On-Chip Concentration of Liquid Samples Using an Air-Liquid Two-Phase Flow

Author(s):  
Manabu Tokeshi ◽  
Kazuteru Kanda ◽  
Akihide Hibara ◽  
Takehiko Kitamori
2014 ◽  
Vol 24 (1) ◽  
pp. 77-83 ◽  
Author(s):  
Zhaochu Yang ◽  
Tao Dong ◽  
Einar Halvorsen

Author(s):  
Christian Weinmu¨ller ◽  
Nicole R. Bieri ◽  
Dimos Poulikakos

The area of microfluidics has experienced a tremendous increase in research activities in recent years with a wide range of applications, such as micro heat exchangers and energy conversion devices, microreactors, lab-on-chip devices, micro total chemical analysis systems (μTAS) etc. The occurrence of two phase flow can lead to several mechanisms enhancing or extending the performance of single phase microfluidic devices [1]. On the other hand, in a micro fuel cell the second, non-immiscible phase is considered to hamper the performance of the fuel cell [2]. Regardless of its effect, two phase flows in microfluidics deserve special research attention.


Author(s):  
Colin King ◽  
Edmond Walsh ◽  
Ronan Grimes

The use of two phase flow in lab-on-chip devices, where chemical and biological reagents are enclosed within plugs separated from each other by an immiscible fluid, offers significant advantages for the development of devices with high throughput of individual heterogeneous samples. Lab-on-chip devices designed to perform the polymerase chain reaction (PCR) are a prime example of such developments. The internal circulation within the plugs used to transport the reagents affects the efficiency of the chemical reaction within the plug, due to the degree of mixing induced on the reagents by the flow regime. It has been hypothesised in the literature that all plug flows produce internal circulation. This work demonstrates experimentally that this is false, and seeks to elucidate the parameters influencing the internal circulation of plugs. The particle image velocimetry (PIV) technique offers a powerful non-intrusive tool to study such flow fields. This paper presents micro-PIV experiments carried out to study the internal circulation of aqueous plugs in two phase flow within 762μm internal diameter FEP Teflon tubing with FC-40 as the segmenting fluid. Experiments have been performed and the results are presented for plugs ranging in length from 1mm to 13mm with an average fluid velocity ranging from 0.3mm/s to 50mm/s. The results demonstrate that circulation within the plugs is not always present and requires design considerations to benefit from this phenomenon.


2016 ◽  
Vol 25 (1) ◽  
pp. 197-206 ◽  
Author(s):  
Zhaochu Yang ◽  
Tao Dong ◽  
Atle Jensen ◽  
Einar Halvorsen

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