The hypolipidemic effect of SU-13,437 in rats with natural endogenous hypertriglyceridemia

BACKGROUND: Shanmei Capsule is a famous preparation in China. However, the related mechanism of Shanmei Capsule against hyperlipidemia has yet to be revealed. OBJECTIVE: To elucidate underlying mechanism of Shanmei Capsule against hyperlipidemia through network pharmacology approach and molecular docking. METHODS: Active ingredients, targets of Shanmei Capsule as well as targets for hyperlipidemia were screened based on database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment were performed via Database for Annotation, Visualization, and Integrated Discovery (DAVID) 6.8 database. Ingredient-target-disease-pathway network was visualized utilizing Cytoscape software and molecular docking was performed by Autodock Vina. RESULTS: Seventeen active ingredients in Shanmei Capsule were screened out with a closely connection with 34 hyperlipidemia-related targets. GO analysis revealed 40 biological processes, 5 cellular components and 29 molecular functions. A total of 15 signal pathways were enriched by KEGG pathway enrichment analysis. The docking results indicated that the binding activities of key ingredients for PPAR-α are equivalent to that of the positive drug lifibrate. CONCLUSIONS: The possible molecular mechanism mainly involved PPAR signaling pathway, Bile secretion and TNF signaling pathway via acting on MAPK8, PPARγ, MMP9, PPARα, FABP4 and NOS2 targets.

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Hypolipidemic effect of α-mono-p-myristyloxy-α'-methylcinnamoyl glycerol (LK-903) in rats

Biochemical Pharmacology ◽

10.1016/0006-2952(78)90338-6 ◽

1978 ◽

Vol 27 (22) ◽

pp. 2631-2635 ◽

Cited By ~ 7

Author(s):

Takashima Kohki ◽

Ohyama Kazuaki ◽

Mori Tetsuji ◽

Takeyama Shigeyuki

Keyword(s):

Hypolipidemic Effect

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The hypolipidemic effect and antithrombotic activity of Mucuna pruriens protein hydrolysates

Food & Function ◽

10.1039/c5fo01012h ◽

2016 ◽

Vol 7 (1) ◽

pp. 434-444 ◽

Cited By ~ 11

Author(s):

Francisco Herrera Chalé ◽

Jorge Carlos Ruiz Ruiz ◽

David Betancur Ancona ◽

Juan José Acevedo Fernández ◽

Maira Rubi Segura Campos

Keyword(s):

Protein Hydrolysates ◽

Mucuna Pruriens ◽

Hypolipidemic Effect ◽

Antithrombotic Activity ◽

Protein Concentrates ◽

Enzymatic Systems ◽

Peptide Fractions

Hydrolysates and peptide fractions (PF) obtained fromM. pruriensprotein concentrates with commercial and digestive enzymatic systems were studied for their hypolipidemic and antithrombotic activities.

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Antidiabetic and Antihyperlipidemic Effects ofClitocybe nudaon Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2014/981046 ◽

2014 ◽

Vol 2014 ◽

pp. 1-14 ◽

Cited By ~ 3

Author(s):

Mei-Hsing Chen ◽

Cheng-Hsiu Lin ◽

Chun-Ching Shih

Keyword(s):

Skeletal Muscle ◽

Protein Kinase ◽

Glucose Transporter ◽

Body Weight Gain ◽

Glucose Production ◽

Hypolipidemic Effect ◽

Glucose Transporter 4 ◽

High Fat ◽

Hepatic Expression ◽

Amp Activated Protein Kinase

The objective of this study was to evaluate the antihyperlipidemic and antihyperglycemic effects and mechanism of the extract ofClitocybe nuda(CNE), in high-fat- (HF-) fed mice. C57BL/6J was randomly divided into two groups: the control (CON) group was fed with a low-fat diet, whereas the experimental group was fed with a HF diet for 8 weeks. Then, the HF group was subdivided into five groups and was given orally CNE (including C1: 0.2, C2: 0.5, and C3: 1.0 g/kg/day extracts) or rosiglitazone (Rosi) or vehicle for 4 weeks. CNE effectively prevented HF-diet-induced increases in the levels of blood glucose, triglyceride, insulin (P<0.001,P<0.01,P<0.05, resp.) and attenuated insulin resistance. By treatment with CNE, body weight gain, weights of white adipose tissue (WAT) and hepatic triacylglycerol content were reduced; moreover, adipocytes in the visceral depots showed a reduction in size. By treatment with CNE, the protein contents of glucose transporter 4 (GLUT4) were significantly increased in C3-treated group in the skeletal muscle. Furthermore, CNE reduces the hepatic expression of glucose-6-phosphatase (G6Pase) and glucose production. CNE significantly increases protein contents of phospho-AMP-activated protein kinase (AMPK) in the skeletal muscle and adipose and liver tissues. Therefore, it is possible that the activation of AMPK by CNE leads to diminished gluconeogenesis in the liver and enhanced glucose uptake in skeletal muscle. It is shown that CNE exhibits hypolipidemic effect in HF-fed mice by increasing ATGL expression, which is known to help triglyceride to hydrolyze. Moreover, antidiabetic properties of CNE occurred as a result of decreased hepatic glucose production via G6Pase downregulation and improved insulin sensitization. Thus, amelioration of diabetic and dyslipidemic states by CNE in HF-fed mice occurred by regulation of GLUT4, G6Pase, ATGL, and AMPK phosphorylation.

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Legumin from chickpea: hypolipidemic effect in the liver of hypercholesterolemic rats

Nutrition & Food Science ◽

10.1108/nfs-10-2013-0115 ◽

2014 ◽

Vol 44 (5) ◽

pp. 378-388 ◽

Cited By ~ 7

Author(s):

Ana L. Amaral ◽

Ederlan S. Ferreira ◽

Valdir A. Neves ◽

Aureluce Demonte

Keyword(s):

Lipid Metabolism ◽

Cholic Acid ◽

Hdl Cholesterol ◽

Normal Diet ◽

Single Daily Dose ◽

High Cholesterol Diet ◽

Hypolipidemic Effect ◽

Content Type ◽

Daily Dose ◽

11S Globulin

Purpose – This paper aims to determine the effects of 11S globulin isolated from Chickpea (Cicer arietinum L.) on lipid metabolism in animals subjected to a hypercholesterolemic and hyperlipidemic diet and compared to the drug simvastatin. Design/methodology/approach – Thirty-six male Wistar rats, kept in individual cages and under appropriate conditions, were separated into groups that were fed a normal diet (STD) containing casein as protein source and according to AIN-93G; a high-cholesterol diet (HC), normal diet plus 1 per cent cholesterol and 0.5 per cent cholic acid and 20 per cent coconut oil; HC diet plus the isolated 11S globulin (300 mg/kg/day); and HC diet plus the simvastatin (50 mg/kg/day), both dissolved in saline and administered by gavage for 28 days. After this time, the animals were killed. Findings – The results indicated that the addition of 1 per cent cholesterol and 0.5 per cent cholic acid induced hypercholesterolemia in the animals without interfering with their weight gain. Analyses of total cholesterol (TC), HDL-cholesterol (HDL-C) and triglycerides (TG) in the plasma, and TC and TG in the liver were made. The results show that the protein isolated from chickpea, and given as a single daily dose, did not affect the levels of plasma TC and its fractions, although decreasing the TG levels. Unlike the simvastatin, the chickpea protein significantly reduced TC and TG in the liver relative to HC group. Originality/value – A single daily dose of 11S globulin from chickpea contributed as only as additional 2.8 per cent of dietary protein intake. These findings demonstrate that 11S chickpea protein acts as a functional agent in the lipid metabolism in addition to its nutritional properties.

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