Glomerular immune complex deposition, circulating immune complexes, and antibodies in experimental insulinopenic diabetes

1982 ◽  
Vol 41 (1) ◽  
pp. 293-300
Author(s):  
U. Fuchs ◽  
P. Caffier ◽  
J. Schade ◽  
R. v. Baehr ◽  
K. Malberg ◽  
...  
Keyword(s):  
Immune Complex ◽  
Immune Complexes ◽  
Circulating Immune Complexes ◽  
Immune Complex Deposition ◽  
Complex Deposition

Localization of Immune Complexes in the Basement Membrane of the Ductuli Efferentes of the Rhesus Monkey

1980 ◽  
Vol 38 ◽  
pp. 456-457
Author(s):  
D. Marsh
Keyword(s):  
Basement Membrane ◽  
Fluorescence Microscopy ◽  
Rhesus Monkey ◽  
Immune Complex ◽  
Immune Complexes ◽  
Vas Deferens ◽  
Frozen Sections ◽  
Efferent Ducts ◽  
Complex Deposition ◽  
Sperm Antibodies

As a result of vasectomy, spermatozoa are confined to the epididymis and vas deferens, where they degenerate, releasing antigens that enter the circulation or are engulfed by macrophages. Multiple antigens of the sperm can elicit production of autoantibodies; circulating anti-sperm antibodies are found in a large percentage of vasectomized men, indicating the immunogenicity of the sperm. The increased prevalence of macrophages in the liomen of the rhesus monkey testicular efferent ducts after vasectomy led to further study of this region. Frozen sections were used for evaluation of immunopathological status by fluorescence microscopy with fluorescein-conjugated antibody. Subsequent granular deposits of immune complexes were revealed by positive immunofluorescence staining for complement. The immune complex deposition in the basement membrane surrounding the efferent ducts implies that this region is involved in antigen leakage (Fig. 1).

Curcumin attenuates lupus nephritis upon interaction with regulatory T cells in New Zealand Black/White mice

2012 ◽  
Vol 110 (1) ◽  
pp. 69-76 ◽  
Author(s):  
Hyojung Lee ◽  
Hyunseong Kim ◽  
Gihyun Lee ◽  
Hwan-Suck Chung ◽  
Hyunsu Bae
Keyword(s):  
New Zealand ◽  
Lupus Nephritis ◽  
Immune Complex ◽  
Serum Levels ◽  
Therapeutic Effects ◽  
Igg Antibodies ◽  
Renal Inflammation ◽  
Female Mice ◽  
Immune Complex Deposition ◽  
Complex Deposition

Curcumin has been used in Asian traditional medicine for its medicinal properties. Recent studies have demonstrated that curcumin has antioxidant, anti-tumour and anti-inflammatory activities. The aim of the present study is to investigate the effects of curcumin on established lupus nephritis (LN) in New Zealand Black/White (NZB/W) F1 female mice, in particular, its interaction with regulatory T (Treg) cells. Starting at 18 weeks of age, mice were fed a standard diet or a diet containing 1 % curcumin until the end of the study. The proteinuria level and the serum levels of IgG1, IgG2a and anti-double-stranded DNA (dsDNA) IgG antibodies were measured. Additionally, IgG immune complex deposition in the glomeruli and renal inflammation were compared between curcumin-treated mice and control mice. Curcumin decreased the proteinuria level and serum levels of IgG1, IgG2a and anti-dsDNA IgG antibodies in NZB/W F1 female mice. IgG immune complex deposition in the glomeruli was reduced in curcumin-treated mice. Furthermore, renal inflammation was also decreased after curcumin treatment. Interestingly, these therapeutic effects of curcumin disappeared after Treg depletion by anti-CD25 antibody injection. Curcumin exerted a protective effect against LN in NZB/W F1 mice. We speculate that the protective effects of curcumin in LN may involve, at least in part, its interaction with Treg cells.

Immune complex deposition in Bowman's capsule is associated with parietal podocytes

1994 ◽  
Vol 173 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Ian W. Gibson ◽  
Thomas T. Downie ◽  
Ian A. R. More ◽  
George B. M. Lindop
Keyword(s):  
Immune Complex ◽  
Immune Complex Deposition ◽  
Complex Deposition ◽  
Bowman's Capsule

Immune Complex Deposition in Adult Male Sprague-Dawley Rats Chronically Immunized with GnRH

2005 ◽  
Vol 54 (5) ◽  
pp. 292-310 ◽  
Author(s):  
Louis Vargas ◽  
Richard Sewell ◽  
Aileen Marshall ◽  
Josephine Galatioto ◽  
Yun-Yen Tsong ◽  
...  
Keyword(s):  
Immune Complex ◽  
Adult Male ◽  
Sprague Dawley ◽  
Immune Complex Deposition ◽  
Sprague Dawley Rats ◽  
Complex Deposition
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