Development and Characterization of Porous Calcium Phosphate Cement Using α-Tricalcium Phosphate Bead

A calcium phosphate cement (CPC) scaffold has been used to repair bone defects, but its low compressive strength and poor osteogenesis greatly hinder its clinical application.

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Studies on Non-Quenched Calcium Phosphate Cement: Influences of Quenching and Milling on Setting Characteristic

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.330-332.39 ◽

2007 ◽

Vol 330-332 ◽

pp. 39-42 ◽

Cited By ~ 2

Author(s):

Xue Jiang Wang ◽

Yu Bao Li ◽

John A. Jansen ◽

Shi Hong Li ◽

Joop G.C. Wolke

Keyword(s):

Particle Size ◽

Calcium Phosphate ◽

Surface Area ◽

Calcium Phosphate Cement ◽

Tricalcium Phosphate ◽

Hydrated Layer ◽

Initial Setting

The aim of this study is to explore the effects of quenching and milling processing on setting property of calcium phosphate cement (CPC). For this purpose, non-quenched α-tricalcium phosphate (α-TCP) and quenched α-TCP were synthesized and their corresponding cement systems were prepared. The particle size of α-TCP powder was introduced as a variable. Then, setting properties of these CPC systems were estimated. By a comparison between non-quenched CPC and the quenched one, it is found that milling processing mainly influences the initial setting stage by decreasing reactant particle size whereas the quenching treatment affects the final setting stage by changing α-TCP content, which supports that CPC setting initially depends on the surface area of reactants and subsequently on the diffusion through the hydrated layer formed around the reactants.

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Characterization of bone repair in rat femur after treatment with calcium phosphate cement and autogenous bone graft

Head & Face Medicine ◽

10.1186/1746-160x-6-10 ◽

2010 ◽

Vol 6 (1) ◽

Cited By ~ 6

Author(s):

Edela Puricelli ◽

Adriana Corsetti ◽

Deise Ponzoni ◽

Gustavo L. Martins ◽

Mauro G. Leite ◽

...

Keyword(s):

Calcium Phosphate ◽

Bone Graft ◽

Calcium Phosphate Cement ◽

Bone Repair ◽

Rat Femur ◽

Autogenous Bone Graft ◽

Autogenous Bone

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Stearate Salts as Brushite Bone Cement Setting Retardants

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.284-286.19 ◽

2005 ◽

Vol 284-286 ◽

pp. 19-22 ◽

Cited By ~ 2

Author(s):

M.P. Hofmann ◽

Uwe Gbureck ◽

Liam M. Grover ◽

J.E. Barralet

Keyword(s):

Compressive Strength ◽

Calcium Phosphate ◽

Bone Cement ◽

Calcium Phosphate Cement ◽

Tricalcium Phosphate ◽

Sodium Stearate ◽

Setting Times ◽

Powder Component ◽

Cement System ◽

Cement Setting

This study sought to examine the efficiency of coating cement powder reactants in order to reduce the solubility rate of reactants and thereby increase setting times of cement systems. In this investigation magnesium and sodium stearate salts were used to coat the highly soluble monocalcium phosphate monohydrate (MCPM) powder component of a hydraulic brushite forming calcium phosphate cement system with b-tricalcium phosphate (b-TCP) as other component. The results showed that stearate coating of the MCPM reactant could lead to a 100% increase in setting and working times without affecting compressive strength of the set cement when applied with the appropriate P/L-ratio.

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Fully-Interconnected Pore Forming Calcium Phosphate Cement

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.493-494.832 ◽

2011 ◽

Vol 493-494 ◽

pp. 832-835 ◽

Cited By ~ 6

Author(s):

Ishikawa Kunio ◽

Kanji Tsuru ◽

Trung Kien Pham ◽

Michito Maruta ◽

Shigeki Matsuya

Keyword(s):

Calcium Phosphate ◽

Porous Structure ◽

Calcium Phosphate Cement ◽

Tricalcium Phosphate ◽

Porous Body ◽

Phosphate Solution ◽

Dicalcium Phosphate Dihydrate ◽

Phosphate Dihydrate ◽

Bone Defect Reconstruction ◽

Interconnected Pore

Calcium phosphate cement that foams fully-interconnected porous structure along with its gradual replacement to bone may be ideal for bone defect reconstruction. In the present study, α-tricalcium phosphate (αTCP) microspheres were exposed to acidic calcium phosphate solution. It was found that the αTCP microspheres set in approximately 10 min to form fully-interconnected porous structure. The porosity was approximately 50% and the pore size was 300µm. The surface of the porous body was dicalcium phosphate dihydrate whereas the inside was αTCP.

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