Sympathetic Nervous Activity, Noradrenaline Reactivity, and Blood Pressure Control

1980 ◽  
pp. 15-21 ◽  
Author(s):  
A. Distler ◽  
Th. Philipp ◽  
B. Lüth ◽  
U. Cordes
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Control ◽  
Nervous Activity ◽  
Pressure Control ◽  
Sympathetic Nervous Activity ◽  
Sympathetic Nervous

scholarly journals Highs and lows of sympathetic neurocardiovascular transduction: influence of altitude acclimatization and adaptation

2020 ◽  
Vol 319 (6) ◽  
pp. H1240-H1252 ◽  
Author(s):  
Lindsey F Berthelsen ◽  
Graham M. Fraser ◽  
Lydia L. Simpson ◽  
Emily R. Vanden Berg ◽  
Stephen A. Busch ◽  
...  
Keyword(s):  
Blood Pressure ◽  
High Altitude ◽  
Sympathetic Activity ◽  
Nervous Activity ◽  
Pressure Control ◽  
Sympathetic Nervous Activity ◽  
Pressure Regulation ◽  
Sympathetic Activation ◽  
Data Set ◽  
Sympathetic Nervous

This study has identified that sympathetically mediated blood pressure regulation is reduced following ascent to high altitude. Additionally, we show that high-altitude Andean natives have reduced blood pressure responsiveness to sympathetic nervous activity (SNA) outflow compared with Nepalese Sherpa. However, basal sympathetic activity is inversely related to the magnitude of SNA-mediated fluctuations in blood pressure regardless of population or condition. These data set a foundation to explore more precise mechanisms of blood pressure control under conditions of persistent sympathetic activation and hypoxia.

Interactions between ANG II, sympathetic nervous system, and baroreceptor reflexes in regulation of blood pressure

1992 ◽  
Vol 262 (6) ◽  
pp. E763-E778 ◽  
Author(s):  
I. A. Reid
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
Blood Pressure Control ◽  
Cardiovascular Responses ◽  
Pressure Control ◽  
Ang Ii ◽  
Arterial Blood ◽  
Baroreceptor Reflexes ◽  
Sympathetic Nervous

The renin-angiotensin system plays an important role in the regulation of arterial blood pressure and in the development of some forms of clinical and experimental hypertension. It is an important blood pressure control system in its own right but also interacts extensively with other blood pressure control systems, including the sympathetic nervous system and the baroreceptor reflexes. Angiotensin (ANG) II exerts several actions on the sympathetic nervous system. These include a central action to increase sympathetic outflow, stimulatory effects on sympathetic ganglia and the adrenal medulla, and actions at sympathetic nerve endings that serve to facilitate sympathetic neurotransmission. ANG II also interacts with baroreceptor reflexes. For example, it acts centrally to modulate the baroreflex control of heart rate, and this accounts for its ability to increase blood pressure without causing a reflex bradycardia. The physiological significance of these actions of ANG II is not fully understood. Most evidence indicates that the actions of ANG to enhance sympathetic activity do not contribute significantly to the pressor response to exogenous ANG II. On the other hand, there is considerable evidence that the actions of endogenous ANG II on the sympathetic nervous system enhance the cardiovascular responses elicited by activation of the sympathetic nervous system.

Abstract 5430: Obstructive Sleep Apnoea Exacerbates Muscular Sympathetic Nervous Activity in Patients with Metabolic Syndrome

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Ivani C Trombetta ◽  
Cristiane M Nunes ◽  
Luciano F Drager ◽  
Raffael F Fraga ◽  
Maria Janieire N Alves ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Heart Rate ◽  
Oxygen Saturation ◽  
Obstructive Sleep Apnoea ◽  
Nervous Activity ◽  
Sleep Apnoea ◽  
Sympathetic Nervous Activity ◽  
Obstructive Sleep ◽  
Sympathetic Nervous

Obstructive sleep apnoea (OSA) and metabolic syndrome (MetS) independently increases muscular sympathetic nervous activity (MSNA). Unknown is whether OSA has an additive effect on MSNA in patients with MetS. We tested the hypothesis that: OSA would have an additive effect on MSNA in patients with MetS. In addition, we studied whether the increase in MSNA in patients with MetS is associated with alteration in arterial baroreflex sensitivity (BRS). Twenty four patients with MetS diagnosed according ATP-III were divided in two groups: MetS+OSA (n=14) and MetS (n=10). They were matched for age, body mass index, waist circumference, and metabolic profile: OSA was defined by an apnoea/hypopnoea index (AHI)>15 events/hour by polysonography. MSNA was recorded directly from the peroneal nerve using the technique of microneurography. Blood pressure (BP) was monitored on a beat-by-beat basis (Finapress) and heart rate by ECG. BRS was analyzed by spontaneous BP and heart rate fluctuations. AHI was higher (42±9 vs. 7±1 events/h, P =0.0001) and minimum oxygen saturation lower (77±2 vs. 87±1 %, P =0.001) in MetS+OSA patients. Patients MetS+OSA had higher MSNA (55±3 vs. 43±2 bursts/100 beats, P =0.01) and systolic BP (158±4 vs.144±3 mmHg, P =0.01) when compared with patients with MetS without OSA. Further analysis showed that AHI and minimum oxygen saturation have significant correlation with MSNA (r=0.65; P =0.001 and r=−0.48; P =0.017, respectively). Patients with MetS+OSA had lower BRS for increases (7.8±0.9 vs. 13.4 ± 1.4 msec/mmHg, P =0.01) and decreases (7.2±0.9 vs. 13.2 ± 2.0 msec/mmHg, P =0.03) in blood pressure than patients with MetS without OSA. MSNA significantly correlated with BRS during spontaneous increases in blood pressure (r=−0.56, P =0.01). OSA exacerbates MSNA in patients with MetS. In addition, the augmented MSNA in patients with MetS+OSA is associated with reduced BRS. These findings suggest that OSA increases the risk for cardiovascular disease in patients with MetS.

HEMODYNAMIC REACTIONS IN CIVIL AVIATION PILOTS TO SIMULATOR TRAINING

2021 ◽  
Vol 55 (5) ◽  
pp. 25-30
Author(s):  
V.V. Serikov ◽  
◽  
E.V. Zibarev ◽  
O.I. Yushkova ◽  
Kh.T. Oniani ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Nervous Activity ◽  
Holter Monitoring ◽  
Simulator Training ◽  
Civil Aviation ◽  
Stress Index ◽  
Sympathetic Nervous Activity ◽  
Cardiovascular Monitoring ◽  
Sympathetic Nervous ◽  
Aviation Pilots

The paper presents the data of cardiovascular monitoring of civil pilots in the process of simulator training that included 24-hr BP and Holter monitoring and calculation of cardiac interval variation and Baevsky's stress index. Blood pressure increases correlated with a psycho-emotional stress level. Take-off and landing overstrained the cardiovascular system significantly. According to the Holter data, 42 % pilots had rhythmic disorders, ventricular and supraventricular extrasystoles; 50 % pilots had an expressed elevation of the sympathetic nervous activity.

Controlling Blood Pressure without Drugs – Developing New Strategies

2010 ◽  
Vol 6 (2) ◽  
pp. 18
Author(s):  
Markus P Schlaich ◽  
Murray D Esler ◽  
◽  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Control ◽  
Pressure Control ◽  
Therapeutic Strategies ◽  
Novel Device ◽  
Major Player ◽  
Treatment Of Hypertension ◽  
Sympathetic Nervous ◽  
Optimal Blood Pressure ◽  
New Strategies

Non-optimal blood pressure is the leading cause of death globally, and each year is responsible for seven million deaths. Current therapeutic strategies for hypertension are mainly based on lifestyle interventions and pharmacological approaches, but rates of blood pressure control remain unsatisfactory and additional options are required. In this context, novel device-based approaches specifically targeting the sympathetic nervous system as a major player in blood pressure control have recently been tested clinically with promising results. Device-based approaches may provide additional and more effective treatment of hypertension and its adverse consequences in the future.

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