A phase I study of olaratumab, an anti-platelet-derived growth factor receptor alpha (PDGFRα) monoclonal antibody, in patients with advanced solid tumors

E. Gabriela Chiorean; Christopher Sweeney; Hagop Youssoufian; Amy Qin; Aruna Dontabhaktuni; Nick Loizos; Johannes Nippgen; Robert Amato

doi:10.1007/s00280-014-2389-9

A phase I study of olaratumab, an anti-platelet-derived growth factor receptor alpha (PDGFRα) monoclonal antibody, in patients with advanced solid tumors

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-014-2389-9 ◽

2014 ◽

Vol 73 (3) ◽

pp. 595-604 ◽

Cited By ~ 42

Author(s):

E. Gabriela Chiorean ◽

Christopher Sweeney ◽

Hagop Youssoufian ◽

Amy Qin ◽

Aruna Dontabhaktuni ◽

...

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Phase I ◽

Solid Tumors ◽

Phase I Study ◽

Growth Factor Receptor ◽

Platelet Derived Growth Factor ◽

Advanced Solid Tumors ◽

Receptor Alpha ◽

Factor Receptor Alpha

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Phase I study of every 2- or 3-week dosing of ramucirumab, a human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2 in patients with advanced solid tumors

Annals of Oncology ◽

10.1093/annonc/mdv144 ◽

2015 ◽

Vol 26 (6) ◽

pp. 1230-1237 ◽

Cited By ~ 42

Author(s):

E.G. Chiorean ◽

H.I. Hurwitz ◽

R.B. Cohen ◽

J.D. Schwartz ◽

R.P. Dalal ◽

...

Keyword(s):

Monoclonal Antibody ◽

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Phase I ◽

Solid Tumors ◽

Phase I Study ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Advanced Solid Tumors ◽

Endothelial Growth Factor

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Phase I study of humanized monoclonal antibody AVE1642 directed against the type 1 insulin-like growth factor receptor (IGF-1R), administered in combination with anticancer therapies to patients with advanced solid tumors

Annals of Oncology ◽

10.1093/annonc/mds511 ◽

2013 ◽

Vol 24 (3) ◽

pp. 784-791 ◽

Cited By ~ 32

Author(s):

V.M. Macaulay ◽

M.R. Middleton ◽

A.S. Protheroe ◽

A. Tolcher ◽

V. Dieras ◽

...

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Phase I ◽

Solid Tumors ◽

Phase I Study ◽

Growth Factor Receptor ◽

Advanced Solid Tumors ◽

Insulin Like Growth Factor ◽

Humanized Monoclonal Antibody

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Abstract B123: A phase I study of R1507, a human monoclonal antibody IGF‐1R (insulin‐like growth factor receptor) antagonist in patients with advanced solid tumors

10.1158/1535-7163.targ-09-b123 ◽

2009 ◽

Author(s):

Lia Gore ◽

Joseph Aisner ◽

Razelle Kurzrock ◽

Cinara D. McCarthy ◽

Erica Winter ◽

...

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Phase I ◽

Receptor Antagonist ◽

Solid Tumors ◽

Phase I Study ◽

Human Monoclonal Antibody ◽

Growth Factor Receptor ◽

Advanced Solid Tumors ◽

Insulin Like Growth Factor

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Faculty Opinions recommendation of Phase I study of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor, in patients with advanced solid tumors.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14346.471799 ◽

2006 ◽

Author(s):

Jeffrey Evans

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Phase I ◽

Solid Tumors ◽

Phase I Study ◽

Growth Factor Receptor ◽

Advanced Solid Tumors ◽

Irreversible Inhibitor ◽

Epidermal Growth

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A Novel Pharmacodynamic Biomarker and Mechanistic Modeling Facilitate the Development of Tovetumab, a Monoclonal Antibody Directed Against Platelet-Derived Growth Factor Receptor Alpha, for Cancer Therapy

The AAPS Journal ◽

10.1208/s12248-020-00523-3 ◽

2020 ◽

Vol 23 (1) ◽

Author(s):

Meina Liang ◽

Bing Wang ◽

Amy Schneider ◽

Inna Vainshtein ◽

Lorin Roskos

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Cancer Therapy ◽

Growth Factor Receptor ◽

Mechanistic Modeling ◽

Platelet Derived Growth Factor ◽

Receptor Alpha ◽

Factor Receptor Alpha

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552 Evaluation of the pharmacokinetic (PK) interactions between cetuximab and irinotecan in patients with epidermal growth factor receptor (EGFR)-expressing advanced solid tumors. Results of a phase I study

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(03)90584-2 ◽

2003 ◽

Vol 1 (5) ◽

pp. S167 ◽

Cited By ~ 3

Author(s):

C. Delbaldo ◽

J.Y. Pierga ◽

V. Dieras ◽

S. Faivre ◽

M. Bonnay ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Phase I ◽

Solid Tumors ◽

Phase I Study ◽

Growth Factor Receptor ◽

Advanced Solid Tumors ◽

Epidermal Growth

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A phase I study evaluating cixutumumab, a type 1 insulin-like growth factor receptor inhibitor, given every 2 or 3 weeks in Japanese patients with advanced solid tumors

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-016-3041-7 ◽

2016 ◽

Vol 77 (6) ◽

pp. 1253-1262 ◽

Cited By ~ 4

Author(s):

Toshihiko Doi ◽

Kohei Shitara ◽

Takashi Kojima ◽

Takayuki Yoshino ◽

Aruna Dontabhaktuni ◽

...

Keyword(s):

Growth Factor ◽

Phase I ◽

Solid Tumors ◽

Phase I Study ◽

Growth Factor Receptor ◽

Japanese Patients ◽

Advanced Solid Tumors ◽

Insulin Like Growth Factor ◽

Receptor Inhibitor

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First‐in‐human phase I study of E7090, a novel selective fibroblast growth factor receptor inhibitor, in patients with advanced solid tumors

Cancer Science ◽

10.1111/cas.14265 ◽

2020 ◽

Vol 111 (2) ◽

pp. 571-579 ◽

Cited By ~ 1

Author(s):

Takafumi Koyama ◽

Toshio Shimizu ◽

Satoru Iwasa ◽

Yutaka Fujiwara ◽

Shunsuke Kondo ◽

...

Keyword(s):

Growth Factor ◽

Phase I ◽

Fibroblast Growth Factor ◽

Solid Tumors ◽

Phase I Study ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Advanced Solid Tumors ◽

Fibroblast Growth ◽

Receptor Inhibitor

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A Phase I Study of Weekly R1507, A Human Monoclonal Antibody Insulin-like Growth Factor-I Receptor Antagonist, in Patients with Advanced Solid Tumors

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-09-3220 ◽

2010 ◽

Vol 16 (8) ◽

pp. 2458-2465 ◽

Cited By ~ 123

Author(s):

Razelle Kurzrock ◽

Amita Patnaik ◽

Joseph Aisner ◽

Terri Warren ◽

Stephen Leong ◽

...

Keyword(s):

Monoclonal Antibody ◽

Growth Factor ◽

Phase I ◽

Receptor Antagonist ◽

Solid Tumors ◽

Phase I Study ◽

Human Monoclonal Antibody ◽

Advanced Solid Tumors ◽

Insulin Like Growth Factor ◽

Factor I

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Abstract LB-145: Results of a phase I study of AZD4547, an inhibitor of fibroblast growth factor receptor (FGFR), in patients with advanced solid tumors .

10.1158/1538-7445.am2013-lb-145 ◽

2013 ◽

Cited By ~ 23

Author(s):

Fabrice Andre ◽

Malcolm Ranson ◽

Emma Dean ◽

Andrea Varga ◽

Ruud van der Noll ◽

...

Keyword(s):

Growth Factor ◽

Phase I ◽

Fibroblast Growth Factor ◽

Solid Tumors ◽

Phase I Study ◽

Fibroblast Growth Factor Receptor ◽

Growth Factor Receptor ◽

Advanced Solid Tumors ◽

Fibroblast Growth

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