  
M. Musilová ◽  
J. Jindra
Keyword(s):  
Carbon Electrodes
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