The need for interdisciplinary studies to address the complex issues, too broad to deal adequately by a single discipline, is widely acknowledged in literature. Many issues in modern days such as climate change, food security and energy crisis, are interdisciplinary in nature. The success of interdisciplinary studies depends on ‘collaboration' and ‘synthesizing mind' among researchers in different disciplines. Research studies have identified disciplinary focus, assumptions, theories and practices, research design, and methodological pluralism as the major sources of conflict in an interdisciplinary context. In particular, the chapter discusses the various methodological barriers such as differing methodological approach, conflicting research findings, methodological pluralism, terminological problems, time barriers, and diverse motivations in interdisciplinary studies. Based on analysis, the chapter provides few recommendations to address methodological barriers and to promote collaboration and integration among members from various disciplines involved in interdisciplinary studies.