Replication and differentiation in vitro of epidermal cells from normal human skin and from benign (psoriasis) and malignant (basal cell cancer) hyperplasia

In Vitro ◽  
1972 ◽  
Vol 8 (3) ◽  
pp. 237-250 ◽  
Author(s):  
B. Allen Flaxman
1984 ◽  
Vol 12 (2) ◽  
pp. 89-97
Author(s):  
Graham R. Elliott ◽  
H.E. Amos ◽  
James W. Bridges

The rate of growth of normal human skin fibroblasts was inhibited in a dose related, reversible, fashion by practolol (N-4-(2-hydroxy)-3 (1-methyl)-aminopropoxyphenylacetamine) (ID50 1.35 ± 0.14 x 10-3M), propranolol (1-(isopropylamino)-3(1-naphthyl-oxy)-2-propranolol) (ID50 0.145 ± 0.02 x 10-3M) and paracetamol (N-(4-hydroxyphenyl) acetamide) (ID50 0.85 ± 0.2 x 10-3M). Skin fibroblasts isolated from a psoriasis patient were more sensitive towards practolol (ID50 0.48 ± 0.14 x 10-3M) and propranolol (ID50 0.032 ± 0.002 x 10-3M), but less sensitive towards paracetamol (ID50 1.3 ± 0.07 x 10-3M). In vitro generated metabolites of practolol, using normal or Arochlor 1254-pretreated hamster liver preparations, and structural analogues of practolol had no effect upon the growth of either cell type.


2003 ◽  
Vol 148 (1) ◽  
pp. 102-109 ◽  
Author(s):  
C.M.L.J. Tilli ◽  
F.C.S. Ramaekers ◽  
J.L.V. Broers ◽  
C.J. Hutchison ◽  
H.A.M. Neumann

1998 ◽  
Vol 37 (1) ◽  
pp. 18-22 ◽  
Author(s):  
Vincenzo Ruocco ◽  
Sarah Brenner ◽  
Eleonora Ruocco ◽  
Francesca De Angelis ◽  
Maria Luisa Lombardi

Phytomedicine ◽  
2012 ◽  
Vol 19 (13) ◽  
pp. 1223-1227 ◽  
Author(s):  
Jeong-Hyun Lee ◽  
Hye-Lee Kim ◽  
Mi Hee Lee ◽  
Kyung Eun You ◽  
Byeong-Ju Kwon ◽  
...  

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