Drug–Drug Interaction Studies

Lurasidone drug-drug interaction studies: a comprehensive review

Drug Metabolism and Drug Interactions ◽

10.1515/dmdi-2014-0005 ◽

2014 ◽

Vol 29 (3) ◽

Cited By ~ 14

Author(s):

Yu-Yuan Chiu ◽

Larry Ereshefsky ◽

Sheldon H. Preskorn ◽

Nagaraju Poola ◽

Antony Loebel

Keyword(s):

Drug Interaction ◽

Comprehensive Review ◽

Interaction Studies ◽

Drug Drug Interaction

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Is It Time to Use Modeling of Cellular Transporter Homeostasis to Inform Drug-Drug Interaction Studies: Theoretical Considerations

The AAPS Journal ◽

10.1208/s12248-021-00635-4 ◽

2021 ◽

Vol 23 (5) ◽

Author(s):

Roberto A. Abbiati ◽

M. Guillaume Wientjes ◽

Jessie L.-S. Au

Keyword(s):

Drug Interaction ◽

Interaction Studies ◽

Drug Drug Interaction ◽

Theoretical Considerations

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Effects of Strong CYP3A Inhibition and Induction on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor: Results of Drug-Drug Interaction Studies in Patients With Advanced Solid Tumors or Lymphoma and a Physiologically Based Pharmacokinetic Ana

The Journal of Clinical Pharmacology ◽

10.1002/jcph.988 ◽

2017 ◽

Vol 58 (2) ◽

pp. 180-192 ◽

Cited By ~ 20

Author(s):

Neeraj Gupta ◽

Michael J. Hanley ◽

Karthik Venkatakrishnan ◽

Alberto Bessudo ◽

Drew W. Rasco ◽

...

Keyword(s):

Drug Interaction ◽

Solid Tumors ◽

Proteasome Inhibitor ◽

Advanced Solid Tumors ◽

Physiologically Based Pharmacokinetic ◽

Interaction Studies ◽

Physiologically Based ◽

Drug Drug Interaction

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Drug-Drug Interaction Studies

10.1007/springerreference_205022 ◽

2012 ◽

Keyword(s):

Drug Interaction ◽

Interaction Studies ◽

Drug Drug Interaction

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Results from Drug–Drug Interaction Studies In Vitro and In Vivo Investigating the Effect of Finerenone on the Pharmacokinetics of Comedications

European Journal of Drug Metabolism and Pharmacokinetics ◽

10.1007/s13318-020-00610-y ◽

2020 ◽

Vol 45 (4) ◽

pp. 433-444

Author(s):

Roland Heinig ◽

Michael Gerisch ◽

Michaela Bairlein ◽

Johannes Nagelschmitz ◽

Stephanie Loewen

Keyword(s):

Drug Interaction ◽

Interaction Studies ◽

Drug Drug Interaction

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In Vitro Drug-Drug Interaction Studies with the Antiemetic Drug Netupitant and its Major Metabolites M1 and M2, Involving Several Human Cytochrome P450 Isoenzymes

Annals of Oncology ◽

10.1016/s0923-7534(20)34168-5 ◽

2012 ◽

Vol 23 ◽

pp. ix520 ◽

Cited By ~ 5

Author(s):

C. Giuliano ◽

E. Lovati ◽

C. Funk ◽

M. Potthast ◽

C. Pietra

Keyword(s):

Cytochrome P450 ◽

Drug Interaction ◽

Antiemetic Drug ◽

Interaction Studies ◽

Human Cytochrome ◽

Drug Drug Interaction

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Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies

The AAPS Journal ◽

10.1208/s12248-019-0344-8 ◽

2019 ◽

Vol 21 (5) ◽

Cited By ~ 3

Author(s):

Andrea Treyer ◽

Mohammed Ullah ◽

Neil Parrott ◽

Birgit Molitor ◽

Stephen Fowler ◽

...

Keyword(s):

Drug Interaction ◽

Metabolic Drug ◽

Interaction Studies ◽

Intracellular Concentrations ◽

Drug Drug Interaction

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Drug–Drug Interaction Studies

Drug Discovery and Evaluation: Methods in Clinical Pharmacology ◽

10.1007/978-3-319-56637-5_13-1 ◽

2017 ◽

pp. 1-20

Author(s):

Peter Stopfer

Keyword(s):

Drug Interaction ◽

Interaction Studies ◽

Drug Drug Interaction

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Drug–Drug Interaction Studies Between Hepatitis C Virus Antivirals Sofosbuvir/Velpatasvir and Boosted and Unboosted Human Immunodeficiency Virus Antiretroviral Regimens in Healthy Volunteers

Clinical Infectious Diseases ◽

10.1093/cid/ciy201 ◽

2018 ◽

Vol 67 (6) ◽

pp. 934-940 ◽

Cited By ~ 9

Author(s):

Erik Mogalian ◽

Luisa M Stamm ◽

Anu Osinusi ◽

Diana M Brainard ◽

Gong Shen ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Drug Interaction ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Healthy Volunteers ◽

Interaction Studies ◽

Immunodeficiency Virus ◽

Drug Drug Interaction

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Simultaneous determination of canrenone, digoxin and tolvaptan by UHPLC–MS/MS: application in heart failure patients

Bioanalysis ◽

10.4155/bio-2020-0037 ◽

2020 ◽

Vol 12 (9) ◽

pp. 569-582

Author(s):

Peng Guo ◽

Qiucheng Liang ◽

Juntao Zheng ◽

Jinmin Chen ◽

Yanping Guan ◽

...

Keyword(s):

Heart Failure ◽

Drug Interaction ◽

Simultaneous Determination ◽

Isocratic Elution ◽

Heart Failure Patients ◽

Interaction Studies ◽

Related Drug ◽

Ionization Mode ◽

Drug Drug Interaction

Aim: Heart failure patients are frequently given comedication of digoxin and diuretics like spironolactone and tolvaptan. A UHPLC–MS/MS assay for determining canrenone (main active metabolite of spironolactone), digoxin and tolvaptan simultaneously should be developed so as to support related drug–drug interaction studies. Results: A UHPLC–MS/MS method for simultaneous determination of these three drugs in human plasma was established and fully verified as per CFDA guidelines. Chromatographic separation was achieved using a 4-min isocratic elution. Mass analyses were performed under positive electrospray ionization mode. The calibration curves were established over 1.0–400.0 ng/ml for canrenone and tolvaptan while over 0.1–40.0 ng/ml for digoxin. Conclusion: The developed method was feasible in detecting concentration and related drug–drug interaction studies.

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