Regulation of Autophagy in Cardiovascular Diseases by Natural Products

2020 ◽  
pp. 731-736
Author(s):  
Simeng Gu ◽  
Xuejun Li
Keyword(s):  
Natural Products ◽  
Cardiovascular Diseases

Natural products targeting ER stress pathway for the treatment of cardiovascular diseases

2018 ◽  
Vol 132 ◽  
pp. 119-129 ◽  
Author(s):  
Ker Woon Choy ◽  
Dharmani Murugan ◽  
Mohd Rais Mustafa
Keyword(s):  
Natural Products ◽  
Cardiovascular Diseases ◽  
Er Stress ◽  
Stress Pathway

System-level multi-target drug discovery from natural products with applications to cardiovascular diseases

2014 ◽  
Vol 18 (3) ◽  
pp. 621-635 ◽  
Author(s):  
Chunli Zheng ◽  
Jinan Wang ◽  
Jianling Liu ◽  
Mengjie Pei ◽  
Chao Huang ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Cardiovascular Diseases ◽  
System Level ◽  
Target Drug

Cardiovascular Diseases and Natural Products

2019 ◽  
Vol 20 (10) ◽  
pp. 962-963 ◽  
Author(s):  
Zhu Chen ◽  
Zhiwei Liu ◽  
Yu Peng ◽  
Li Leng ◽  
Li Du ◽  
...  
Keyword(s):  
Natural Products ◽  
Cardiovascular Diseases

Natural Products for the Management of Cardiovascular Diseases

2020 ◽  
pp. 151-202
Author(s):  
Mohamed A. Salem ◽  
Mahitab H. El Bishbishy ◽  
Ahmed Zayed ◽  
Amr A. Mahrous ◽  
Maha M. Salama ◽  
...  
Keyword(s):  
Natural Products ◽  
Cardiovascular Diseases

Natural Products and Cardiovascular Diseases

2021 ◽  
Vol 14 (6) ◽  
pp. 923-924
Author(s):  
Kunming Tian ◽  
Suowen Xu
Keyword(s):  
Natural Products ◽  
Cardiovascular Diseases

scholarly journals Antioxidant Food Components for the Prevention and Treatment of Cardiovascular Diseases: Effects, Mechanisms, and Clinical Studies

2021 ◽  
Vol 2021 ◽  
pp. 1-17
Author(s):  
Dan-Dan Zhou ◽  
Min Luo ◽  
Ao Shang ◽  
Qian-Qian Mao ◽  
Bang-Yan Li ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Natural Products ◽  
Cardiovascular Diseases ◽  
Bioactive Compounds ◽  
Clinical Studies ◽  
Experimental Studies ◽  
Epigallocatechin Gallate ◽  
Epidemiological Studies ◽  
Beneficial Effects ◽  
High Prevalence

Cardiovascular diseases (CVDs) have gained increasing attention because of their high prevalence and mortality worldwide. Epidemiological studies revealed that intake of fruits, vegetables, nuts, and cereals could reduce the risk of CVDs, and their antioxidants are considered as the main contributors. Moreover, experimental studies showed that some antioxidant natural products and their bioactive compounds exerted beneficial effects on the cardiovascular system, such as polyphenols, polysaccharides, anthocyanins, epigallocatechin gallate, quercetin, rutin, and puerarin. The mechanisms of action mainly included reducing blood pressure, improving lipid profile, ameliorating oxidative stress, mitigating inflammation, and regulating gut microbiota. Furthermore, clinical trials confirmed the cardiovascular-protective effect of some antioxidant natural products, such as soursop, beetroot, garlic, almond, and green tea. In this review, we summarized the effects of some antioxidant natural products and their bioactive compounds on CVDs based on the epidemiological, experimental, and clinical studies, with special attention paid to the relevant mechanisms and clinical trials.

scholarly journals Natural Products in Drug Discovery: Approaches and Development

2021 ◽  
pp. 93-110
Author(s):  
Pious Soris Tresina ◽  
Murugeswaran Santhiya Selvam ◽  
Authinarayanan Rajesh ◽  
Asirvatham Doss ◽  
Veerabahu Ramasamy Mohan
Keyword(s):  
Multiple Sclerosis ◽  
Natural Products ◽  
Drug Discovery ◽  
Cardiovascular Diseases ◽  
Pharmaceutical Industry ◽  
Natural Product ◽  
Lead Structure ◽  
Antiinflammatory Agents ◽  
Plant Sources ◽  
Molecular Biological Techniques

Historically, natural products (NP’s) have played a significant role in drug discovery, not only in cancer and infectious diseases, but also in other therapeutic  areas including cardiovascular diseases and multiple sclerosis. Profit and loss, Partnerships and averages, natural products also present certain challenges for drug discovery, such as technical obstacles to screening, isolation, characterization and optimization, which added to decline in their search by the pharmaceutical industry from the 1990s onwards. In recent days the applications of molecular biological techniques have increased the availability of novel compounds that can be conveniently produced in bacteria or yeast or plant sources. In addition to this, combinational chemistry approaches are being based on natural product scaffolds to create screening libraries that closely resemble drug-like compounds. Employing these technologies gives us a chance to execute research in screening new molecules by means of a software and data base to ascertain natural products as a major source for drug discovery. It lastly directs to lead structure discovery. This review discusses plant based natural product drug discovery and how innovative technologies play a role in next generation drug discovery and highlights from the published literature on plants as sources of antiinflammatory agents.   GRAPHICAL ABSTRACT

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