scholarly journals Hepatic nuclear factor 1-β

2019 ◽  
pp. 1090-1090
Author(s):  
K. J. Lackner ◽  
D. Peetz
Keyword(s):  
Nuclear Factor ◽  
Hepatic Nuclear Factor 1 ◽  
Nuclear Factor 1

scholarly journals Neurogenin3 and Hepatic Nuclear Factor 1 Cooperate in Activating Pancreatic Expression of Pax4

2003 ◽  
Vol 278 (40) ◽  
pp. 38254-38259 ◽  
Author(s):  
Stuart B. Smith ◽  
Rosa Gasa ◽  
Hirotaka Watada ◽  
Juehu Wang ◽  
Steven C. Griffen ◽  
...  
Keyword(s):  
Nuclear Factor ◽  
Hepatic Nuclear Factor 1 ◽  
Nuclear Factor 1

scholarly journals Identifying Hepatic Nuclear Factor 1  Mutations in Children and Young Adults With a Clinical Diagnosis of Type 1 Diabetes

Diabetes Care ◽  
2003 ◽  
Vol 26 (2) ◽  
pp. 333-337 ◽  
Author(s):  
A. P. Lambert ◽  
S. Ellard ◽  
L. I.S. Allen ◽  
I. W. Gallen ◽  
K. M. Gillespie ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Young Adults ◽  
Clinical Diagnosis ◽  
Nuclear Factor ◽  
Children And Young Adults ◽  
Hepatic Nuclear Factor 1 ◽  
Nuclear Factor 1

scholarly journals Decreased expression levels of rat liver glutathione S-transferase A2 and albumin during the acute phase response are mediated by HNF1 (hepatic nuclear factor 1) and IL6DEX-NP

2004 ◽  
Vol 377 (3) ◽  
pp. 763-768 ◽  
Author(s):  
Richard WHALEN ◽  
Susan H. VOSS ◽  
Thomas D. BOYER
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Rat Hepatocytes ◽  
Phase Response ◽  
Negative Regulator ◽  
Nuclear Factor ◽  
Hepatic Nuclear Factor 1 ◽  
Nuclear Factor 1

The acute phase response is characterized by positive and negative regulation of many liver proteins including GSTs (glutathione S-transferases) and albumin. The expression of albumin and some GSTs are dependent on HNF1 (hepatic nuclear factor 1). Interleukin 6 plus dexamethasone induce a nuclear protein (IL6DEX-NP) in rat hepatocytes in vitro that binds to a promoter element adjacent to the HNF1 site of rGSTA2 and decreases its expression. We determined how HNF1 and IL6DEX-NP regulate rGSTA2 and albumin expression in rats during the acute phase response after LPS (lipopolysaccharide) treatment. Expression of rGSTA2 and albumin mRNA decreased 3 h after LPS treatment and remained low for 48 h. Transcription rates showed a similar pattern but albumin transcription was less affected. HNF1 and IL6DEX-NP binding to the rGSTA2 promoter was present in control livers but was absent at 3 and 6 h after LPS. By 12 h, HNF1 and IL6DEX-NP binding to the rGSTA2 promoter reappeared and increased to above normal at 48 h. The patterns of HNF1 and IL6DEX-NP binding to the albumin promoter were similar. Affinity of IL6DEX-NP for the albumin promoter was less than that for the rGSTA2 promoter and changes in the transcription rates were consistent with the difference. Early decreases in rGSTA2 and albumin during the acute phase response are due to decreased binding of HNF1. Later persistent decreases in transcriptional rate of rGSTA2 and to a lesser extent albumin are due to increased IL6DEX-NP binding. IL6DEX-NP appears to be an important negative regulator of gene expression in vitro and in vivo.

Cloning of human hepatic nuclear factor 1 (HNF1) and chromosomal localization of its gene in man and mouse

Genomics ◽  
1990 ◽  
Vol 8 (1) ◽  
pp. 155-164 ◽  
Author(s):  
Ingolf Bach ◽  
Zoya Galcheva-Gargova ◽  
Marie-Geneviève Mattei ◽  
Dominique Simon-Chazottes ◽  
Jean-Louis Guénet ◽  
...  
Keyword(s):  
Chromosomal Localization ◽  
Nuclear Factor ◽  
Its Gene ◽  
Hepatic Nuclear Factor 1 ◽  
Nuclear Factor 1

Hepatic nuclear factor 1 (HNF1) shows a wider distribution than products of its known target genes in developing mouse

Development ◽  
1991 ◽  
Vol 113 (2) ◽  
pp. 589-599 ◽  
Author(s):  
M. Blumenfeld ◽  
M. Maury ◽  
T. Chouard ◽  
M. Yaniv ◽  
H. Condamine
Keyword(s):  
Target Genes ◽  
Hepatoma Cell ◽  
Nuclear Factor ◽  
Visceral Endoderm ◽  
Hepatoma Cell Lines ◽  
Highly Active ◽  
Adult Kidney ◽  
Hepatic Nuclear Factor 1 ◽  
Nuclear Factor 1

Hepatic nuclear factor 1 (HNF1) is a highly diverged homeoprotein that is crucial for transcription of many liver-specific genes including albumin. In particular, a minimal promoter, consisting of an HNF1-binding-site and a TATA box, is highly active only in hepatoma cell lines. The expression of the HNF1 and albumin genes has been examined in mouse embryos by in situ hybridization. At 10.5 days of gestation, the HNF1 mRNA was detected in both the hepatic primordia and visceral endoderm of the yolk sac whereas the albumin transcript was present only in the nascent liver. At later stages of development, HNF1 was detected in liver, in the epithelial cells of most of the digestive tract and in the cortex of the kidney, whereas albumin was again found only in the liver. The presence of HNF1 protein in adult kidney was demonstrated by immunodetection in gel-retardation assays and western blot analysis. These experiments show that, even though the HNF1 homeo-protein is essential for expression of many liver-specific genes, it cannot, by itself, force high expression levels of these genes, in non-hepatic tissues.

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