Overview: Infectious Agents as Etiologic Triggers of Autoimmune Disease

Introduction: the role of inflammation, autoimmune disease and infectious agents in development of leukaemia and lymphoma

Journal of Internal Medicine ◽

10.1111/j.1365-2796.2008.02028.x ◽

2008 ◽

Vol 264 (6) ◽

pp. 512-513 ◽

Cited By ~ 2

Author(s):

R. Rosenquist

Keyword(s):

Autoimmune Disease ◽

Infectious Agents

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Multiple Autoantigen Mimotopes of Infectious Agents Induce Autoimmune Arthritis and Uveitis in Lewis Rats

Clinical and Diagnostic Laboratory Immunology ◽

10.1128/cdli.12.5.677-679.2005 ◽

2005 ◽

Vol 12 (5) ◽

pp. 677-679 ◽

Cited By ~ 8

Author(s):

Gerhild Wildner ◽

Maria Diedrichs-Moehring

Keyword(s):

Amino Acid ◽

Autoimmune Disease ◽

Amino Acid Sequence ◽

Autoimmune Arthritis ◽

Infectious Agents ◽

Lewis Rats ◽

Sequence Homologies ◽

Antigenic Mimicry

ABSTRACT We found multimolecular antigenic mimicry of arthritogenic autoantigens and peptides from several other “self” or foreign antigens sharing amino acid sequence homologies. Many of these new mimotopes induced arthritis and/or uveitis upon immunization in Lewis rats, indicating a role for multiple antigens in the initiation of a certain autoimmune disease.

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Molecular mimicry in systemic lupus erythematosus

Lupus ◽

10.1177/0961203309346653 ◽

2009 ◽

Vol 18 (13) ◽

pp. 1181-1185 ◽

Cited By ~ 33

Author(s):

N. Agmon-Levin ◽

M. Blank ◽

Z. Paz ◽

Y. Shoenfeld

Keyword(s):

Systemic Lupus Erythematosus ◽

Autoimmune Disease ◽

Autoimmune Diseases ◽

Lupus Erythematosus ◽

Molecular Mimicry ◽

Current Evidence ◽

Systemic Autoimmune Disease ◽

Infectious Agents ◽

Systemic Lupus ◽

Pivotal Mechanism

Systemic lupus erythematosus is a multi-systemic autoimmune disease distinguished by the presence of various autoantibodies. Like most autoimmune diseases, systemic lupus erythematosus is believed to be induced by a combination of genetic, immunologic, and environmental factors, mainly infectious agents. Molecular mimicry between an infectious antigen and self-components is implicated as a pivotal mechanism by which autoimmune diseases such as systemic lupus erythematosus are triggered. Here we review the current evidence of molecular mimicry between different infectious agents and systemic lupus erythematosus.

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Interrelation between Rheumatic Autoimmune Disease, Autohemolitic Anemia and Cancer Arising as Epiphenomenon on Paraneoplastic Syndrome

International Journal of Clinical Case Reports and Reviews ◽

10.31579/2690-4861/169 ◽

2021 ◽

Vol 9 (1) ◽

pp. 01-02

Author(s):

Dejan Spasovski ◽

Emilija Sandevska ◽

Svetlana Krsetvska-Balkanov

Keyword(s):

Autoimmune Disease ◽

Hemolytic Anemia ◽

Snake Venom ◽

Paraneoplastic Syndrome ◽

Immunocompetent Cells ◽

Infectious Agents ◽

Different Origin

There are hemolytic anemias of different origin. For instance, these states may be induced by means of some exogenic hemolytic factors: by different organic and unorganic hemolytic toxins (phosphorus, phenylhydrazin, saponins, arsenicum, lead and biotoxins – snake venom, mushroom poisons, mycotoxins, etc.), some medical preparations, radiations, some infectious agents and haevy burns. Besides, in some cases, hemolytic anemias are induced by antibodies and immunocompetent cells against own tissues (autoimmune hemolytic anemia).

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Pathology of Bone Cells in Pigs with Experimental Turbinate Osteoporosis (Atrophic Rhinitis)

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100065560 ◽

1971 ◽

Vol 29 ◽

pp. 304-305

Author(s):

A. W. Fetter ◽

C. C. Capen

Keyword(s):

Mucous Membrane ◽

Bone Cells ◽

Atrophic Rhinitis ◽

Infectious Agents ◽

Metabolic Disturbances ◽

Progressive Reduction ◽

Naturally Occurring ◽

Fundamental Cause ◽

Osteocytic Osteolysis ◽

Uncertain Etiology

Atrophic rhinitis in swine is a disease of uncertain etiology in which infectious agents, hereditary predisposition, and metabolic disturbances have been reported to be of primary etiologic importance. It shares many similarities, both clinically and pathologically, with ozena in man. The disease is characterized by deformity and reduction in volume of the nasal turbinates. The fundamental cause for the localized lesion of bone in the nasal turbinates has not been established. Reduced osteogenesis, increased resorption related to inflammation of the nasal mucous membrane, and excessive resorption due to osteocytic osteolysis stimulated by hyperparathyroidism have been suggested as possible pathogenetic mechanisms.The objectives of this investigation were to evaluate ultrastructurally bone cells in the nasal turbinates of pigs with experimentally induced atrophic rhinitis, and to compare these findings to those in control pigs of the same age and pigs with the naturally occurring disease, in order to define the fundamental lesion responsible for the progressive reduction in volume of the osseous core.

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Laryngeal Manifestations of Autoimmune Diseases

Perspectives of the ASHA Special Interest Groups ◽

10.1044/2020_persp-19-00168 ◽

2020 ◽

Vol 5 (2) ◽

pp. 439-456

Author(s):

Jenny L. Pierce

Keyword(s):

Autoimmune Disease ◽

Autoimmune Diseases ◽

Patient Outcomes ◽

Correct Diagnosis ◽

Upper Airway ◽

Clinical Implications ◽

Laryngeal Function ◽

The Past ◽

Referral Practices ◽

Timely Referral

Purpose This review article provides an overview of autoimmune diseases and their effects on voice and laryngeal function. Method A literature review was conducted in PubMed. Combinations of the following keywords were used: “autoimmune disease and upper airway,” “larynx,” “cough,” “voice,” “dysphonia,” and “dyspnea.” Precedence was given to articles published in the past 10 years due to recent advances in this area and to review articles. Ultimately, 115 articles were included for review. Results Approximately 81 autoimmune diseases exist, with 18 of those highlighted in the literature as having laryngeal involvement. The general and laryngeal manifestations of these 18 are discussed in detail, in addition to the clinical implications for a laryngeal expert. Conclusions Voice, breathing, and cough symptoms may be an indication of underlying autoimmune disease. However, these symptoms are often similar to those in the general population. Appropriate differential diagnosis and timely referral practices maximize patient outcomes. Guidelines are provided to facilitate correct diagnosis when an autoimmune disease is suspected.

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