N-acetyl-β-D-glucosaminidase, alanine aminopeptidase and protein: Creatinine ratio as early indicators of diabetic microangiopathy

1994 ◽  
Vol 9 (1) ◽  
pp. 5-8 ◽  
Author(s):  
K. Srikrishna ◽  
A. S. Kanagasabapathy ◽  
Lily John
Nephrology ◽  
2000 ◽  
Vol 5 (3) ◽  
pp. A93-A93
Author(s):  
Sj Chadban ◽  
P Kerr ◽  
E Briganti ◽  
D Dunstan ◽  
M De Courten ◽  
...  

2012 ◽  
Author(s):  
Jeannie Annan ◽  
Tom Bundervoet ◽  
Gabrielle Cole ◽  
Paul Bolton ◽  
Judith Bass

2018 ◽  
Vol 110 (4) ◽  
pp. 483-501 ◽  
Author(s):  
Hyun-Joo Jeon ◽  
Shavaun M. Wall ◽  
Carla A. Peterson ◽  
Gayle J. Luze ◽  
Mark E. Swanson

2011 ◽  
Vol 9 (2) ◽  
pp. 90 ◽  
Author(s):  
Rohola Hemmati ◽  
Mojgan Gharipour ◽  
Hasan Shemirani ◽  
Alireza Khosravi ◽  
Elham Khosravi ◽  
...  

Background:Appearance of microalbuminuria, particularly in patients with hypertension, might be associated with a higher prevalence of left ventricular (LV) dysfunction and geometric abnormalities. This study was undertaken to determine whether high urine albumin to creatinine ratio (UACR) as a sensitive marker for microalbuminuria can be associated with LV hypertrophy (LVH) and systolic and diastolic LV dysfunction.Methods:The study population consisted of 125 consecutive patients with essential uncomplicated hypertension. Urine albumin and creatinine concentration was determined by standard methods. LVH was defined as a LV mass index >100 g/m2 of body surface area in women and >130 g/m2 in men. Echocardiographic LV systolic and diastolic parameters were measured.Results:The prevalence of microalbuminuria in patients with essential hypertension was 5.6 %. UACR was significantly no different in patients with LVH than in patients with normal LV geometry (21.26 ± 31.55 versus 17.80 ± 24.52 mg/mmol). No significant correlation was found between UACR measurement and systolic and diastolic function parameters, including early to late diastolic peak velocity (E/A) ratio (R=-0.192, p=0.038), early diastolic peak velocity to early mitral annulus velocity (E/E') ratio (R=-0.025, p=0.794), LV ejection fraction (R=0.008, p=0.929), and LV mass (R=-0.132, p=0.154). According to the receiver operator characteristic (ROC) curve analysis, UACR measurement was not an acceptable indicator of LVH with areas under the ROC curves 0.514 (95 % confidence interval 0.394–0.634). The optimal cut-off value for UACR for predicting LVH was identified at 9.4, yielding a sensitivity of 51.6 % and a specificity of 48.3 %.Conclusion:In patients with uncomplicated essential hypertension, abnormal systolic and diastolic LV function and geometry cannot be effectively predicted by the appearance of microalbuminuria.


Diabetes ◽  
1976 ◽  
Vol 25 (1) ◽  
pp. 24-28 ◽  
Author(s):  
J. H. Karam ◽  
M. Rosenthal ◽  
J. J. O'Donnell ◽  
E. Tsalikian ◽  
M. Lorenzi ◽  
...  

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