Towards the Neuropsychological Diagnosis of Alzheimer’s Disease: A Hybrid Model in Decision Making

Author(s):  
Ana Karoline Araujo de Castro ◽  
Placido Rogerio Pinheiro ◽  
Mirian Caliope Dantas Pinheiro
2010 ◽  
Vol 1 (3) ◽  
pp. 331 ◽  
Author(s):  
Ana Karoline De Castro ◽  
Placido Rogerio Pinheiro ◽  
Mirian Caliope Dantas Pinheiro ◽  
Isabelle Tamanini

Author(s):  
Ana Karoline Araújo de Castro ◽  
Plácido Rogério Pinheiro ◽  
Mirian Calíope Dantas Pinheiro ◽  
Isabelle Tamanini

Author(s):  
Ana Karoline Araujo de Castro ◽  
Placido Rogerio Pinheiro ◽  
Mirian Caliope Dantas Pinheiro ◽  
Isabelle Tamanini

Author(s):  
Kristina M. Kokorelias ◽  
Monique A. M. Gignac ◽  
Gary Naglie ◽  
Nira Rittenberg ◽  
Jill I. Cameron

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S477-S478
Author(s):  
Evan Z Gross ◽  
Rebecca J Campbell ◽  
LaToya Hall ◽  
Peter Lichtenberg

Abstract Financial decision making self-efficacy (FDMSE) is a novel construct that may influence how older adults make financial decisions. Our previous research with a community sample of older adults demonstrated that cognitive functioning and suspected history of financial exploitation were both associated with low FDMSE. We sought to replicate these findings in two clinical samples of older adults: people with mild cognitive impairment (MCI) or probable Alzheimer’s disease (PAD) and current victims of scams or exploitation as determined by a financial coach. Samples were obtained from the Michigan Alzheimer’s Disease Center and a financial coaching intervention study. All participants completed a 4-item FDMSE measure. One-way ANOVAs, t-tests and chi-square tests were conducted to test for group differences with controls on demographics. There was a main effect of cognitive status on FDMSE, F(2,138) = 8.10, p < .001, which was driven by higher FDMSE in the healthy group (N = 63) than the MCI (N = 76) or PAD (N = 28) groups. Similarly, scam victims (N = 25) had significantly lower FDMSE than non-exploited (N = 25) peers, t(48)=2.33, p < 05. Cognitive impairment and current financial scams are both associated with low FDMSE levels. Low FDMSE may exacerbate cognitive and psychosocial vulnerabilities that contribute to risk for poor financial decisions among older adults. Future interventions to enhance FDMSE may help older adults make better decisions despite changes in thinking abilities or previous negative financial experiences.


2020 ◽  
Vol 15 (6) ◽  
pp. 681-694
Author(s):  
Aurélie L Manuel ◽  
Daniel Roquet ◽  
Ramon Landin-Romero ◽  
Fiona Kumfor ◽  
Rebekah M Ahmed ◽  
...  

Abstract Negative and positive emotions are known to shape decision-making toward more or less impulsive responses, respectively. Decision-making and emotion processing are underpinned by shared brain regions including the ventromedial prefrontal cortex (vmPFC) and the amygdala. How these processes interact at the behavioral and brain levels is still unclear. We used a lesion model to address this question. Study participants included individuals diagnosed with behavioral-variant frontotemporal dementia (bvFTD, n = 18), who typically present deficits in decision-making/emotion processing and atrophy of the vmPFC, individuals with Alzheimer’s disease (AD, n = 12) who present with atrophy in limbic structures and age-matched healthy controls (CTRL, n = 15). Prior to each choice on the delay discounting task participants were cued with a positive, negative or neutral picture and asked to vividly imagine witnessing the event. As hypothesized, our findings showed that bvFTD patients were more impulsive than AD patients and CTRL and did not show any emotion-related modulation of delay discounting rate. In contrast, AD patients showed increased impulsivity when primed by negative emotion. This increased impulsivity was associated with reduced integrity of bilateral amygdala in AD but not in bvFTD. Altogether, our results indicate that decision-making and emotion interact at the level of the amygdala supporting findings from animal studies.


2013 ◽  
Vol 2 (3) ◽  
pp. 328-335 ◽  
Author(s):  
Pascal Hot ◽  
Kylee T. Ramdeen ◽  
Céline Borg ◽  
Thierry Bollon ◽  
Pascal Couturier

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