scholarly journals Test-retest reliability of tone- and 40 Hz train-evoked gamma oscillations in female rats and their sensitivity to low-dose NMDA channel blockade

2021 ◽  
Author(s):  
Muhammad Ummear Raza ◽  
Digavalli V. Sivarao
Keyword(s):  
Low Dose ◽  
Gamma Oscillations ◽  
Female Rats ◽  
Channel Blockade ◽  
Retest Reliability ◽  
Nmda Channel ◽  
Test Retest Reliability ◽  
40 Hz

scholarly journals Test-retest reliability of tone- and 40 Hz train-evoked gamma oscillations in female rats and their sensitivity to low-dose NMDA channel blockade

2021 ◽  
Author(s):  
Muhammad Ummear Raza ◽  
Digavalli V. Sivarao
Keyword(s):  
Gamma Oscillations ◽  
Female Rats ◽  
Network Activity ◽  
Multiple Time ◽  
Evoked Responses ◽  
Retest Reliability ◽  
Sensory Evoked ◽  
Test Retest Reliability ◽  
40 Hz

Rationale: Schizophrenia patients consistently show deficits in sensory-evoked broadband gamma oscillations and click-evoked entrainment at 40 Hz, called the 40 Hz auditory steady-state response (ASSR). Since such evoked oscillations depend on cortical N-methyl D-aspartic acid (NMDA)-mediated network activity, they can serve as pharmacodynamic biomarkers in the preclinical development of drug candidates engaging these circuits. However, there is little test-retest reliability data in preclinical species, a prerequisite for within-subject testing paradigms. Objectives: We investigated the long-term stability of these measures in a rodent model. Methods: Female rats with chronic epidural implants were used to record tone- and 40 Hz click-evoked responses at multiple time points and across six sessions, spread over 3 weeks. We assessed reliability using intraclass correlation coefficients (ICC). Separately, we used mixed-effects ANOVA to examine time and session effects. Individual subject variability was determined using the coefficient of variation (CV). Lastly, to illustrate the importance of long-term measure stability for within-subject testing design, we used low to moderate doses of an NMDA antagonist MK801 (0.025-0.15 mg/kg) to disrupt the evoked responses. Results: We found that 40 Hz ASSR showed good reliability (ICC=0.60-0.75) while the reliability of tone-evoked gamma ranged from poor to good (0.33-0.67). We noted time but no session effects. Subjects showed a lower variance for ASSR over tone-evoked gamma. Both measures were dose-dependently attenuated by NMDA antagonism. Conclusion: Overall, while both measures use NMDA transmission, 40 Hz ASSR showed superior psychometric properties of higher ICC and lower CV, relative to tone-evoked gamma.

scholarly journals Test–retest reliability of tibiofemoral joint space width measurements made using a low-dose standing CT scanner

2016 ◽  
Vol 46 (2) ◽  
pp. 217-222 ◽  
Author(s):  
Neil A. Segal ◽  
John Bergin ◽  
Andrew Kern ◽  
Christian Findlay ◽  
Donald D. Anderson
Keyword(s):  
Low Dose ◽  
Joint Space Width ◽  
Joint Space ◽  
Ct Scanner ◽  
Retest Reliability ◽  
Tibiofemoral Joint ◽  
Width Measurements ◽  
Test Retest Reliability ◽  
Space Width

The free-exploratory paradigm as a model of trait anxiety in female rats: Test–retest reliability

2014 ◽  
Vol 580 ◽  
pp. 137-141 ◽  
Author(s):  
Débora Ramiro de Oliveira ◽  
Tiago Costa Goes ◽  
Flavia Teixeira-Silva
Keyword(s):  
Trait Anxiety ◽  
Female Rats ◽  
Retest Reliability ◽  
Test Retest Reliability

scholarly journals MEG and EEG demonstrate similar test-retest reliability of the 40 Hz auditory steady-state response

2017 ◽  
Vol 114 ◽  
pp. 16-23 ◽  
Author(s):  
Kristina T. Legget ◽  
Allison K. Hild ◽  
Sarah E. Steinmetz ◽  
Steven T. Simon ◽  
Donald C. Rojas
Keyword(s):  
Steady State ◽  
Steady State Response ◽  
Retest Reliability ◽  
State Response ◽  
Similar Test ◽  
Auditory Steady State Response ◽  
Test Retest Reliability ◽  
40 Hz

scholarly journals Test–Retest Reliability of the Assessment of Fatty Liver Disease Using Low-Dose Computed Tomography in Cardiac Patients

2021 ◽  
Vol 8 ◽  
Author(s):  
Antti Hokkanen ◽  
Hanna Hämäläinen ◽  
Tiina M. Laitinen ◽  
Tomi P. Laitinen
Keyword(s):  
Computed Tomography ◽  
Liver Disease ◽  
Fatty Liver Disease ◽  
Low Dose ◽  
Liver Fat ◽  
Ct Scans ◽  
Liver Fat Content ◽  
Retest Reliability ◽  
Test Retest Reliability ◽  
Low Dose Computed Tomography

Non-alcoholic fatty liver disease (NAFLD) is a common disorder that is associated with the risk of cardiovascular diseases. Therefore, its prevalence is high in patients with coronary artery disease. In myocardial perfusion imaging (MPI), low-dose computed tomography (CT) scans are used for attenuation correction in separate stress and rest studies. Here, the test–retest reliability of CT-based quantification of NAFLD was evaluated using these two CT scans. The study population consisted of 261 patients (156 men and 105 women, age 66 ± 10 years). Quantification of liver fat content was based on the radiodensity of the liver in Hounsfield units as well as in relation to corresponding values of the spleen. NAFLD was observed in 47 subjects (18%). CT quantification has good test–retest reliability in assessing NAFLD, with concordance correlation coefficient (CCC) ranging from 0.512 to 0.923, intraclass correlation coefficient (ICC) ranging from 0.513 to 0.923, and coefficient of variation ranging from 3.1 to 7.0%. Regarding the liver to spleen ratio, CCC for non-NAFLD patients and NAFLD patients was 0.552 and 0.911, respectively. For non-NAFLD patients ICC was 0.553 and NAFLD patients it was 0.913. The coefficient of variation for non-NAFLD and NAFLD patients was 4.9% and 3.1%, respectively. Our results suggest that low-dose CT is a feasible and well repeatable method but amount of liver fat contributes to repeatability. In NAFLD patients CCC and ICC were high reflecting excellent reliability, whereas in non-NAFLD patients test-retest reliability was moderate. Assessment of liver fat content can be used as additional information in studies where a CT scan has been done for other medical reasons, such as for low-dose attenuation correction CT along with MPI.

scholarly journals Test-Retest Reliability of the 40 Hz EEG Auditory Steady-State Response

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e85748 ◽  
Author(s):  
Kristina L. McFadden ◽  
Sarah E. Steinmetz ◽  
Adam M. Carroll ◽  
Steven T. Simon ◽  
Alissa Wallace ◽  
...  
Keyword(s):  
Steady State ◽  
Steady State Response ◽  
Retest Reliability ◽  
State Response ◽  
Auditory Steady State Response ◽  
Test Retest Reliability ◽  
40 Hz

Measuring “Language Access Profiles” in Deaf and Hard-of-Hearing Children With the DHH Language Exposure Assessment Tool

2020 ◽  
pp. 1-25
Author(s):  
Matthew L. Hall ◽  
Stephanie De Anda
Keyword(s):  
Cluster Analysis ◽  
Exposure Assessment ◽  
Hard Of Hearing ◽  
Assessment Tool ◽  
Communication Mode ◽  
Developmental Potential ◽  
Language Access ◽  
Retest Reliability ◽  
Language Exposure ◽  
Test Retest Reliability

Purpose The purposes of this study were (a) to introduce “language access profiles” as a viable alternative construct to “communication mode” for describing experience with language input during early childhood for deaf and hard-of-hearing (DHH) children; (b) to describe the development of a new tool for measuring DHH children's language access profiles during infancy and toddlerhood; and (c) to evaluate the novelty, reliability, and validity of this tool. Method We adapted an existing retrospective parent report measure of early language experience (the Language Exposure Assessment Tool) to make it suitable for use with DHH populations. We administered the adapted instrument (DHH Language Exposure Assessment Tool [D-LEAT]) to the caregivers of 105 DHH children aged 12 years and younger. To measure convergent validity, we also administered another novel instrument: the Language Access Profile Tool. To measure test–retest reliability, half of the participants were interviewed again after 1 month. We identified groups of children with similar language access profiles by using hierarchical cluster analysis. Results The D-LEAT revealed DHH children's diverse experiences with access to language during infancy and toddlerhood. Cluster analysis groupings were markedly different from those derived from more traditional grouping rules (e.g., communication modes). Test–retest reliability was good, especially for the same-interviewer condition. Content, convergent, and face validity were strong. Conclusions To optimize DHH children's developmental potential, stakeholders who work at the individual and population levels would benefit from replacing communication mode with language access profiles. The D-LEAT is the first tool that aims to measure this novel construct. Despite limitations that future work aims to address, the present results demonstrate that the D-LEAT represents progress over the status quo.

Visual-Neural Correlate of Speechreading Ability in Normal-Hearing Adults

1982 ◽  
Vol 25 (4) ◽  
pp. 521-527 ◽  
Author(s):  
David C. Shepherd
Keyword(s):  
Normal Hearing ◽  
Wave Form ◽  
Firing Time ◽  
Neural Firing ◽  
Neural Correlate ◽  
Retest Reliability ◽  
Repeated Word ◽  
Negative Peak ◽  
The Stability ◽  
Test Retest Reliability

In 1977, Shepherd and colleagues reported significant correlations (–.90, –.91) between speechreading scores and the latency of a selected negative peak (VN 130 measure) on the averaged visual electroencephalic wave form. The primary purpose of this current study was to examine the stability, or repeatability, of this relation between these cognitive and neurophysiologic measures over a period of several months and thus support its test-retest reliability. Repeated speechreading word and sentence scores were gathered during three test-retest sessions from each of 20 normal-hearing adults. An average of 56 days occurred from the end of one to the beginning of another speechreading sessions. During each of four other test-retest sessions, averaged visual electroencephalic responses (AVER s ) were evoked from each subject. An average of 49 clays intervened between AVER sessions. Product-moment correlations computed among repeated word scores and VN l30 measures ranged from –.61 to –.89. Based on these findings, it was concluded that the VN l30 measure of visual neural firing time is a reliable correlate of speech-reading in normal-hearing adults.

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