A Within-Host Model of Dengue Viral Infection Dynamics

2016 ◽  
pp. 165-176
Author(s):  
Arti Mishra
Keyword(s):  
Viral Infection ◽  
Infection Dynamics

scholarly journals More than efficacy revealed by single-cell analysis of antiviral therapeutics

2019 ◽  
Vol 5 (10) ◽  
pp. eaax4761 ◽  
Author(s):  
Wu Liu ◽  
Mehmet U. Caglar ◽  
Zhangming Mao ◽  
Andrew Woodman ◽  
Jamie J. Arnold ◽  
...  
Keyword(s):  
Viral Infection ◽  
Single Cell ◽  
Single Cell Analysis ◽  
Principal Component ◽  
Cell Analysis ◽  
Infection Cycle ◽  
Reporter Protein ◽  
Fluorescent Reporter ◽  
Infection Dynamics ◽  
Infected Cells

Because many aspects of viral infection dynamics and inhibition are governed by stochastic processes, single-cell analysis should provide more information than approaches using population averaging. We have developed a microfluidic device composed of ~6000 wells, with each well containing a microstructure to capture single, infected cells replicating an enterovirus expressing a fluorescent reporter protein. We have used this system to characterize enterovirus inhibitors with distinct mechanisms of action. Single-cell analysis reveals that each class of inhibitor interferes with the viral infection cycle in a manner that can be distinguished by principal component analysis. Single-cell analysis of antiviral candidates not only reveals efficacy but also facilitates clustering of drugs with the same mechanism of action and provides some indication of the ease with which resistance will develop.

scholarly journals Quantification of viral infection dynamics in animal experiments

2013 ◽  
Vol 4 ◽  
Author(s):  
Shingo Iwami ◽  
Yoshiki Koizumi ◽  
Hiroki Ikeda ◽  
Yusuke Kakizoe
Keyword(s):  
Viral Infection ◽  
Animal Experiments ◽  
Infection Dynamics

scholarly journals A Simulation Framework to Investigate in vitro Viral Infection Dynamics

2011 ◽  
Vol 4 ◽  
pp. 1798-1807
Author(s):  
Armand Bankhead ◽  
Emiliano Mancini ◽  
Amy C. Sims ◽  
Ralph S. Baric ◽  
Shannon McWeeney ◽  
...  
Keyword(s):  
Viral Infection ◽  
Simulation Framework ◽  
Infection Dynamics

Stability and Hopf Bifurcation of a Delayed Viral Infection Dynamics Model with Immune Impairment

2021 ◽  
Vol 31 (08) ◽  
pp. 2150141
Author(s):  
Xiaomin Zhang ◽  
Rui Xu ◽  
Chenwei Song
Keyword(s):  
Hopf Bifurcation ◽  
Time Delay ◽  
Viral Infection ◽  
Local Stability ◽  
Sufficient Conditions ◽  
Dynamics Model ◽  
Infection Dynamics ◽  
Immune Impairment ◽  
Theoretical Results ◽  
Iteration Technique

In this paper, we consider a viral infection dynamics model with immune impairment and time delay in immune expansion. By calculation, it is shown that the model has three equilibria: infection-free equilibrium, immunity-inactivated infection equilibrium, and immunity-activated infection equilibrium. By analyzing the distributions of roots of corresponding characteristic equations, the local stability of the infection-free equilibrium and the immunity-inactivated infection equilibrium is established. Furthermore, we discuss the existence of Hopf bifurcation at the immunity-activated infection equilibrium. Sufficient conditions are obtained for the global asymptotic stability of each feasible equilibria of the model by using LaSalle’s invariance principle and iteration technique, respectively. Numerical simulations are carried out to illustrate the main theoretical results.

scholarly journals A simulation framework to investigate in vitro viral infection dynamics

2013 ◽  
Vol 4 (3) ◽  
pp. 127-134 ◽  
Author(s):  
Armand Bankhead ◽  
Emiliano Mancini ◽  
Amy C. Sims ◽  
Ralph S. Baric ◽  
Shannon McWeeney ◽  
...  
Keyword(s):  
Viral Infection ◽  
Simulation Framework ◽  
Infection Dynamics
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