Merkel cell (small cell) carcinoma of the skin: Immunohistochemical and ultrastructural demonstration of distinctive perinuclear cytokeratin aggregates and a possible association with B cell neoplasms

1986 ◽  
Vol 18 (5) ◽  
pp. 239-244 ◽  
Author(s):  
Francis P. Kuhajda ◽  
Jean L. Olson ◽  
Risa B. Mann
Keyword(s):  
B Cell ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Merkel Cell

SMALL CELL CARCINOMA OF THE SKIN “NON-MERKEL CELL TYPE”

1985 ◽  
Vol 35 (4) ◽  
pp. 1029-1036
Author(s):  
Kenji Matsuo ◽  
Akira Sakamoto ◽  
Kioko Kawai ◽  
HIDEO Tschiyama ◽  
Akimi Miyata
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Merkel Cell ◽  
Cell Type

Immunostaining for Thyroid Transcription Factor 1 and Cytokeratin 20 Aids the Distinction of Small Cell Carcinoma From Merkel Cell Carcinoma, But Not Pulmonary From Extrapulmonary Small Cell Carcinomas

2001 ◽  
Vol 125 (2) ◽  
pp. 228-231 ◽  
Author(s):  
W. Cheuk ◽  
M. Y. Kwan ◽  
Saul Suster ◽  
John K. C. Chan
Keyword(s):  
Transcription Factor ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Small Cell ◽  
Cytokeratin 20 ◽  
Merkel Cell ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Transcription Factor 1

Abstract Objective.—To study the expression of thyroid transcription factor 1 (TTF-1) and cytokeratin 20 (CK20) in pulmonary small cell carcinomas, extrapulmonary small cell carcinomas, and Merkel cell carcinomas, and thereby determine whether these markers are helpful in distinguishing these 3 groups of small cell neuroendocrine carcinomas. Materials and Methods.—Immunostaining for TTF-1 and CK20 was performed in 102 cases of small cell carcinoma (pulmonary, 52; extrapulmonary, 50) and 23 cases of Merkel cell carcinoma. The results for the 3 groups were compared. Results.—Thyroid transcription factor 1 was expressed in 82.7% of pulmonary small cell carcinomas, 42.0% of extrapulmonary small cell carcinomas (range, 33.3–53.3% for the various sites), and 0% of Merkel cell carcinomas. Cytokeratin 20 staining was consistently negative in pulmonary small cell carcinomas, and positive in 4.0% of extrapulmonary small cell carcinomas and 100% of Merkel cell carcinomas. Conclusions.—Immunostaining for TTF-1, especially when combined with immunostaining for CK20, can aid in the distinction between Merkel cell carcinoma and small cell carcinoma (both pulmonary and extrapulmonary). However, in individual cases, these markers cannot be used to distinguish between pulmonary and extrapulmonary small cell carcinomas due to the extensive overlap in immunophenotypes.

scholarly journals DEK expression in Merkel cell carcinoma and small cell carcinoma

2012 ◽  
Vol 39 (8) ◽  
pp. 753-757 ◽  
Author(s):  
Rajiv M. Patel ◽  
Laura L. Walters ◽  
Ferdinand Kappes ◽  
Rohit Mehra ◽  
Douglas R. Fullen ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Small Cell ◽  
Merkel Cell

Immunohistochemical Distinction Between Merkel Cell Carcinoma and Small Cell Carcinoma of the Lung

2006 ◽  
Vol 28 (2) ◽  
pp. 99-104 ◽  
Author(s):  
Mattheos Bobos ◽  
Prodromos Hytiroglou ◽  
Ioannis Kostopoulos ◽  
Georgios Karkavelas ◽  
Constantine S. Papadimitriou
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Small Cell ◽  
Merkel Cell

scholarly journals Comparison of CD23 staining patterns in Merkel cell carcinoma and non-cutaneous small cell carcinoma

2009 ◽  
Vol 36 (2) ◽  
pp. 206-210 ◽  
Author(s):  
Jason Carvalho ◽  
Douglas Fullen ◽  
Lori Lowe ◽  
Lyndon Su ◽  
Linglei Ma
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Small Cell ◽  
Merkel Cell

scholarly journals Merkel cell polyomavirus and extrapulmonary small cell carcinoma

2013 ◽  
Vol 6 (4) ◽  
pp. 1049-1052 ◽  
Author(s):  
KATHRYN C. HOURDEQUIN ◽  
JOEL A. LEFFERTS ◽  
JEOFFRY B. BRENNICK ◽  
MARC S. ERNSTOFF ◽  
GREGORY J. TSONGALIS ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Merkel Cell Polyomavirus ◽  
Merkel Cell ◽  
Extrapulmonary Small Cell Carcinoma

scholarly journals Vulvar Merkel Cell Carcinoma: A Rare Entity

2011 ◽  
Vol 3 (3) ◽  
pp. 145-146
Author(s):  
Monica Soni ◽  
Sudesh Aggarwal ◽  
Prasoon Soni ◽  
Puja Gupta ◽  
Shaifali Dadhich ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Neck Region ◽  
Small Cell ◽  
Rare Entity ◽  
Merkel Cell ◽  
Head And Neck Region ◽  
Vulvar Tumor ◽  
Trabecular Carcinoma

ABSTRACT Merkel cell carcinoma is a primary small cell carcinoma of the skin that resembles oat cell carcinomas of the lung. This tumor has a predilection for head and neck region but may rarely occur as isolated vulvar tumor. It has aggressive malignant behavior and should not be missed while evaluating vulvar masses. We report a case of 45-year-old Mrs I, who presented with recurrent vulvar swelling and was diagnosed as stage III Merkel cell carcinoma of the vulva. Synonyms Primary neuroendocrine carcinoma, Trabecular carcinoma, Primary small cell carcinoma, Cutaneous apudoma.

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