T1 relaxation times and MR elastography-derived stiffness: new potential imaging biomarkers for the assessment of chronic pancreatitis

2021 ◽  
Author(s):  
Emily Steinkohl ◽  
Søren Schou Olesen ◽  
Tine Maria Hansen ◽  
Asbjørn Mohr Drewes ◽  
Jens Brøndum Frøkjær
Keyword(s):  
Chronic Pancreatitis ◽  
Relaxation Times ◽  
Imaging Biomarkers ◽  
Mr Elastography ◽  
T1 Relaxation

T1 mapping for the diagnosis of early chronic pancreatitis: correlation with Cambridge classification system

2021 ◽  
pp. 20200685
Author(s):  
Monica Cheng ◽  
Mark A Gromski ◽  
Evan L Fogel ◽  
John M DeWitt ◽  
Aashish A Patel ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
T1 Mapping ◽  
Early Stage ◽  
Relaxation Times ◽  
Magnetic Resonance Cholangiopancreatography ◽  
Practical Method ◽  
T1 Relaxation ◽  
Imaging Protocols ◽  
Significant Difference ◽  
The Mean

Objective: This study aims to determine if T1 relaxation time of the pancreas can detect parenchymal changes in early chronic pancreatitis (CP). Methods: This study retrospectively analyzed 42 patients grouped as no CP (Cambridge 0; n = 21), equivocal (Cambridge 1; n = 12) or mild CP (Cambridge 2; n = 9) based on magnetic resonance cholangiopancreatography findings using the Cambridge classification as the reference standard. Unenhanced T1 maps were acquired using a three-dimensional dual flip-angle gradient-echo technique on the same 1.5 T scanner with the same imaging parameters. Results: There was no significant difference between the T1 relaxation times of Cambridge 0 and 1 group (p = 0.58). There was a significant difference (p = 0.0003) in the mean T1 relaxation times of the pancreas between the combined Cambridge 0 and 1 (mean = 639 msec, 95% CI: 617, 660) and Cambridge 2 groups (mean = 726 msec, 95% CI: 692, 759). There was significant difference (p = 0.0009) in the mean T1 relaxation times of the pancreas between the Cambridge 0 (mean = 636 msec, 95% CI: 606, 666) and Cambridge 2 groups (mean = 726 msec, 95% CI: 692,759) as well as between Cambridge 1 (mean = 643 msec, 95% CI: 608, 679) and Cambridge 2 groups (mean = 726 msec, 95% CI: 692,759) (p = 0.0017). Bland–Altman analysis showed measurements of one reader to be marginally higher than the other by 15.7 msec (2.4%, p = 0.04). Conclusion: T1 mapping is a practical method capable of quantitatively reflecting morphologic changes even in the early stages of chronic pancreatitis, and demonstrates promise for future implementation in routine clinical imaging protocols. Advances in knowledge: T1 mapping can distinguish subtle parenchymal changes seen in early stage CP, and demonstrates promise for implementation in routine imaging protocols for the diagnosis of CP.

scholarly journals Reproducibility of T1 relaxation times in diagnostic MRI: A phantom study

2021 ◽  
pp. 100038
Author(s):  
Derick Yongabi ◽  
Nathalie Mertens ◽  
Ronald Peeters
Keyword(s):  
Relaxation Times ◽  
Phantom Study ◽  
T1 Relaxation

scholarly journals QTC DISPERSION ON 12-LEAD ELECTROCARDIOGRAM IS INVERSELY CORRELATED WITH T1 RELAXATION TIMES IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY

2014 ◽  
Vol 63 (12) ◽  
pp. A1197
Author(s):  
David Hurtado de Mendoza ◽  
Celia P. Corona-Villalobos ◽  
Styliani Vakrou ◽  
Stefan L. Zimmerman ◽  
Yalda Soleimanifard ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Relaxation Times ◽  
Qtc Dispersion ◽  
T1 Relaxation

Magnetic resonance relaxometry in monozygotic twins discordant and concordant for schizophrenia

2005 ◽  
Vol 20 (1) ◽  
pp. 41-44 ◽  
Author(s):  
Filip Spaniel ◽  
Vit Herynek ◽  
Tomas Hajek ◽  
Monika Dezortova ◽  
Jiri Horacek ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Globus Pallidus ◽  
Relaxation Times ◽  
Monozygotic Twins ◽  
T2 Relaxation ◽  
T1 Relaxation ◽  
Significant Prolongation ◽  
Healthy Control ◽  
Genetic Loading ◽  
Mz Twins

AbstractT1 and T2 relaxation times were examined in four pairs of monozygotic (MZ) twins discordant and concordant for schizophrenia with low and high genetic loading for the illness and five healthy control MZ twin pairs. Patients with schizophrenia (n = 11) showed significant prolongation in T1 relaxation times in the globus pallidus (GP) bilaterally (P < 0.005, Bonferroni corrected) when compared to 14 healthy MZ twins.

Magnetic resonance imaging T1 relaxation times for the liver, pancreas and spleen in healthy children at 1.5 and 3 tesla

2019 ◽  
Vol 49 (8) ◽  
pp. 1018-1024 ◽  
Author(s):  
Leah A. Gilligan ◽  
Jonathan R. Dillman ◽  
Jean A. Tkach ◽  
Stavra A. Xanthakos ◽  
Jacqueline K. Gill ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Relaxation Times ◽  
3 Tesla ◽  
Healthy Children ◽  
Resonance Imaging ◽  
T1 Relaxation

scholarly journals Quantitative T1 mapping of the normal brain from early infancy to adulthood

2020 ◽  
Author(s):  
Daniel Gräfe ◽  
Jens Frahm ◽  
Andreas Merkenschlager ◽  
Dirk Voit ◽  
Franz Wolfgang Hirsch
Keyword(s):  
White Matter ◽  
Spatial Resolution ◽  
Gray Matter ◽  
T1 Mapping ◽  
Relaxation Times ◽  
Early Infancy ◽  
Normal Brain ◽  
Regression Equations ◽  
T1 Relaxation ◽  
Pediatric Brain

Abstract Background Quantitative mapping of MRI relaxation times is expected to uncover pathological processes in the brain more subtly than standard MRI techniques with weighted contrasts. So far, however, most mapping techniques suffer from a long measuring time, low spatial resolution or even sensitivity to magnetic field inhomogeneity. Objective To obtain T1 relaxation times of the normal brain from early infancy to adulthood using a novel technique for fast and accurate T1 mapping at high spatial resolution. Materials and methods We performed whole-brain T1 mapping within less than 3 min in 100 patients between 2 months and 18 years of age with normal brain at a field strength of 3 T. We analyzed T1 relaxation times in several gray-matter nuclei and white matter. Subsequently, we derived regression equations for mean value and confidence interval. Results T1 relaxation times of the pediatric brain rapidly decrease in all regions within the first 3 years of age, followed by a significantly weaker decrease until adulthood. These characteristics are more pronounced in white matter than in deep gray matter. Conclusion Regardless of age, quantitative T1 mapping of the pediatric brain is feasible in clinical practice. Normal age-dependent values should contribute to improved discrimination of subtle intracerebral alterations.

scholarly journals Validation and feasibility of liver T1 mapping using free breathing MOLLI sequence in children and young adults

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yeon Jin Cho ◽  
Woo Sun Kim ◽  
Young Hun Choi ◽  
Seul Bi Lee ◽  
SeungHyun Lee ◽  
...  
Keyword(s):  
Young Adults ◽  
Relaxation Times ◽  
Free Breathing ◽  
Phantom Study ◽  
Inversion Recovery ◽  
Breath Hold ◽  
T1 Relaxation ◽  
Molli Sequence ◽  
Children And Young Adults ◽  
The Mean

Abstract We investigated the feasibility of free-breathing modified Look-Locker inversion recovery (MOLLI) sequence for measuring hepatic T1 values in children and young adults. To investigate the accuracy and the reproducibility of the T1 maps, a phantom study was performed with 12 different gadoterate meglumine concentrations and the T1 relaxation times of phantoms measured with the MOLLI sequence were compared against those measured with three different sequences: spin-echo inversion recovery, variable flip angle (VFA), and VFA with B1 correction. To evaluate the feasibility of free-breathing MOLLI sequence, hepatic T1 relaxation times obtained by free-breathing and breath-hold technique in twenty patients were compared. The phantom study revealed the excellent accuracy and reproducibility of MOLLI. In twenty patients, the mean value of hepatic T1 values obtained by free-breathing (606.7 ± 64.5 ms) and breath-hold (609.8 ± 64.0 ms) techniques showed no significant difference (p > 0.05). The Bland–Altman plot between the free-breathing and breath-hold revealed that the mean difference of T1 values was − 3.0 ms (− 0.5%). Therefore, T1 relaxation times obtained by MOLLI were comparable to the values obtained using the standard inversion recovery method. The hepatic T1 relaxation times measured by MOLLI technique with free-breathing were comparable to those obtained with breath-hold in children and young adults.

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