Vascular risk factors and their association to serum androgen levels in a population-based cohort of 75-year-old men over 5 years: results of the VITA study

2009 ◽  
Vol 28 (2) ◽  
pp. 209-214 ◽  
Author(s):  
Anton Ponholzer ◽  
Stephan Madersbacher ◽  
Michael Rauchenwald ◽  
Susanne Jungwirth ◽  
Peter Fischer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Population Based ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Old Men ◽  
Androgen Levels

scholarly journals Differing Pattern of Ambulatory Blood Pressure in Very Elderly Men Expresses Dynamics in Atherosclerotic Load in the Senescence

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Arkadiusz Siennicki-Lantz ◽  
Sölve Elmståhl
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Ambulatory Blood Pressure ◽  
Blood Pressure Measurement ◽  
Ankle Brachial Index ◽  
The Elderly ◽  
Population Based ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Pressure Development

To assess an impact of vascular risk factors on ambulatory blood pressure measurement (ABPM) in the elderly, we followed up a population-based cohort of men from 68 until 82 years, when 104 survivors underwent ABPM.Results. At age 68, hypertension and high clinic blood pressure (CBP) did not predict ABPM level. Smoking and low ankle-brachial index (ABI) predicted higher ABPM variability and pulse pressure (PP), but not absolute ABPM values. At age 82, hypertension, high or increasing CBP, strongly positively correlated with all variables of ABPM. Carotid stenosis, low or declining ABI during followup, correlated with higher nocturnal ABPM and PP.Concluding. Hypertension and vascular risk factors in a cohort of 68-year-old men do not result in higher ABPM at age 82, possibly due to inflection point in their pressure development. Higher ABPM reflects instead an increasing CBP and aggravating atherosclerosis during the preceding decade in that part of the cohort with previously favorable risk factor status.

Prevalence of stroke in Argentina: A door-to-door population-based study (EstEPA)

2020 ◽  
pp. 174749302093276 ◽  
Author(s):  
SF Ameriso ◽  
MM Gomez-Schneider ◽  
MA Hawkes ◽  
VA Pujol-Lereis ◽  
DE Dossi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Latin American ◽  
Neurological Status ◽  
Population Based ◽  
Vascular Risk Factors ◽  
Stroke Survivors ◽  
Vascular Risk ◽  
Population Based Study ◽  
Stroke Prevalence ◽  
Obstructive Sleep

Background Stroke burden is highest and is still rising in low- and middle-income countries. Epidemiologic stroke data are lacking in many of these countries. Stroke prevalence in Argentina has been unexplored for almost three decades. Aim This population-based study aims to determine prevalence of stroke in a representative sample of the Argentinean population. Methods We performed a door-to-door survey of randomly selected households in a city of 18,650 inhabitants. A structured questionnaire screening for potential stroke cases was used. All subjects screened positive were then evaluated by stroke neurologists for final adjudication. Data about stroke subtypes, neurological status, vascular risk factors, medications, and diagnostic tests were also collected. Results Among 2156 surveys, 294 were screened positive for a possible stroke. After neurological evaluation, there were 41 confirmed cases. The adjusted stroke prevalence was 1,974/100,000 inhabitants older than 40 years, and it was higher in men than in women (26.3‰ vs 13.2‰, p<0.01). Prevalence of ischemic stroke, intracranial hemorrhage, and transient ischemic attack were 15.8‰, 2.93‰, and 2.93‰, respectively. The most prevalent vascular risk factors in stroke survivors were hypertension, obstructive sleep apnea, and dyslipidemia. Conclusion Approximately 2 in every 100 subjects older than 40 years in this population are stroke survivors. Stroke prevalence in Argentina has remained stable over the last 30 years; it is higher than in most Latin American countries and similar to western populations.

scholarly journals Mild cognitive impairment: Incidence and vascular risk factors in a population-based cohort

Neurology ◽  
2013 ◽  
Vol 80 (23) ◽  
pp. 2112-2120 ◽  
Author(s):  
M. Ganguli ◽  
B. Fu ◽  
B. E. Snitz ◽  
T. F. Hughes ◽  
C.-C. H. Chang
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Population Based ◽  
Vascular Risk Factors ◽  
Vascular Risk

scholarly journals Brain deep medullary veins on 3-T MRI in a population-based cohort

2020 ◽  
pp. 0271678X2091846
Author(s):  
Dong-Hui Ao ◽  
Ding-Ding Zhang ◽  
Fei-Fei Zhai ◽  
Jiang-Tao Zhang ◽  
Fei Han ◽  
...  
Keyword(s):  
Risk Factors ◽  
Brain Atrophy ◽  
Small Vessel Disease ◽  
Population Based ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Neurodegenerative Process ◽  
Age Related ◽  
Deep Medullary Veins

Our aim is to investigate whether vascular risk factors are associated with cerebral deep medullary veins (DMVs) and whether DMVs are associated with MRI markers of cerebral small vessel disease (CSVD) or risk of stroke. In a community-based cohort of 1056 participants (mean age 55.7 years), DMVs were identified on susceptibility-weighted imaging (SWI) and counted in periventricular regions. Neuroimaging markers including lacunes, whiter matter hyperintensity (WMH), microbleeds, enlarged perivascular space, and brain atrophy were evaluated. The number of DMVs decreased with age (p = 0.007). After adjusting for age and sex, the number of DMVs was not associated with traditional vascular risk factors. Fewer DMVs was associated with increase of WMH and lacunes, but the association vanished after adjustment for vascular risk factors. However, fewer DMVs were independently associated with brain atrophy (p < 0.001). DMVs were not associated with three-year risk of stroke. Our results suggest that DMV is significantly different from other MRI markers of CSVD regarding risk factors, association with other CSVD markers, and risk of stroke. Nonetheless, the significant association between DMV and brain atrophy suggested the potential role of venules in age-related neurodegenerative process, which deserves further investigation.

Abstract 91: Small Perivascular Spaces as Vascular Risk Factors

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Jose Gutierrez ◽  
Chuanhui Dong ◽  
Sandino Cespedes ◽  
Tatjana Rundek ◽  
Ralph Sacco ◽  
...  
Keyword(s):  
Risk Factors ◽  
Population Based ◽  
Vascular Risk Factors ◽  
Vascular Event ◽  
Perivascular Spaces ◽  
Vascular Risk ◽  
Vascular Events ◽  
High Burden ◽  
Lacunar Infarcts ◽  
Vascular Death

Introduction: Small perivascular spaces (SPVS) are gaining momentum as imaging biomarkers of cerebrovascular health. Hypothesis: SPVS confer vascular risks and the coexistence of SPVS with lacunar infarcts (LI) heightens these risks. Methods: Stroke-free participants in the population-based Northern Manhattan Study were followed for incident stroke (ischemic and hemorrhagic), MI, all death, vascular death, and any vascular event. Lesions with diameter of 3 mm or less and absence of FLAIR rim were classified as SPVS on a semi-quantitative scale (range 0 to 28). We defined “high SPVS burden” as the upper quintile and compared the rate of vascular events in this group to individuals in the lower 4 quintiles combined. LI were defined as lesions greater than 3 mm with associated FLAIR rim, round shape, and typical location. Cox models were used to calculate risks of outcomes after adjusting for confounders. Results: This analysis includes 1208 NOMAS participants (40% male, 65% Hispanic; mean age 71 ± 9 years at time of MRI) followed a mean of 6 ± 2 years. SPVS were present in 91% of the sample (median SPVS scale score 5). Compared to participants with a lesser burden of SPVS, participants with a high SPVS burden had a higher incidence rate per 1000 person-years of death (48 vs 34), vascular death (20 vs 11), ischemic stroke (12 vs 7) and any vascular event (37 vs 24). After adjusting for demographics and vascular risk factors, participants with a high burden of SPVS had a higher risk of death (HR 1.35, 1.00-1.78), vascular death (HR 1.55, 0.96-2.51), any stroke (HR 1.53, 0.91-2.57), MI (HR 1.29, 0.69-2.41), and any vascular event (HR 1.50, 1.07-2.11). The presence of lacunar infarcts was an effect modifier such that those with LI and a high SPVS burden had a greater risk of vascular death (B=0.63, P=0.03), any stroke (B=0.72, P=0.03) and any vascular event (B=0.54, P=0.02) compared to those without LI. Conclusions: In this multi-ethnic, population-based study, participants with a high burden of SPVS had increased incidence rates of vascular events. Furthermore, the joint presence of SPVS and LI heighten the risk of vascular death, any stroke and any vascular event. The presence of SPVS may help select subjects for randomized trials to assess intervention strategies.

Vascular Risk Factors and Dementia: 40-Year Follow-Up of a Population-Based Cohort

2011 ◽  
Vol 31 (6) ◽  
pp. 460-466 ◽  
Author(s):  
Elina Rönnemaa ◽  
Björn Zethelius ◽  
Lars Lannfelt ◽  
Lena Kilander
Keyword(s):  
Risk Factors ◽  
Population Based ◽  
Vascular Risk Factors ◽  
Vascular Risk
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