Diffusion tensor imaging shows white matter tracts between human auditory and visual cortex

2011 ◽  
Vol 213 (2-3) ◽  
pp. 299-308 ◽  
Author(s):  
Anton L. Beer ◽  
Tina Plank ◽  
Mark W. Greenlee
Keyword(s):  
Diffusion Tensor Imaging ◽  
Visual Cortex ◽  
White Matter ◽  
Diffusion Tensor ◽  
White Matter Tracts

Diffusion tensor imaging of major white matter tracts in active and recently abstinent methamphetamine users

2014 ◽  
Vol 140 ◽  
pp. e124
Author(s):  
Joanne C. Lin ◽  
R.K. Jan ◽  
T.A. Wouldes ◽  
R.R. Kydd ◽  
B.R. Russell
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
White Matter Tracts

scholarly journals Functional Diffusion Tensor Imaging: Measuring Task-Related Fractional Anisotropy Changes in the Human Brain along White Matter Tracts

PLoS ONE ◽  
2008 ◽  
Vol 3 (11) ◽  
pp. e3631 ◽  
Author(s):  
René C. W. Mandl ◽  
Hugo G. Schnack ◽  
Marcel P. Zwiers ◽  
Arjen van der Schaaf ◽  
René S. Kahn ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Human Brain ◽  
Fractional Anisotropy ◽  
Diffusion Tensor ◽  
White Matter Tracts

scholarly journals Diffusion tensor imaging of frontal lobe white matter tracts in schizophrenia

2006 ◽  
Vol 5 (1) ◽  
Author(s):  
Monte S Buchsbaum ◽  
Peter Schoenknecht ◽  
Yuliya Torosjan ◽  
Randall Newmark ◽  
King-Wai Chu ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Frontal Lobe ◽  
Diffusion Tensor ◽  
White Matter Tracts

scholarly journals Tract Specificity of Age Effects on Diffusion Tensor Imaging Measures of White Matter Health

2021 ◽  
Vol 13 ◽  
Author(s):  
Stephanie Matijevic ◽  
Lee Ryan
Keyword(s):  
Older Adults ◽  
Diffusion Tensor Imaging ◽  
Individual Differences ◽  
White Matter ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
White Matter Integrity ◽  
White Matter Tracts ◽  
Apoe Ε4 ◽  
Age Related

Well-established literature indicates that older adults have poorer cerebral white matter integrity, as measured through diffusion tensor imaging (DTI). Age differences in DTI have been observed widely across white matter, although some tracts appear more sensitive to the effects of aging than others. Factors like APOE ε4 status and sex may contribute to individual differences in white matter integrity that also selectively impact certain tracts, and could influence DTI changes in aging. The present study explored the degree to which age, APOE ε4, and sex exerted global vs. tract specific effects on DTI metrics in cognitively healthy late middle-aged to older adults. Data from 49 older adults (ages 54–92) at two time-points separated by approximately 2.7 years were collected. DTI metrics, including fractional anisotropy (FA) and mean diffusivity (MD), were extracted from nine white matter tracts and global white matter. Results showed that across timepoints, FA and MD increased globally, with no tract-specific changes observed. Baseline age had a global influence on both measures, with increasing age associated with lower FA and higher MD. After controlling for global white matter FA, age additionally predicted FA for the genu, callosum body, inferior fronto-occipital fasciculus (IFOF), and both anterior and posterior cingulum. Females exhibited lower global FA on average compared to males. In contrast, MD was selectively elevated in the anterior cingulum and superior longitudinal fasciculus (SLF), for females compared to males. APOE ε4 status was not predictive of either measure. In summary, these results indicate that age and sex are associated with both global and tract-specific alterations to DTI metrics among a healthy older adult cohort. Older women have poorer white matter integrity compared to older men, perhaps related to menopause-induced metabolic changes. While age-related alterations to white matter integrity are global, there is substantial variation in the degree to which tracts are impacted, possibly as a consequence of tract anatomical variability. The present study highlights the importance of accounting for global sources of variation in DTI metrics when attempting to investigate individual differences (due to age, sex, or other factors) in specific white matter tracts.

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