scholarly journals The shape of the glucose concentration curve during an oral glucose tolerance test predicts risk for type 1 diabetes

Diabetologia ◽  
2017 ◽  
Vol 61 (1) ◽  
pp. 84-92 ◽  
Author(s):  
Heba M. Ismail ◽  
◽  
Ping Xu ◽  
Ingrid M. Libman ◽  
Dorothy J. Becker ◽  
...  
2019 ◽  
Vol 20 (4) ◽  
pp. 408-413
Author(s):  
Heba M. Ismail ◽  
Carmella Evans‐Molina ◽  
Linda A. DiMeglio ◽  
Dorothy J. Becker ◽  
Ingrid Libman ◽  
...  

2021 ◽  
Vol 12 ◽  
Author(s):  
Othmar Moser ◽  
Max L. Eckstein ◽  
Alexander Mueller ◽  
Norbert J. Tripolt ◽  
Hakan Yildirim ◽  
...  

Prolonged fasting has shown beneficial effects in healthy individuals and in people with chronic diseases. In type 1 diabetes, the effect or even the feasibility of fasting is unclear. We aimed to assess the impact and safety of prolonged fasting in adults with type 1 diabetes. Glycemia was assessed during overnight fasting (12 hours) vs. prolonged fasting (36 hours) via an intermittently-scanned continuous glucose monitoring system. Anthropometric data, metabolic and hormonal markers were compared between both trial arms. After each fasting period, a 75 g oral glucose tolerance test was performed and plasma glucose levels and hormones were assessed. Data were compared via paired t-tests and mixed-model regressions (p ≤ 0.05). Twenty individuals with type 1 diabetes (7 females) with a mean ± SD age of 35 ± 11 years, body mass index (BMI) 24.8 ± 2.8 kg/m2 and HbA1c 54 ± 7 mmol/mol were included. Hypoglycemia/hour (70 mg/dL; <3.9 mmol/L) was similar in both trial arms (12 hrs: 0.07 ± 0.06 vs. 36 hrs: 0.05 ± 0.03, p=0.21). Glycemic excursions during the oral glucose tolerance test were not different after the two fasting periods. Beta-hydroxybutyrate levels were higher after prolonged fasting (p=0.0006). Our study showed that people with type 1 diabetes can safely perform a 36 hours fasting period with a low risk of hypoglycemia and ketoacidosis.Clinical Trial RegistrationDRKS.de, identifier DRKS00016148.


2020 ◽  
Vol 150 (2) ◽  
pp. 234-240 ◽  
Author(s):  
Ainoha García‐Claver ◽  
Raquel Ramos‐Corral ◽  
Concepción Laviña‐Fañanás ◽  
Isabel Solans‐Blecua ◽  
José Puzo‐Foncillas

2005 ◽  
Vol 11 ◽  
pp. 28
Author(s):  
Fanny Rodriguez Vallejo ◽  
Juan Manuel Rios Torres ◽  
Francisco J. Gomez-Pérez ◽  
Juan A. Rull Rodrigo ◽  
Bernardo Pérez Enriquez

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