Predicting the Occurrence of Major Adverse Cardiac Events in Patients with Acute Coronary Syndrome Using Synthetic Minority Oversampling Technique and Machine Learning Approach

Author(s):  
Huilin Zheng ◽  
Batireedui Baterdene ◽  
Jong Yun Lee
2020 ◽  
Vol 14 (2) ◽  
pp. 87-95
Author(s):  
Wei Wang ◽  
Tai Li ◽  
Lei Gao ◽  
Yang Li ◽  
Ying Sun ◽  
...  

Aim: This study aimed to investigate the correlation between the expression of circulating miR-208b and miR-499 and acute coronary syndrome (ACS) patients. Materials & methods: A total of 160 consecutive patients with ACS and 48 healthy control subjects were enrolled for primary analysis. The ACS patients (n = 160) were followed up for 6 months for further analysis regarding major adverse cardiac events. Results: Area under the curve values of miR-208b and miR-499 for predicting ACS were 0.910 and 0.851 (p < 0.001, respectively). Cox proportional hazards regression analysis revealed that miR-208b but not miR-499 was an independent predictor of major adverse cardiac events. Conclusion: Circulating miR-208b and miR-499 could be considered as diagnostic or prognostic biomarkers for patients with ACS.


2020 ◽  
Vol 16 (4) ◽  
pp. 217-226
Author(s):  
Dominique N van Dongen ◽  
Rudolf T Tolsma ◽  
Marion J Fokkert ◽  
Erik A Badings ◽  
Aize van der Sluis ◽  
...  

Background: It is not yet investigated whether referral decisions based on prehospital risk stratification of non-ST-elevation Acute Coronary Syndrome (NSTE-ACS) by the complete History, ECG, Age, Risk factors and initial Troponin (HEART) score are feasible and safe. Hypothesis: Implementation of referral decisions based on the prehospital acquired HEART score in patients with suspected NSTE-ACS is feasible and not inferior to routine management in the occurrence of major adverse cardiac events within 45 days. Study design & methods: FamouS Triage 3 is a feasibility study with a before–after sequential design. The aim is to assess whether prehospital HEART-score management including point-of-care troponin measurement is feasible and noninferior to routine management. Primary end point is the occurrence of major adverse cardiac events within 45 days. Conclusion: If referral decisions based on prehospital acquired risk stratification are feasible and noninferior this can become the new prehospital management in suspected NSTE-ACS.


2010 ◽  
Vol 67 (5) ◽  
pp. 480 ◽  
Author(s):  
Karina W. Davidson ◽  
Matthew M. Burg ◽  
Ian M. Kronish ◽  
Daichi Shimbo ◽  
Lucia Dettenborn ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document