Prognostic Factors and Patterns of Failure in Childhood Acute Myeloid Leukemia: Experience on Pediatric Oncology Group Study # 8821

2001 ◽  
pp. 493-498
Author(s):  
Y. Ravindranath ◽  
M. Chang ◽  
S. Raimondi ◽  
A. J. Carroll ◽  
C. P. Steuber ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Prognostic Factors ◽  
Pediatric Oncology ◽  
Myeloid Leukemia ◽  
Oncology Group ◽  
Patterns Of Failure ◽  
Oncology Group Study ◽  
Childhood Acute Myeloid Leukemia ◽  
Pediatric Oncology Group ◽  
Acute Myeloid

RAS gene mutations in childhood acute myeloid leukemia: A pediatric oncology group study

1990 ◽  
Vol 2 (2) ◽  
pp. 159-162 ◽  
Author(s):  
Bert Vogelstein ◽  
Curt I. Civin ◽  
Antonette C. Preisinger ◽  
Jeffrey P. Krischer ◽  
Philip Steuber ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Pediatric Oncology ◽  
Myeloid Leukemia ◽  
Gene Mutations ◽  
Oncology Group ◽  
Ras Gene ◽  
Oncology Group Study ◽  
Childhood Acute Myeloid Leukemia ◽  
Pediatric Oncology Group ◽  
Acute Myeloid

scholarly journals Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: experience on Pediatric Oncology Group AML Study 8498 [see comments]

Blood ◽  
1992 ◽  
Vol 80 (9) ◽  
pp. 2210-2214 ◽  
Author(s):  
Y Ravindranath ◽  
E Abella ◽  
JP Krischer ◽  
J Wiley ◽  
S Inoue ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
Pediatric Oncology ◽  
Myeloid Leukemia ◽  
Oncology Group ◽  
Blood Cell Count ◽  
Pediatric Oncology Group ◽  
Acute Myeloid

Abstract The treatment of acute myeloid leukemia (AML) in children with Down's syndrome (DS) has engendered considerable controversy. Because of the concerns for toxicity and increased rate of infections, treatment approaches varied considerably in the past with mixed results. However, experience on the recently completed Pediatric Oncology Group (POG) 8498 AML study suggests that DS children with AML constitute a distinct subgroup that responds well to therapy. Twelve of 285 children on POG 8498 (protocol for newly diagnosed AML) had DS. Children with DS and AML were predominantly male (9 of 12) and were quite younger at diagnosis (< 24 months in 10). The white blood cell count was less than 50 x 10(3)/microL in all 12 and French-American-British types M6 and M7 were frequent (5 of 12). An abnormal cytogenetic marker, in addition to constitutional trisomy 21, was present in 9 of 12 and involved chromosome 8 in 4 of 9. All cases studied (n = 5) were positive for myeloid cell surface markers (CD33, CD13, or CD11b) and, interestingly, were also positive for the CD7 antigen. Chemotherapy included daunorubicin, cytarabine (Ara-C), and 6-thioguanine for remission induction and featured high-dose Ara-C (3 g/m2 per dose) with or without L-asparaginase early in remission. Compared with children without DS, children with DS had a superior event-free survival (EFS at 4 years 100% v 28% +/- 6.2%; P = .003). The EFS remained superior even when compared with non-DS children less than 2 years of age with a white blood cell count less than 10 x 100,000/microL (100% v 48% +/- 17.3%; P = .01).

scholarly journals Acute myeloid leukemia (AML) in Down's syndrome is highly responsive to chemotherapy: experience on Pediatric Oncology Group AML Study 8498 [see comments]

Blood ◽  
1992 ◽  
Vol 80 (9) ◽  
pp. 2210-2214 ◽  
Author(s):  
Y Ravindranath ◽  
E Abella ◽  
JP Krischer ◽  
J Wiley ◽  
S Inoue ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Blood Cell ◽  
Cell Count ◽  
White Blood Cell Count ◽  
Pediatric Oncology ◽  
Myeloid Leukemia ◽  
Oncology Group ◽  
Blood Cell Count ◽  
Pediatric Oncology Group ◽  
Acute Myeloid

The treatment of acute myeloid leukemia (AML) in children with Down's syndrome (DS) has engendered considerable controversy. Because of the concerns for toxicity and increased rate of infections, treatment approaches varied considerably in the past with mixed results. However, experience on the recently completed Pediatric Oncology Group (POG) 8498 AML study suggests that DS children with AML constitute a distinct subgroup that responds well to therapy. Twelve of 285 children on POG 8498 (protocol for newly diagnosed AML) had DS. Children with DS and AML were predominantly male (9 of 12) and were quite younger at diagnosis (< 24 months in 10). The white blood cell count was less than 50 x 10(3)/microL in all 12 and French-American-British types M6 and M7 were frequent (5 of 12). An abnormal cytogenetic marker, in addition to constitutional trisomy 21, was present in 9 of 12 and involved chromosome 8 in 4 of 9. All cases studied (n = 5) were positive for myeloid cell surface markers (CD33, CD13, or CD11b) and, interestingly, were also positive for the CD7 antigen. Chemotherapy included daunorubicin, cytarabine (Ara-C), and 6-thioguanine for remission induction and featured high-dose Ara-C (3 g/m2 per dose) with or without L-asparaginase early in remission. Compared with children without DS, children with DS had a superior event-free survival (EFS at 4 years 100% v 28% +/- 6.2%; P = .003). The EFS remained superior even when compared with non-DS children less than 2 years of age with a white blood cell count less than 10 x 100,000/microL (100% v 48% +/- 17.3%; P = .01).

scholarly journals Southwestern Oncology Group pretreatment risk criteria as predictive or prognostic factors in acute myeloid leukemia

2017 ◽  
Vol 6 (3) ◽  
pp. 384-388 ◽  
Author(s):  
Ana Espirito Santo ◽  
Sergio Chacim ◽  
Isabel Ferreira ◽  
Luis Leite ◽  
Claudia Moreira ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Prognostic Factors ◽  
Myeloid Leukemia ◽  
Oncology Group ◽  
Risk Criteria ◽  
Acute Myeloid

scholarly journals Prognostic Factors in Childhood Acute Myeloid Leukemia; Experience from A Developing Country

2020 ◽  
Vol 3 (5) ◽  
Author(s):  
Tariq Ghafoor ◽  
Sumaira Khalil ◽  
Tanzeela Farah ◽  
Shakeel Ahmed ◽  
Imtenan Sharif
Keyword(s):  
Acute Myeloid Leukemia ◽  
Prognostic Factors ◽  
Developing Country ◽  
Myeloid Leukemia ◽  
Childhood Acute Myeloid Leukemia ◽  
Acute Myeloid
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