Quadruple therapy should be second-line treatment for Helicobacter pylori infection

2000 ◽  
pp. 631-635 ◽  
Author(s):  
A. Axon
Helicobacter ◽  
2007 ◽  
Vol 12 (6) ◽  
pp. 623-628 ◽  
Author(s):  
Jung Mook Kang ◽  
Nayoung Kim ◽  
Dong Ho Lee ◽  
Young Soo Park ◽  
Yu Rim Kim ◽  
...  

2002 ◽  
Vol 34 ◽  
pp. A21
Author(s):  
F. Iacopini ◽  
O.A. Paoluzi ◽  
A. Consolazio ◽  
G. Occhigrossi ◽  
R. Pica ◽  
...  

2022 ◽  
Vol 12 (1) ◽  
pp. 56
Author(s):  
Jeemyoung Kim ◽  
Eun Jeong Gong ◽  
Myeongsook Seo ◽  
Hyun Il Seo ◽  
Jong Kyu Park ◽  
...  

Bismuth quadruple therapy (BQT) is an effective treatment for Helicobacter pylori infection. However, frequent dosing schedules of BQT regimen often compromise drug adherence and may affect treatment outcomes. This retrospective study aimed to investigate the efficacy of twice-daily BQT compared to that of four times a day therapy. From August 2018 to November 2020, adult patients who failed first-line standard triple therapy and underwent BQT were eligible. Patients were categorized into two groups according to dosing schedule: (i) the BQT group (n = 213) who received standard BQT administered four times a day; and (ii) the BQTb group (n = 141) who received proton pump inhibitor, bismuth 600 mg, metronidazole 500 mg, and tetracycline 1 g twice a day. The eradication rate did not differ between the BQT (92.5%) and the BQTb groups (90.1%) (p = 0.441). Adherence and adverse event rate were similar between the two groups. Multivariate analysis showed that current smoking was associated with eradication failure; however, dosing frequency was not associated with the efficacy of eradication therapy. This study suggested that twice a day BQT is as effective as four times a day therapy for second-line treatment of H. pylori infection.


2012 ◽  
Vol 142 (5) ◽  
pp. S-483-S-484 ◽  
Author(s):  
Kwang Hyun Chung ◽  
Dong Ho Lee ◽  
Nayoung Kim ◽  
Cheol Min Shin ◽  
Jin Hyeok Hwang ◽  
...  

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