The Risk-Stratified Osteoporosis Strategy Evaluation study (ROSE): A Randomized Prospective Population-Based Study. Design and Baseline Characteristics

2015 ◽  
Vol 96 (2) ◽  
pp. 167-179 ◽  
Author(s):  
Katrine Hass Rubin ◽  
Teresa Holmberg ◽  
Mette Juel Rothmann ◽  
Mikkel Høiberg ◽  
Reinhard Barkmann ◽  
...  
2019 ◽  
Vol 80 (2) ◽  
pp. 136-137
Author(s):  
Emeric Scharbarg ◽  
Matthieu Wargny ◽  
Brice Leclère ◽  
Patrick Plunian ◽  
Maja Velkovski-Rouyer ◽  
...  

2019 ◽  
Vol 39 (6) ◽  
pp. 553-561 ◽  
Author(s):  
Murray D. Krahn ◽  
Karen E. Bremner ◽  
Claire de Oliveira ◽  
Stephanie N. Dixon ◽  
Phil McFarlane ◽  
...  

Background How and where to initiate dialysis are policy challenges with enormous economic and health consequences. Initiating with home hemodialysis (HD) or peritoneal dialysis (PD) may reduce costs and improve outcomes but evidence is conflicting. Methods We conducted a population-based study in patients aged ≥ 18 years who initiated chronic dialysis in the province of Ontario, Canada from 2006 to 2014 ( N = 12,691) using linked administrative data. Patients were grouped by initial modality: facility HD, facility short daily or slow nocturnal (SD/SN) HD, PD, home HD. We estimated publicly-paid healthcare costs (2015 Canadian dollars; 1 = 0.947 US dollar) and survival, from dialysis initiation to March 2015. Results By 5 years after dialysis initiation, mean 30-day costs (as-treated) for patients receiving PD and home HD were 50% and 64% lower, respectively, than for facility HD patients ($11,011). Approximately 50% of costs were unrelated to dialysis, reflecting high comorbidity in these patients. With covariate adjustment, mean 5-year cumulative costs were similar for initiators of home HD and PD ($304,178 and $349,338) and higher for facility HD initiators ($410,981). The highest 5-year unadjusted survival was for home HD patients (80%), followed by PD (52%), SD/SN HD (50%), and facility HD (42%). Conclusions This study in a large cohort over 9 years provides new population-based evidence suggesting that initiating dialysis at home is cost-effective, with lower costs and better survival, than starting with facility HD. Survival differences persisted after adjustment for baseline characteristics but we could not adjust for functional status or severity of comorbidities.


2015 ◽  
Vol 43 (7) ◽  
pp. 612-620 ◽  
Author(s):  
Der-Chong Tsai ◽  
Li-Ju Lin ◽  
Nicole Huang ◽  
Chih-Chien Hsu ◽  
Shing-Yi Chen ◽  
...  

2004 ◽  
Vol 28 (7) ◽  
pp. 713-724 ◽  
Author(s):  
Nikolaus Becker ◽  
Evelin Deeg ◽  
Alexandra Nieters

Metabolites ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 117 ◽  
Author(s):  
Su Chu ◽  
Mengna Huang ◽  
Rachel Kelly ◽  
Elisa Benedetti ◽  
Jalal Siddiqui ◽  
...  

It is not controversial that study design considerations and challenges must be addressed when investigating the linkage between single omic measurements and human phenotypes. It follows that such considerations are just as critical, if not more so, in the context of multi-omic studies. In this review, we discuss (1) epidemiologic principles of study design, including selection of biospecimen source(s) and the implications of the timing of sample collection, in the context of a multi-omic investigation, and (2) the strengths and limitations of various techniques of data integration across multi-omic data types that may arise in population-based studies utilizing metabolomic data.


2004 ◽  
Vol 46 (S1) ◽  
pp. 104-104
Author(s):  
Alexandra Nieters ◽  
Evelin Deeg ◽  
Nikolaus Becker

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