Further studies on neural tube defects caused by concanavalin A in early chick embryos

1976 ◽  
Vol 32 (8) ◽  
pp. 1050-1052 ◽  
Author(s):  
H. Lee ◽  
R. G. Nagele ◽  
G. W. Kalmus
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Concanavalin A ◽  
Chick Embryos

Concanavalin A-induced Open Neural Tube Defects in Chick Embryos

1996 ◽  
Vol 36 (10) ◽  
pp. 691-697 ◽  
Author(s):  
Takayuki INAGAKI ◽  
Kyu-Chang WANG ◽  
Russell G. HIGBEE ◽  
David G. MCLONE ◽  
Paul A. KNEPPER
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Concanavalin A ◽  
Chick Embryos

Concanavalin A binding of alpha-fetoprotein in amniotic fluid as an aid in the diagnosis of neural tube defects.

1981 ◽  
Vol 27 (10) ◽  
pp. 1658-1660 ◽  
Author(s):  
P K Buamah ◽  
P Taylor ◽  
A M Ward
Keyword(s):  
Spina Bifida ◽  
Amniotic Fluid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Concanavalin A ◽  
Gestational Age ◽  
Alpha Fetoprotein ◽  
Normal Outcome ◽  
Fetal Malformations ◽  
Open Spina Bifida

Abstract Concanavalin A nonreactive alpha-fetoprotein was determined in samples of amniotic fluid from 16 abnormal pregnancies complicated by anencephaly (7), open spina bifida (6), intra-uterine death (1), anencephaly with exomphalos (1), or open spina bifida with exomphalos (1), and in amniotic fluid from 50 normal pregnancies with gestational age between 13 and 24 weeks. In all 16 cases with fetal malformations, the proportion of nonreactive alpha-fetoprotein was significantly decreased (median 5.3%) as compared with amniotic fluid from pregnancies with a normal outcome (median 39.7%). The results confirm that this measurement is useful in the diagnosis of neural tube defects, especially when the concentration of alpha-fetoprotein in amniotic fluid is normal or only slightly above normal and gestational age is uncertain.

Chronological changes of re-closure capacity in surgically induced spinal open neural tube defects of chick embryos

2000 ◽  
Vol 292 (3) ◽  
pp. 151-154 ◽  
Author(s):  
Ki-Bum Sim ◽  
Byung-Kyu Cho ◽  
Yun Jin Lee ◽  
Myung Sook Lee ◽  
Kyu-Chang Wang
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Chick Embryos ◽  
Surgically Induced

scholarly journals Analysis of the effects of Streptomyces hyaluronidase on formation of the neural tube

Development ◽  
1983 ◽  
Vol 73 (1) ◽  
pp. 1-15
Author(s):  
Gary C. Schoenwolf ◽  
Marilyn Fisher
Keyword(s):  
Spinal Cord ◽  
Extracellular Matrix ◽  
Hyaluronic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Developmental Process ◽  
Chick Embryos ◽  
In Ovo ◽  
Dorsal Midline ◽  
Specific Protease

Chick embryos at stages 8 to 9 were treated in ovo with Streptomyces hyaluronidase (SH) to determine whether neurulation occurs normally in embryos depleted of hyaluronic acid, a major component of the extracellular matrix. Open neural tube defects occurred in 60–94 % (depending on the particular enzyme batch) of the embryos treated with SH and examined after an additional 24 h of incubation. Defects were confined mainly to the spinal cord. The neural folds underwent elevation in defective regions but failed to converge and fuse across the dorsal midline. The extracellular matrix of embryos treated with SH was depleted consistently, as determined with sections stained with Alcian blue. Control experiments were done to ensure that neural tube defects were not caused by non-specific protease contamination of SH, or by digestion products of hyaluronic acid. We propose several plausible and testable mechanisms through which the extracellular matrix might influence the complex developmental process of neurulation.

NEURAL TUBE DEFECTS OF CHICK EMBRYOS

1971 ◽  
Vol 30 (1) ◽  
pp. 68-74 ◽  
Author(s):  
KENNETH P. JOHNSON ◽  
RADMILA KLASNJA ◽  
RICHARD T. JOHNSON
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Chick Embryos

scholarly journals Morphological study of surgically induced open neural tube defects in chick embryos--postoperative 24 hours

1994 ◽  
Vol 9 (2) ◽  
pp. 116 ◽  
Author(s):  
Heon You ◽  
Ki Bum Sim ◽  
Kyu Chang Wang ◽  
Dong Gyu Kim ◽  
Hyun Jib Kim
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Morphological Study ◽  
Chick Embryos ◽  
Surgically Induced

CONCANAVALIN-A REACTIVITY OF AMNIOTIC FLUID ALPHA-FETOPROTEIN IN DIAGNOSIS OF NEURAL-TUBE DEFECTS

The Lancet ◽  
1979 ◽  
Vol 314 (8148) ◽  
pp. 906 ◽  
Author(s):  
P. Hindersson ◽  
K. Toftager-Larsen ◽  
B. Nørgaard-Pedersen
Keyword(s):  
Amniotic Fluid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Concanavalin A ◽  
Alpha Fetoprotein
Sign in / Sign up

Export Citation Format

Share Document