Long-Term Clinical Effects of Verapamil in Patients with Hypertrophic Cardiomyopathy

1982 ◽  
pp. 187-202
Author(s):  
Douglas R. Rosing ◽  
John R. Condit ◽  
Barry J. Maron ◽  
Kenneth M. Kent ◽  
Martin B. Leon ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Clinical Effects

RF42 LONG TERM RESULTS OF SEPTAL MYECTOMY IN OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY

2018 ◽  
Vol 19 ◽  
pp. e76-00
Author(s):  
G. Saitto ◽  
F. Grimaldi ◽  
A. Varrica ◽  
A. Biondi ◽  
A. Garatti ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Long Term Results ◽  
Septal Myectomy ◽  
Obstructive Hypertrophic Cardiomyopathy

scholarly journals Prognostic value of mitral regurgitation in patients with asymmetric hypertrophic cardiomyopathy

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
M Tesic ◽  
L Travica ◽  
V Giga ◽  
D Trifunovic ◽  
I Jovanovic ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Mitral Valve ◽  
Mitral Regurgitation ◽  
Prognostic Value ◽  
Volume Index ◽  
Common Finding ◽  
Adequate Treatment ◽  
Group 2 ◽  
Group 1

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Since mitral regurgitation (MR) is a very common finding in patients with hypertrophic cardiomyopathy (HCM), the evaluation of the mitral valve anatomy and the degree of MR is of utmost importance in this population. However, data regarding the prognostic value of different degrees of MR in HCM remains scarce. Purpose The aim of this study was to determine whether the presence of a higher degree of MR affects: 1) long term prognosis; 2) clinical and echocardiographic presentation of HCM patients. Material and Methods We included prospectively 102 patients, diagnosed with primary asymmetric HCM. The degree of MR was determined echocardiographicaly according to current recommendations of the American Association of Echocardiography. According to the MR severity, patients were divided into 2 groups: Group 1 (n = 52) with no/trace or mild MR and Group 2 with moderate or moderate to severe MR. All patients had clinical and echocardiographic examination, 24-hour Holter ECG and NT pro BNP analysis performed. The primary outcome was a composite of: 1) HCM related death or sudden death; 2) hospitalization due to acute heart failure; 3) sustained ventricular tachycardia; 4) ischemic stroke. Results Patients with higher MR degree had more frequent chest pain (p = 0.039), syncope (p = 0.041) and NYHA II functional class (p < 0.001). Group 2 patients had mostly obstructive form of HCM (p < 0.001) with more frequent presence of previous atrial fibrillation (AF) (p = 0.032), as well as the new onset of AF (p = 0.014) compared to patients in Group 1. Patients with higher MR degree had significantly more SAM (p < 0.001) resulting in a more frequent eccentric MR jet (p < 0.001), along with calcified mitral annulus (p = 0.007), enlarged left atrial volume index (p < 0.001), and elevated right ventricular pressure (p = 0.001). As a result of higher MR grade, Group 2 had higher E/e" values (p < 0.001), elevated LV filling pressure (lateral E/e’ >10), as well as higher levels of NT pro BNP (p = 0.001). By Kaplan-Meier analysis we demonstrated that the event free survival rate during follow up of median 75 (IQR 48-103) months was significantly higher in Group 1 compared to the Group 2 (79% vs. 46%, p < 0.001), Figure 1. After adjustment for relevant confounders, moderate/moderate to severe MR remained as an independent predictor of adverse outcome (hazard ratio 2.58, 95% CI: 1.08-6.13, p < 0.001). Conclusion Presence of moderate, or moderate to severe MR was associated with poor long-term outcome of HCM patients. These results indicate the importance of an adequate MR assessment and detailed evaluation of the mitral valve anatomy in the prediction of complications and adequate treatment of patients with HCM. Abstract Figure.

scholarly journals Fecal Microbiota Transplant in Two Ulcerative Colitis Pediatric Cases: Gut Microbiota and Clinical Course Correlations

2020 ◽  
Vol 8 (10) ◽  
pp. 1486
Author(s):  
Andrea Quagliariello ◽  
Federica Del Chierico ◽  
Sofia Reddel ◽  
Alessandra Russo ◽  
Andrea Onetti Muda ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Clinical Effects ◽  
Phylogenetic Distance ◽  
Fecal Microbiota Transplant ◽  
Inflammatory Bowel ◽  
Clinical Conditions ◽  
And Control

Fecal microbiota transplantation (FMT) is a promising strategy in the management of inflammatory bowel disease (IBD). The clinical effects of this practice are still largely unknown and unpredictable. In this study, two children affected by mild and moderate ulcerative colitis (UC), were pre- and post-FMT monitored for clinical conditions and gut bacterial ecology. Microbiota profiling relied on receipts’ time-point profiles, donors and control cohorts’ baseline descriptions. After FMT, the improvement of clinical conditions was recorded for both patients. After 12 months, the mild UC patient was in clinical remission, while the moderate UC patient, after 12 weeks, had a clinical worsening. Ecological analyses highlighted an increase in microbiota richness and phylogenetic distance after FMT. This increase was mainly due to Collinsella aerofaciens and Eubacterium biforme, inherited by respective donors. Moreover, a decrease of Proteus and Blautia producta, and the increment of Parabacteroides, Mogibacteriaceae, Bacteroides eggerthi, Bacteroides plebeius, Ruminococcus bromii, and BBacteroidesovatus were associated with remission of the patient’s condition. FMT results in a long-term response in mild UC, while in the moderate form there is probably need for multiple FMT administrations. FMT leads to a decrease in potential pathogens and an increase in microorganisms correlated to remission status.

Apical Hypertrophic Cardiomyopathy in Childhood: A Long-Term Follow-Up Report of Two Cases

2008 ◽  
Vol 30 (3) ◽  
pp. 343-346 ◽  
Author(s):  
Tomoyuki Miyamoto ◽  
Hitoshi Horigome ◽  
Satoru Kawano ◽  
Ryo Sumazaki
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Apical Hypertrophic Cardiomyopathy ◽  
Long Term Follow Up

Long-Term Clinical Effects, Bioavailability, and Kinetics of Minoxidil in Relation to Renal Function

1978 ◽  
Vol 18 (10) ◽  
pp. 500-508 ◽  
Author(s):  
DAVID T. LOWENTHAL ◽  
GADDO ONESTI ◽  
ROBERT MUTTERPERL ◽  
MELTON APFRIME ◽  
EDUARDO W. MARTINEZ ◽  
...  
Keyword(s):  
Renal Function ◽  
Clinical Effects ◽  
Kinetics Of

scholarly journals Oral appliance in sleep apnea treatment: respiratory and clinical effects and long-term adherence

2016 ◽  
Vol 20 (2) ◽  
pp. 805-812 ◽  
Author(s):  
Patrick Bachour ◽  
Adel Bachour ◽  
Paula Kauppi ◽  
Paula Maasilta ◽  
Antti Mäkitie ◽  
...  
Keyword(s):  
Sleep Apnea ◽  
Oral Appliance ◽  
Clinical Effects ◽  
Sleep Apnea Treatment

scholarly journals Long-term outcome in patients with latent (Provocable) obstructive hypertrophic cardiomyopathy

2003 ◽  
Vol 41 (6) ◽  
pp. 146
Author(s):  
Maria J. Eriksson ◽  
Anna Woo ◽  
E. Douglas Wigle ◽  
David Focsaneanu ◽  
Paul Rakowski ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Obstructive Hypertrophic Cardiomyopathy
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