Unaltered 5-HT- and desipramine-sensitive [3H]imipramine binding and [3H]5-HT uptake in rat brain after chronic imipramine and norzimeldine treatment

1988 ◽  
Vol 94 (2) ◽  
Author(s):  
Jan Marcusson ◽  
IngerT. B�ckstr�m ◽  
SvanteB. Ross
Keyword(s):  
Rat Brain ◽  
Imipramine Binding ◽  
5 Ht Uptake ◽  
Chronic Imipramine

Neurochemical and Pharmacological Properties of Tianeptine, A Novel Antidepressant

1992 ◽  
Vol 160 (S15) ◽  
pp. 56-60 ◽  
Author(s):  
C. Labrid ◽  
E. Mocaër ◽  
A. Kamoun
Keyword(s):  
Rat Brain ◽  
Ex Vivo ◽  
Animal Experiments ◽  
Pyramidal Cells ◽  
Human Platelets ◽  
Clinical Findings ◽  
Tricyclic Antidepressant ◽  
Laboratory Animals ◽  
5 Ht Uptake

Tianeptine is a tricyclic antidepressant with an unusual chemical structure (a long lateral chain grafted on to a substituted dibenzothiazepin nucleus), and with biochemical and animal-behavioural properties which are strikingly different from those of classical tricyclics. Unlike the latter, which decrease serotonin (5-HT) uptake, acute and chronic tianeptine treatment enhances 5-HT uptake in rat brain and in rat and human platelets ex vivo. In vivo, tianeptine potentiates the depletion of rat brain 5-HT by 4-methyl-alpha-ethyl metatyramine and increases rat hippocampal 5-HIAA; 5-HT uptake inhibitors (e.g. fluoxetine) have opposite effects. On iontophoretic injection into CA1 pyramidal cells, tianeptine shortens the period of neuronal hypoactivity caused by GABA or 5-HT, whereas other tricyclics prolong it, and it enhances attention, learning, and memory in laboratory animals, while classical tricyclics have opposite effects. However, the relationships between these effects of tianeptine in animal experiments and their relevance to clinical findings remain to be determined.

Changes in platelet 3H-imipramine binding with chronic imipramine treatment are not state-dependent

1989 ◽  
Vol 26 (5) ◽  
pp. 478-488 ◽  
Author(s):  
Edward M DeMet ◽  
Robert H. Gerner ◽  
Kate M Bell ◽  
Curtis D Kauffmann ◽  
Aleksandra Chicz-DeMet ◽  
...  
Keyword(s):  
State Dependent ◽  
Imipramine Binding ◽  
Chronic Imipramine
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