Neurotrophic factors and CNS regeneration

1998 ◽  
pp. 129-155 ◽  
Author(s):  
T. Hagg ◽  
M. Oudega
Keyword(s):  
Neurotrophic Factors ◽  
Cns Regeneration

scholarly journals Olfactory Ensheathing Glia: Drivers of Axonal Regeneration in the Central Nervous System?

2002 ◽  
Vol 2 (1) ◽  
pp. 37-43 ◽  
Author(s):  
M. Teresa Moreno-Flores ◽  
Javier Díaz-Nido ◽  
Francisco Wandosell ◽  
Jesús Avila
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adhesion Molecules ◽  
Neurotrophic Factors ◽  
Axonal Regeneration ◽  
Cns Regeneration ◽  
The Central Nervous System ◽  
Large Heterogeneity ◽  
Olfactory Ensheathing Glia ◽  
Glial Scarring

Olfactory ensheathing glia (OEG) accompany olfactory growing axons in their entry to the adult mammalian central nervous system (CNS). Due to this special characteristic, considerable attention has been focused on the possibility of using OEG for CNS regeneration. OEG present a large heterogeneity in culture with respect to their cellular morphology and expressed molecules. The specific characteristics of OEG responsible for their regenerative properties have to be defined. These properties probably result from the combination of several factors: molecular composition of the membrane (expressing adhesion molecules as PSA-NCAM, L1 and/or others) combined with their ability to reduce glial scarring and to accompany new growing axons into the host CNS. Their capacity to produce some neurotrophic factors might also account for their ability to produce CNS regeneration.

scholarly journals Regenerative Potential of Carbon Monoxide in Adult Neural Circuits of the Central Nervous System

2020 ◽  
Vol 21 (7) ◽  
pp. 2273
Author(s):  
Eunyoung Jung ◽  
Seong-Ho Koh ◽  
Myeongjong Yoo ◽  
Yoon Kyung Choi
Keyword(s):  
Central Nervous System ◽  
Carbon Monoxide ◽  
Nervous System ◽  
Neurotrophic Factors ◽  
Neural Circuits ◽  
Cns Injury ◽  
Cns Regeneration ◽  
The Central Nervous System ◽  
Endogenous Neural Stem Cells

Regeneration of adult neural circuits after an injury is limited in the central nervous system (CNS). Heme oxygenase (HO) is an enzyme that produces HO metabolites, such as carbon monoxide (CO), biliverdin and iron by heme degradation. CO may act as a biological signal transduction effector in CNS regeneration by stimulating neuronal intrinsic and extrinsic mechanisms as well as mitochondrial biogenesis. CO may give directions by which the injured neurovascular system switches into regeneration mode by stimulating endogenous neural stem cells and endothelial cells to produce neurons and vessels capable of replacing injured neurons and vessels in the CNS. The present review discusses the regenerative potential of CO in acute and chronic neuroinflammatory diseases of the CNS, such as stroke, traumatic brain injury, multiple sclerosis and Alzheimer’s disease and the role of signaling pathways and neurotrophic factors. CO-mediated facilitation of cellular communications may boost regeneration, consequently forming functional adult neural circuits in CNS injury.

Modulation of rat visceral pain by brain-derived neurotrophic factors (BDNF)

2010 ◽  
Vol 34 (8) ◽  
pp. S22-S22
Author(s):  
Rong Wei ◽  
Ying Gao ◽  
Xiaoxue Ding ◽  
Ziqi Yue ◽  
Sha Wu ◽  
...  
Keyword(s):  
Neurotrophic Factors ◽  
Visceral Pain

Improvement of somatopsychic and cognitive abilities in a post-stroke patient treated with neurotrophic factors

Psihiatru ro ◽  
2020 ◽  
Vol 4 (63) ◽  
pp. 30
Author(s):  
Gabriela Marian ◽  
Brânduşa Ecaterina Focşeneanu ◽  
George Stercu ◽  
Andrei-Cristian Bondar ◽  
Claudiu Pavel ◽  
...  
Keyword(s):  
Stroke Patient ◽  
Neurotrophic Factors ◽  
Cognitive Abilities ◽  
Post Stroke

Expression of mRNA of Neurotrophic Factors and their Receptors are Significantly Altered After Subchronic Ketamine Treatment

2008 ◽  
Vol 4 (3) ◽  
pp. 256-263 ◽  
Author(s):  
Axel Becker ◽  
Gisela Grecksch ◽  
Herbert Schwegler ◽  
Thomas Roskoden
Keyword(s):  
Neurotrophic Factors

Hippocampal Neurogenesis, Neurotrophic Factors and Depression: Possible Therapeutic Targets?

2015 ◽  
Vol 13 (10) ◽  
pp. 1708-1721 ◽  
Author(s):  
Gianluca Serafini ◽  
Shawn Hayley ◽  
Maurizio Pompili ◽  
Yogesh Dwivedi ◽  
Goutam Brahmachari ◽  
...  
Keyword(s):  
Neurotrophic Factors ◽  
Therapeutic Targets ◽  
Hippocampal Neurogenesis
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