Dimaprit—[S-[3-(N,N-dimethylamino)propyl]isothiourea]—A highly specific histamine H2-receptor agonist. Part 1, pharmacology

1994 ◽  
Vol 43 (3-4) ◽  
pp. 132-138
Author(s):  
M. E. Parsons ◽  
D. A. A. Owen ◽  
C. R. Ganellin ◽  
G. J. Durant
Keyword(s):  
Receptor Agonist ◽  
Histamine H2 Receptor ◽  
H2 Receptor

Amselamine, a new selective histamine H2-receptor agonist

1994 ◽  
Vol 4 (16) ◽  
pp. 1913-1916 ◽  
Author(s):  
Henk van der Goot ◽  
John Ch. Eriks ◽  
Rob Leurs ◽  
Hendrik Timmerman
Keyword(s):  
Receptor Agonist ◽  
Histamine H2 Receptor ◽  
H2 Receptor

Amthamine: A new potent and selective histamine H2-receptor agonist

1992 ◽  
Vol 25 ◽  
pp. 277-278 ◽  
Author(s):  
G. Coruzzi ◽  
M. Adami ◽  
G. Bertaccini ◽  
H. Timmerman
Keyword(s):  
Receptor Agonist ◽  
Histamine H2 Receptor ◽  
H2 Receptor

The new potent and selective histamine H2 receptor agonist amthamine as a tool to study gastric secretion

1993 ◽  
Vol 348 (1) ◽  
pp. 77-81 ◽  
Author(s):  
Gabriella Coruzzi ◽  
Hendrik Timmerman ◽  
Maristella Adami ◽  
Giulio Bertaccini
Keyword(s):  
Gastric Secretion ◽  
Receptor Agonist ◽  
Histamine H2 Receptor ◽  
H2 Receptor

Coordination of Cl- secretion and contraction by a histamine H2-receptor agonist in guinea pig distal colon

1993 ◽  
Vol 265 (5) ◽  
pp. G973-G978 ◽  
Author(s):  
H. J. Cooke ◽  
Y. Z. Wang ◽  
R. Rogers
Keyword(s):  
Large Amplitude ◽  
Receptor Agonist ◽  
Inflammatory Diseases ◽  
Short Circuit ◽  
Muscle Tension ◽  
Distal Colon ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Neural Connections ◽  
Food Antigens

Short-circuit current (Isc) was measured simultaneously with muscle tension recorded in the longitudinal or circumferential axis from strain-gauge transducers sutured to the serosal surface of whole thickness segments of distal colon from guinea pigs. Isc and the amplitude and frequency of small-amplitude phasic contractions were stable for several hours. The histamine H2-receptor agonist dimaprit (5-10 microM) evoked recurrent increases in Isc at a frequency of 0.32-0.37 cycles/min. Associated with each cyclical Isc response was an increase in muscle tension indicative of large-amplitude phasic contractions. Recurrent cycles of Isc and associated large-amplitude phasic contractions were abolished by 10 microM cimetidine. In the presence of dimaprit, severing the neural connections between the myenteric and submucosal plexuses abolished the large-amplitude phasic contractions but not cyclical Isc. The results suggest that coordination of cyclical secretion and large-amplitude contraction during chronic activation of histamine H2 receptors requires intact neural connections between the submucosal and myenteric plexuses. The findings provide potential mechanisms to explain altered motility and ion transport during inflammatory diseases or allergic responses to food antigens.

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