The aim: study of the effectiveness of the combined treatment of cysts in women after cosmetic breast endoprosthesis with the help of ozone therapy and drug Mastodinon. Material and methods. For 1.5 years with dynamic control after 6-12 months. clinical-x-ray-sonographic examination of the mammary glands of 21 women aged 34 to 42 years with different variants of mastopathy and cysts after cosmetic endoprosthesis was carried out. For therapeutic purposes, a fine needle aspiration biopsy of breast cysts was performed under ultrasound control, followed by the introduction of an ozone-oxygen mixture into the cavity at a concentration of 40-80 mcg/ml, in parallel, a herbal preparation Mastodinon was prescribed for 1 tab. X 2 times a day for 3 months. Results. The examined patients complained of pain, a feeling of swelling, the presence of insomnia, periodic feeling of heaviness and swelling, a sense of fear, apprehension and uncertainty associated with the surgical intervention to install implants. Clinical-x-ray-sonographic examination in all patients revealed fibrocystic mastopathy of varying severity with cysts from 0.5 to 2 cm. Control studies every 6 months during the year showed positive dynamics of combined treatment of breast cysts after ozone therapy and the use of Mastodinon as a stable therapeutic effect in 91% of cases. In 20 of the 21 cases, the cysts did not recur, the clinical symptoms of mastalgia did not bother. Conclusion. Combined conservative treatment of breast cysts after cosmetic endoprosthesis with sequential introduction into the emptied cavity of ozone-oxygen mixture at a concentration of at least 70-80 mcg/ml with the appointment of the drug Mastodinon for 3 months. Stably reduces clinical manifestations of fibrocystic mastitis and eliminates recurrence of cysts in 91% of cases, improves the quality of life of patients.