Disorders of Purine and Pyrimidine Metabolism

2000 ◽  
pp. 354-368 ◽  
Author(s):  
G. van den Berghe ◽  
M.-F. Vincent ◽  
S. Marie
Keyword(s):  
Pyrimidine Metabolism

Features of the spectrum and the concentration of the products of purine and pyrimidine metabolism in thrombolytic therapy in patients with ischemic stroke

2016 ◽  
Vol 18 (2) ◽  
pp. 22-26
Author(s):  
O.V. Lyang ◽  
◽  
V.N. Fedorov ◽  
A.G. Kochetov ◽  
N.A. Shamalov ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Thrombolytic Therapy ◽  
Pyrimidine Metabolism

Pyrimidine metabolism in microorganisms.

1970 ◽  
Vol 34 (3) ◽  
pp. 278-343 ◽  
Author(s):  
G A O'Donovan ◽  
J Neuhard
Keyword(s):  
Pyrimidine Metabolism

scholarly journals Comprehensive Metabolomic Analysis Reveals Dynamic Metabolic Reprogramming in Hep3B Cells with Aflatoxin B1 Exposure

Toxins ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 384
Author(s):  
Shufeng Wang ◽  
Xin Yang ◽  
Feng Liu ◽  
Xinzheng Wang ◽  
Xuemin Zhang ◽  
...  
Keyword(s):  
Aflatoxin B1 ◽  
Drug Targets ◽  
High Sensitivity ◽  
Tca Cycle ◽  
Acid Synthesis ◽  
Metabolic Reprogramming ◽  
Pyrimidine Metabolism ◽  
Rapid Separation ◽  
Hexosamine Pathway ◽  
Hep3b Cells

Hepatitis B virus (HBV) infection and aflatoxin B1 (AFB1) exposure have been recognized as independent risk factors for the occurrence and development of hepatocellular carcinoma (HCC), but their combined impacts and the potential metabolic mechanisms remain poorly characterized. Here, a comprehensive non-targeted metabolomic study was performed following AFB1 exposed to Hep3B cells at two different doses: 16 μM and 32 μM. The metabolites were identified and quantified by an ultra-performance liquid chromatography-mass spectrometry (UPLC-MS)-based strategy. A total of 2679 metabolites were identified, and 392 differential metabolites were quantified among three groups. Pathway analysis indicated that dynamic metabolic reprogramming was induced by AFB1 and various pathways changed significantly, including purine and pyrimidine metabolism, hexosamine pathway and sialylation, fatty acid synthesis and oxidation, glycerophospholipid metabolism, tricarboxylic acid (TCA) cycle, glycolysis, and amino acid metabolism. To the best of our knowledge, the alteration of purine and pyrimidine metabolism and decrease of hexosamine pathways and sialylation with AFB1 exposure have not been reported. The results indicated that our metabolomic strategy is powerful to investigate the metabolome change of any stimulates due to its high sensitivity, high resolution, rapid separation, and good metabolome coverage. Besides, these findings provide an overview of the metabolic mechanisms of the AFB1 combined with HBV and new insight into the toxicological mechanism of AFB1. Thus, targeting these metabolic pathways may be an approach to prevent carcinogen-induced cancer, and these findings may provide potential drug targets for therapeutic intervention.

Enzymatic activities on purine and pyrimidine metabolism in nine mycoplasma species contaminating cell cultures

1980 ◽  
Vol 103 (1) ◽  
pp. 15-22 ◽  
Author(s):  
Michèle hamet ◽  
Christiane Bonissol ◽  
Pierre Cartier
Keyword(s):  
Cell Cultures ◽  
Enzymatic Activities ◽  
Mycoplasma Species ◽  
Pyrimidine Metabolism

Effects of 2-thiouracil and related compounds on pyrimidine metabolism

1968 ◽  
Vol 126 (3) ◽  
pp. 812-820 ◽  
Author(s):  
Raymond H. Lindsay ◽  
Cynthia J. Romine ◽  
Mei Ying Wong
Keyword(s):  
Pyrimidine Metabolism ◽  
Related Compounds

Effects of Allopurinol and Oxonic Acid on Pyrimidine Metabolism in the Pig

1974 ◽  
pp. 637-638 ◽  
Author(s):  
P. J. Hatfield ◽  
H. A. Simmonds ◽  
J. S. Cameron ◽  
A. S. Jones ◽  
A. Cadenhead
Keyword(s):  
Pyrimidine Metabolism ◽  
Oxonic Acid
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