Blood Flow and Regional Sympathetic Activity in the Superior Mesenteric Vascular Bed during Injection and Continuous Infusion of Dopamine

It has been shown that sustained insulin infusion causes an increase in sympathetic vasoconstrictor discharge but, despite this, also causes peripheral vasodilatation. The present study was designed to determine in healthy subjects the effect of ingestion of a carbohydrate meal, with its attendant physiological insulinaemia, on vascular resistance in and sympathetic vasoconstrictor discharge to the same vascular bed, and the relationship between these parameters. Fifteen healthy subjects were studied for 2h following ingestion of a carbohydrate meal. Calf vascular resistance was measured by venous occlusion plethysmography, and muscle sympathetic nerve activity was assessed by peroneal microneurography. Five of the subjects also ingested water on a separate occasion, as a control. Following the carbohydrate meal, the serum insulin concentration increased to 588±72pmol/l. This was associated with a 47% increase in skeletal muscle blood flow (P < 0.001), a 39% fall in vascular resistance (P < 0.001) and a 57% increase in sympathetic activity (P < 0.001). There was a significant correlation between the increase in insulin and the changes in blood flow, vascular resistance and sympathetic activity. In conclusion, we have shown that ingestion of a carbohydrate meal, with its attendant physiological insulinaemia, was associated with overriding skeletal muscle vasodilatation, despite an increase in sympathetic vasoconstrictor discharge to the same vascular bed. These mechanisms may be important in ensuring optimal glucose uptake and maintenance of blood pressure postprandially.

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Sites of autoregulatory escape of blood flow in the mesenteric vascular bed.

The Journal of Physiology ◽

10.1113/jphysiol.1976.sp011451 ◽

1976 ◽

Vol 259 (1) ◽

pp. 1-12 ◽

Cited By ~ 19

Author(s):

C V Greenway ◽

G D Scott ◽

J Zink

Keyword(s):

Blood Flow ◽

Vascular Bed ◽

Autoregulatory Escape ◽

Mesenteric Vascular Bed

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Effects of Dopamine and Other Catecholamines on the Splanchnic Circulation

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y72-088 ◽

1972 ◽

Vol 50 (6) ◽

pp. 594-602 ◽

Cited By ~ 11

Author(s):

Linda L. Shanbour ◽

Don Parker

Keyword(s):

Blood Flow ◽

Hepatic Artery ◽

Mesenteric Artery ◽

Splanchnic Circulation ◽

Blood Flows ◽

Vascular Bed ◽

Competitive Action ◽

Responses To Dopamine ◽

Mesenteric Vascular Bed ◽

Dose Levels

Studies were conducted to evaluate the effects of dopamine (3, 4-dihydroxyphenylethylamine) and other catecholamines on the mesenteric vascular bed in dogs. Mesenteric and hepatic artery blood flows were measured with electromagnetic blood flow transducers. Catecholamines were infused intra-arterially into a branch-of the mesenteric artery. Dopamine consistently decreased mesenteric and hepatic artery blood flows at all dose levels studied (5–100 mg/kg). Phenoxybenzamine (12.5 mg/kg) blocked the effects of norepinephrine (0.05–1.0 μg/kg) and reversed the responses to dopamine in the mesenteric bed to those of pure vasodilation (no transient constriction was observed) but failed to abolish the constrictor action of dopamine on the hepatic artery. Propranolol or haloperidol, when administered with the phenoxybenzamine, did not attenuate the mesenteric responses to dopamine. Haloperidol prevented the hepatic artery vasoconstriction produced by dopamine but did not alter isoproterenol-induced hepatic artery vasodilation. No competitive action was observed between dopamine and norepinephrine or isoproterenol. These results suggest that (1) dopamine produces selective vasodilation of the mesenteric bed which is not blocked by haloperidol, and (2) dopamine has a unique action on the hepatic vascular bed which is blocked by haloperidol.

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Analysis of the Effects of Candesartan in the Mesenteric Vascular Bed of the Cat

Hypertension ◽

10.1161/01.hyp.30.5.1260 ◽

1997 ◽

Vol 30 (5) ◽

pp. 1260-1266 ◽

Cited By ~ 10

Author(s):

Hunter C. Champion ◽

Philip J. Kadowitz

Keyword(s):

Vascular Bed ◽

Mesenteric Vascular Bed

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L-ARG/NO pathway contributes to LPS-induced hyporeactivity in rat mesenteric vascular bed: Effect of no-synthase inhibitors

Pharmacological Research ◽

10.1016/1043-6618(95)86513-6 ◽

1995 ◽

Vol 31 ◽

pp. 63 ◽

Cited By ~ 1

Author(s):

M. Potenza ◽

M. Serio ◽

M. Montagnani ◽

G. Mansi ◽

S. Pece ◽

...

Keyword(s):

No Synthase ◽

Vascular Bed ◽

Mesenteric Vascular Bed

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Losartan prevents mesenteric vascular bed alterations in high-fat diet fed rats

Clínica e Investigación en Arteriosclerosis ◽

10.1016/j.arteri.2020.06.004 ◽

2020 ◽

Author(s):

Hyun J. Lee ◽

Silvana M. Cantú ◽

María Álvarez Primo ◽

Horacio A. Peredo ◽

Adriana S. Donoso ◽

...

Keyword(s):

High Fat Diet ◽

High Fat ◽

Vascular Bed ◽

Mesenteric Vascular Bed

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Analysis of responses to hAmylin, hCGRP, and hADM in isolated resistance arteries from the mesenteric vascular bed of the rat

Peptides ◽

10.1016/s0196-9781(01)00482-x ◽

2001 ◽

Vol 22 (9) ◽

pp. 1427-1434 ◽

Cited By ~ 13

Author(s):

Hunter C. Champion ◽

Robert L. Pierce ◽

Trinity J. Bivalacqua ◽

William A. Murphy ◽

David H. Coy ◽

...

Keyword(s):

Resistance Arteries ◽

Vascular Bed ◽

Mesenteric Vascular Bed

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ANGIOPULMONOGRAPHY WITH NITROGLYCERIN TEST IN THE DIAGNOSIS OF ACUTE INFECTIOUS LUNG DESTRUCTION

Novosti Khirurgii ◽

10.18484/2305-0047.2021.4.412 ◽

2021 ◽

Vol 29 (4) ◽

pp. 412-419

Author(s):

V.I. Petukhov ◽

◽

V.I. Derkach ◽

S.N. Ermashkevich ◽

M.V. Kuntsevich ◽

...

Keyword(s):

Blood Flow ◽

Differential Diagnosis ◽

Test Performance ◽

Blood Circulation ◽

Lung Parenchyma ◽

Inflammatory Infiltration ◽

Affected Area ◽

Vascular Bed ◽

Pulmonary Parenchyma ◽

Flow Through

Objective. To develop a method for additional and differential diagnosis of acute infectious lung destruction (AILD) based on angiopulmonography with the nitroglycerin test. Methods. Angiopulmonography with the nitroglycerin test was used in 10 patients with suppurative diseasesof thelung and pleura for additional and differential diagnosis of AILD The method was used in such situations when chest computed tomography did not allow to determine unambiguously the presence and / or prevalence of necrosis of the lung parenchyma. Results. In 3 patients with the lung abscess, a clear restriction of the decay cavity was registered with the preservation of the main blood flow and weakening of the parenchymal phase of the blood circulation along the periphery of the destructive area. During the nitroglycerin test performance there was no change in the filling of the microvascular bed with contrast along the periphery of the decay cavity, which made it possible to determine the presence of parietal sequesters. According to the results of the study, the lung gangrene was diagnosed in 6 patients. At the same time, two variants of circulatory disorders were noted: the first - with preservation of the blood flow through the main vessels and with the absence of a parenchymal phase in the lesion focus, the second - with the violation of the main blood flow. In the affected area no change in blood flow was observed after the nitroglycerin test performance. Similar results of the study indicated the development of necrosis of the pulmonary parenchyma, which was subsequently confirmed during the operations performed. In the site of inflammatory infiltration of the pulmonary parenchyma with preserved main blood flow, the depletion of the parenchymal phase of blood circulation was determined, but after the nitroglycerin test, a pronounced enrichment of the vascular architecture to the parenchymal phase in the pneumonia affecting part of the lung was noted. Conclusion. It has been established that AILD is characterized by irreversible changes in the vascular bed of the lung parenchyma in the lesion focus. Angiopulmonography with the nitroglycerin test is considered to be an additional highly informative method improving the early and differential diagnosis of AILD in difficult clinical situations. What this paper adds It has been found out that during angiopulmonography the areas of pulmonary necrosis are characterized by the absence of a vascular pattern with or without disturbance of the blood flow through the segmental arteries. At the same time, in contrast to the foci of pneumonia, the nitroglycerin test is not accompanied by an evaluation of the filling of the pulmonary vascular bed in the affected area, i.e. blood supply disorders are irreversible. Thus, based on an assessment of the nature and reversibility of the blood flow disturbances in the affected lung, it is possible to carry out differential diagnosis of the early stages of acute infectious lung destruction (AILD) and pneumonia.

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Dynamics of the speed of blood flow in the arteries of the bone regenerate of the limbs and in the brain arteries during functional tests and changes in the treatment mode

Regional blood circulation and microcirculation ◽

10.24884/1682-6655-2018-17-4-51-56 ◽

2019 ◽

Vol 17 (4) ◽

pp. 51-56 ◽

Cited By ~ 1

Author(s):

V. A. Schurov

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Flow Velocity ◽

Treatment Regimen ◽

Blood Flow Velocity ◽

Outpatient Treatment ◽

Lower Leg ◽

Temporary Increase ◽

Functional Tests ◽

Vascular Bed

The results of a comparative study of the linear velocity of blood flow in the arteries of the bone regenerate in patients with fractures of the leg and shoulder bones and in the process of Ilizarov treatment are analyzed. Studies were conducted at rest and when performing a number of functional tests (orthostatic, muscular and with a dosed axial load on the limb). The effect of stress on the state of regional and cerebral blood flow in the conditions of inpatient treatment and after the transfer of patients to the outpatient treatment regimen was assessed.Material and methods. 41 adult patients with a closed diaphyseal fracture of the humerus and 57 patients with a fracture of the tibia bones during Ilizarov treatment were examined. The blood flow in the regenerate and along the middle cerebral arteries was determined by the method of ultrasonic doppler sonography.Results. With an increase in the functional load on the limb in patients with fractures of the humerus and tibial bones, respectively, up to 10 and 30 kgf, a temporary increase in the blood flow velocity in the arteries of the bone regenerate was observed. Large values of the load on the lower leg, accompanied by the acceleration of blood flow, indicate a better protection of the vascular bed of the tibial regenerate. The magnitude of the decrease in blood flow velocity in the regeneration of the lower leg arising from the behavior of an orthostatic test in the course of treating patients increased from 21 to 37 %, and indicated an increase in the reactivity of the vascular bed. In patients with injuries of the shoulder and lower leg, the transfer to the outpatient treatment regimen was accompanied by a statistically significant (p≤0.001) increase in the duration of the fixation period, respectively, to 82±3 and 94±7 days, a decrease in the increased blood flow velocity in the middle cerebral artery on the contralateral side by 43 % and 57 % and an increase in the magnitude of changes in cerebral blood flow rate during functional muscle test by 50 and 67 %.

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